{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:29:48Z","timestamp":1791271788107,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.hoc.2022.07.001","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T23:02:20Z","timestamp":1663887740000},"page":"897-910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Interplay Among Pancreatic Cancer, Cachexia, Body Composition, and Diabetes"],"prefix":"10.1016","volume":"36","author":[{"given":"Richard F.","family":"Dunne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Roeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.hoc.2022.07.001_bib1","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.hoc.2022.07.001_bib2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.hoc.2022.07.001_bib3","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11605-008-0505-z","article-title":"Cachexia worsens prognosis in patients with resectable pancreatic cancer","volume":"12","author":"Bachmann","year":"2008","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.7861\/clinmedicine.6-2-140","article-title":"Cancer cachexia and fatigue","volume":"6","author":"Stewart","year":"2006","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.hoc.2022.07.001_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijsu.2018.09.014","article-title":"Sarcopenia and sarcopenic obesity are significantly associated with poorer overall survival in patients with pancreatic cancer: systematic review and meta-analysis","volume":"59","author":"Mintziras","year":"2018","journal-title":"Int J Surg"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.clnu.2003.07.001","article-title":"Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer","volume":"23","author":"Davidson","year":"2004","journal-title":"Clin Nutr"},{"key":"10.1016\/j.hoc.2022.07.001_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1471-2407-9-255","article-title":"Pancreatic cancer related cachexia: influence on metabolism and correlation to weight loss and pulmonary function","volume":"9","author":"Bachmann","year":"2009","journal-title":"BMC Cancer"},{"issue":"12","key":"10.1016\/j.hoc.2022.07.001_bib9","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.3390\/cancers11121861","article-title":"Cachexia and sarcopenia in older adults with cancer: a comprehensive review","volume":"11","author":"Dunne","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.hoc.2022.07.001_bib10","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"10.1016\/j.hoc.2022.07.001_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nm.3686","article-title":"Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development","volume":"20","author":"Mayers","year":"2014","journal-title":"Nat Med"},{"issue":"7711","key":"10.1016\/j.hoc.2022.07.001_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-018-0235-7","article-title":"Altered exocrine function can drive adipose wasting in early pancreatic cancer","volume":"558","author":"Danai","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.hoc.2022.07.001_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2015.10.038","article-title":"The central role of hypothalamic inflammation in the acute illness response and cachexia","volume":"54","author":"Burfeind","year":"2016","journal-title":"Semin Cell Dev Biol"},{"issue":"7","key":"10.1016\/j.hoc.2022.07.001_bib14","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/glia.23796","article-title":"Microglia in the hypothalamus respond to tumor-derived factors and are protective against cachexia during pancreatic cancer","volume":"68","author":"Burfeind","year":"2020","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.hoc.2022.07.001_bib15","first-page":"1126","article-title":"Symptom profiles and palliative care in advanced pancreatic cancer: a prospective study","volume":"14","author":"Labori","year":"2006","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2022.07.001_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.bjc.6690654","article-title":"The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer","volume":"81","author":"Barber","year":"1999","journal-title":"Br J Cancer"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/sj.bjc.6601620","article-title":"Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids","volume":"90","author":"Moses","year":"2004","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2022.07.001_bib18","first-page":"219","article-title":"Symptoms in advanced pancreatic cancer are of importance for energy intake","volume":"21","author":"Bye","year":"2013","journal-title":"Support Care Cancer"},{"issue":"6","key":"10.1016\/j.hoc.2022.07.001_bib19","first-page":"1809","article-title":"A\u00a0predictive model of inflammatory markers and patient-reported symptoms for cachexia in newly diagnosed pancreatic cancer patients","volume":"25","author":"Fogelman","year":"2017","journal-title":"Support Care Cancer"},{"issue":"3","key":"10.1016\/j.hoc.2022.07.001_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/nu9030183","article-title":"Pancreatic exocrine insufficiency in pancreatic cancer","volume":"9","author":"Vujasinovic","year":"2017","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.hoc.2022.07.001_bib21","first-page":"2749","article-title":"Struggling with food and eating-life after major upper gastrointestinal surgery","volume":"21","author":"Carey","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.hoc.2022.07.001_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejon.2016.12.002","article-title":"Symptoms and self-care following pancreaticoduodenectomy: Perspectives from patients and healthcare professionals - Foundation for an interactive ICT application","volume":"26","author":"Gustavell","year":"2017","journal-title":"Eur J Oncol Nurs"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib23","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1634\/theoncologist.2018-0266","article-title":"Pancreas cancer-associated weight loss","volume":"24","author":"Hendifar","year":"2019","journal-title":"Oncologist"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1634\/theoncologist.2019-0813","article-title":"Leveraging the potential synergy between patient-reported outcomes and body composition analysis in patients with cancer","volume":"25","author":"van Seventer","year":"2020","journal-title":"Oncologist"},{"issue":"6","key":"10.1016\/j.hoc.2022.07.001_bib25","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1152\/japplphysiol.00744.2004","article-title":"Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image","volume":"97","author":"Shen","year":"2004","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"19","key":"10.1016\/j.hoc.2022.07.001_bib26","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1200\/JCO.21.00102","article-title":"Sarcopenia in the older adult with cancer","volume":"39","author":"Williams","year":"2021","journal-title":"J\u00a0Clin Oncol"},{"issue":"14","key":"10.1016\/j.hoc.2022.07.001_bib27","first-page":"3033","article-title":"The prognostic value of low muscle mass in pancreatic cancer patients: a systematic review and meta-analysis","volume":"10","author":"Pierobon","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib28","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/bjs.10063","article-title":"Effect of sarcopenia and visceral obesity on mortality and pancreatic fistula following pancreatic cancer surgery","volume":"103","author":"Pecorelli","year":"2016","journal-title":"Br J Surg"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1017\/S0007114512001067","article-title":"Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: the relationship with diabetes and anaemia","volume":"109","author":"Di Sebastiano","year":"2013","journal-title":"Br J Nutr"},{"issue":"11\u201312","key":"10.1016\/j.hoc.2022.07.001_bib30","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.nut.2016.04.002","article-title":"A\u00a0high visceral adipose tissue-to-skeletal muscle ratio as a determinant of major complications after pancreatoduodenectomy for cancer","volume":"32","author":"Sandini","year":"2016","journal-title":"Nutrition"},{"issue":"12","key":"10.1016\/j.hoc.2022.07.001_bib31","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.hpb.2020.04.004","article-title":"The effects of sarcopenia and sarcopenic obesity after pancreaticoduodenectomy in patients with pancreatic head cancer","volume":"22","author":"Ryu","year":"2020","journal-title":"HPB (Oxford)"},{"issue":"10","key":"10.1016\/j.hoc.2022.07.001_bib32","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.hoc.2022.07.001_bib33","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.pan.2020.07.411","article-title":"Prehabilitation prior to surgery for pancreatic cancer: a systematic review","volume":"20","author":"Bundred","year":"2020","journal-title":"Pancreatology"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clnu.2015.08.005","article-title":"The impact of sarcopenia and myosteatosis on outcomes of unresectable pancreatic cancer or distal cholangiocarcinoma","volume":"35","author":"Rollins","year":"2016","journal-title":"Clin Nutr"},{"issue":"10","key":"10.1016\/j.hoc.2022.07.001_bib35","doi-asserted-by":"crossref","first-page":"e0139749","DOI":"10.1371\/journal.pone.0139749","article-title":"Skeletal muscle depletion predicts the prognosis of patients with advanced pancreatic cancer undergoing palliative chemotherapy, independent of body mass index","volume":"10","author":"Choi","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pan.2021.12.013","article-title":"Impact of sarcopenia on prediction of progression-free survival and overall survival of patients with pancreatic ductal adenocarcinoma receiving first-line gemcitabine and nab-paclitaxel chemotherapy","volume":"22","author":"Emori","year":"2022","journal-title":"Pancreatology"},{"issue":"9","key":"10.1016\/j.hoc.2022.07.001_bib37","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1089\/ars.2011.3965","article-title":"Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress","volume":"15","author":"Gilliam","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"12","key":"10.1016\/j.hoc.2022.07.001_bib38","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1158\/1055-9965.EPI-19-0370","article-title":"Postdiagnosis loss of skeletal muscle, but not adipose tissue, is associated with shorter survival of patients with advanced pancreatic cancer","volume":"28","author":"Babic","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"22","key":"10.1016\/j.hoc.2022.07.001_bib39","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1158\/1078-0432.CCR-09-1525","article-title":"Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer","volume":"15","author":"Tan","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"8","key":"10.1016\/j.hoc.2022.07.001_bib40","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","article-title":"Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment","volume":"15","author":"Prado","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.hoc.2022.07.001_bib41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pan.2018.11.001","article-title":"Sarcopenia is a reliable prognostic factor in patients with advanced pancreatic cancer receiving FOLFIRINOX chemotherapy","volume":"19","author":"Kurita","year":"2019","journal-title":"Pancreatology"},{"issue":"7","key":"10.1016\/j.hoc.2022.07.001_bib42","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jcsm.12660","article-title":"Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia","volume":"12","author":"Dodds","year":"2021","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib44","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3945\/ajcn.113.058123","article-title":"Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort","volume":"98","author":"Stolzenberg-Solomon","year":"2013","journal-title":"Am J Clin Nutr"},{"issue":"20","key":"10.1016\/j.hoc.2022.07.001_bib45","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1001\/jama.1995.03520440059037","article-title":"Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis","volume":"273","author":"Everhart","year":"1995","journal-title":"JAMA"},{"issue":"22","key":"10.1016\/j.hoc.2022.07.001_bib46","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1001\/jama.294.22.2872","article-title":"Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers","volume":"294","author":"Stolzenberg-Solomon","year":"2005","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.hoc.2022.07.001_bib47","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrendo.2014.94","article-title":"Obesity and cancer--mechanisms underlying tumour progression and recurrence","volume":"10","author":"Park","year":"2014","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/MPA.0000000000001037","article-title":"The interface of pancreatic cancer with diabetes, obesity, and inflammation: research gaps and opportunities: summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop","volume":"47","author":"Abbruzzese","year":"2018","journal-title":"Pancreas"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib50","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.gastro.2005.05.007","article-title":"Probability of pancreatic cancer following diabetes: a population-based study","volume":"129","author":"Chari","year":"2005","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib51","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1053\/j.gastro.2008.01.039","article-title":"Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus","volume":"134","author":"Pannala","year":"2008","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.hoc.2022.07.001_bib52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/j.gastro.2007.10.040","article-title":"Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer","volume":"134","author":"Chari","year":"2008","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.hoc.2022.07.001_bib53","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1053\/j.gastro.2018.05.023","article-title":"Model to determine risk of pancreatic cancer in patients with new-onset diabetes","volume":"155","author":"Sharma","year":"2018","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib54","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jcsm.12553","article-title":"Relationship between pancreatic cancer-associated diabetes and cachexia","volume":"11","author":"Liao","year":"2020","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib55","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/jcsm.12910","article-title":"Addressing unmet needs for people with cancer cachexia: recommendations from a multistakeholder workshop","volume":"13","author":"Garcia","year":"2022","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.hoc.2022.07.001_bib56","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1200\/JCO.2015.63.0830","article-title":"Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial","volume":"34","author":"Basch","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"10.1016\/j.hoc.2022.07.001_bib57","first-page":"570","article-title":"The functional assessment of cancer therapy scale: development and validation of the general measure","volume":"11","author":"Cella","year":"1993"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib58","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s11136-012-0217-4","article-title":"Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer","volume":"22","author":"Cella","year":"2013","journal-title":"Qual Life Res"},{"issue":"9","key":"10.1016\/j.hoc.2022.07.001_bib59","first-page":"3883","article-title":"Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) is a valid screening tool in chemotherapy outpatients","volume":"24","author":"Abbott","year":"2016","journal-title":"Support Care Cancer"},{"issue":"9","key":"10.1016\/j.hoc.2022.07.001_bib60","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s12603-009-0214-7","article-title":"Validation of the Mini Nutritional Assessment Short-Form (MNA\u00ae-SF): a practical tool for identification of nutritional status","volume":"13","author":"Kaiser","year":"2009","journal-title":"J\u00a0Nutr Health Aging"},{"issue":"1","key":"10.1016\/j.hoc.2022.07.001_bib61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1200\/JCO.2016.70.1474","article-title":"Integration of palliative care into standard oncology care: American Society of Clinical Oncology Clinical Practice Guideline Update","volume":"35","author":"Ferrell","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"issue":"21","key":"10.1016\/j.hoc.2022.07.001_bib62","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of cancer cachexia: ASCO Guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"issue":"33","key":"10.1016\/j.hoc.2022.07.001_bib63","doi-asserted-by":"crossref","first-page":"8500","DOI":"10.1200\/JCO.2005.01.8010","article-title":"Systematic review of the treatment of cancer-associated anorexia and weight loss","volume":"23","author":"Yavuzsen","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib64","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1200\/JCO.1993.11.4.762","article-title":"Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and\/or cachexia","volume":"11","author":"Loprinzi","year":"1993","journal-title":"J\u00a0Clin Oncol"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib65","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1200\/JCO.2002.20.2.567","article-title":"Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study","volume":"20","author":"Jatoi","year":"2002","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"10.1016\/j.hoc.2022.07.001_bib66","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/jcsm.12292","article-title":"Megestrol acetate for cachexia-anorexia syndrome. A systematic review","volume":"9","author":"Ruiz-Garc\u00eda","year":"2018","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib68","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1470-2045(15)00558-6","article-title":"Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials","volume":"17","author":"Temel","year":"2016","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.hoc.2022.07.001_bib69","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cncr.31128","article-title":"Anamorelin (ONO-7643) for the treatment of patients with non-small cell lung cancer and cachexia: Results from a randomized, double-blind, placebo-controlled, multicenter study of Japanese patients (ONO-7643-04)","volume":"124","author":"Katakami","year":"2018","journal-title":"Cancer"},{"issue":"23","key":"10.1016\/j.hoc.2022.07.001_bib70","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1002\/cncr.32406","article-title":"A\u00a0multicenter, open-label, single-arm study of anamorelin (ONO-7643) in advanced gastrointestinal cancer patients with cancer cachexia","volume":"125","author":"Hamauchi","year":"2019","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.hoc.2022.07.001_bib71","first-page":"791","article-title":"Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the US","volume":"16","author":"Henry","year":"2008","journal-title":"Support Care Cancer"},{"issue":"25","key":"10.1016\/j.hoc.2022.07.001_bib72","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1200\/JCO.2012.44.4661","article-title":"Reduction of cancer-related fatigue with dexamethasone: a double-blind, randomized, placebo-controlled trial in patients with advanced cancer","volume":"31","author":"Yennurajalingam","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"7","key":"10.1016\/j.hoc.2022.07.001_bib73","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaoncol.2016.6914","article-title":"Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis","volume":"3","author":"Mustian","year":"2017","journal-title":"JAMA Oncol"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib74","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/jcsm.12201","article-title":"A\u00a0randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer","volume":"8","author":"Solheim","year":"2017","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.hoc.2022.07.001_bib75","doi-asserted-by":"crossref","first-page":"144","DOI":"10.6004\/jnccn.2020.7615","article-title":"Cachexia and dietetic interventions in patients with esophagogastric cancer: a multicenter cohort study","volume":"19","author":"Dijksterhuis","year":"2021","journal-title":"J\u00a0Natl Compr Canc Netw"},{"issue":"8","key":"10.1016\/j.hoc.2022.07.001_bib76","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.annonc.2021.05.793","article-title":"Nutritional support during the hospital stay reduces mortality in patients with different types of cancers: secondary analysis of a prospective randomized trial","volume":"32","author":"Bargetzi","year":"2021","journal-title":"Ann Oncol"},{"issue":"5","key":"10.1016\/j.hoc.2022.07.001_bib77","first-page":"2351","article-title":"Late referral of cancer patients with malnutrition to dietitians: a prospective study of clinical practice","volume":"28","author":"Lorton","year":"2020","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.hoc.2022.07.001_bib78","first-page":"7462940","article-title":"Inadequate nutrition coverage in outpatient cancer centers: results of a national survey","volume":"2019","author":"Trujillo","year":"2019","journal-title":"J\u00a0Oncol"},{"issue":"12","key":"10.1016\/j.hoc.2022.07.001_bib79","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.jand.2021.01.009","article-title":"Telehealth during the COVID-19 pandemic: a cross-sectional survey of registered dietitian nutritionists","volume":"121","author":"Rozga","year":"2021","journal-title":"J\u00a0Acad Nutr Diet"},{"issue":"6","key":"10.1016\/j.hoc.2022.07.001_bib80","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jcf.2009.08.008","article-title":"Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis","volume":"8","author":"Trapnell","year":"2009","journal-title":"J\u00a0Cyst Fibros"},{"issue":"22","key":"10.1016\/j.hoc.2022.07.001_bib81","first-page":"22564","article-title":"Upregulated GDF-15 expression facilitates pancreatic ductal adenocarcinoma progression through orphan receptor GFRAL","volume":"12","author":"Zhao","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"34","key":"10.1016\/j.hoc.2022.07.001_bib82","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1200\/JCO.2015.61.4578","article-title":"Randomized, double-blind, phase II study of ruxolitinib or placebo in combination with capecitabine in patients with metastatic pancreatic cancer for whom therapy with gemcitabine has failed","volume":"33","author":"Hurwitz","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib83","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/jcsm.12136","article-title":"ACT-ONE - ACTION at last on cancer cachexia by adapting a novel action beta-blocker","volume":"7","author":"Lainscak","year":"2016","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.hoc.2022.07.001_bib84","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/s41467-021-22361-3","article-title":"Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia","volume":"12","author":"Olson","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.hoc.2022.07.001_bib85","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/bmjspcare-2017-001440","article-title":"Cancer cachexia: rationale for the MENAC (Multimodal\u2014Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial","volume":"8","author":"Solheim","year":"2018","journal-title":"BMJ Support Palliat Care"},{"issue":"4","key":"10.1016\/j.hoc.2022.07.001_bib86","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/SPC.0000000000000301","article-title":"Research priorities in cancer cachexia: the university of Rochester Cancer Center NCI Community Oncology Research Program (NCORP) research base symposium on cancer cachexia and sarcopenia","volume":"11","author":"Dunne","year":"2017","journal-title":"Curr Opin Support Palliat Care"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858822000697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858822000697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:18:50Z","timestamp":1760185130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858822000697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0889858822000697"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2022.07.001","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Interplay Among Pancreatic Cancer, Cachexia, Body Composition, and Diabetes","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2022.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}