{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:35:30Z","timestamp":1777023330908,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology\/Oncology Clinics of North America"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.hoc.2025.07.002","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:14:51Z","timestamp":1762928091000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatic Artery Infusion Pump Therapy in Unresectable and Resectable Liver Tumors"],"prefix":"10.1016","volume":"40","author":[{"given":"Lauren M.","family":"Janczewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan P.","family":"Merkow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0002-9610(74)90161-5","article-title":"Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon","volume":"127","author":"Cady","year":"1974","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib2","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.3747\/co.21.1592","article-title":"Hepatic arterial infusion pump chemotherapy for colorectal liver metastases: an old technology in a new era","volume":"21","author":"Ko","year":"2014","journal-title":"Curr Oncol"},{"issue":"12","key":"10.1016\/j.hoc.2025.07.002_bib3","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1245\/s10434-023-14207-7","article-title":"Current practices in hepatic artery infusion (HAI) chemotherapy: an international survey of the HAI consortium research network","volume":"30","author":"Judge","year":"2023","journal-title":"Ann Surg Oncol"},{"issue":"13","key":"10.1016\/j.hoc.2025.07.002_bib4","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1245\/s10434-020-08972-y","article-title":"Implementation of a hepatic artery infusion program: initial patient selection and perioperative outcomes of concurrent hepatic artery infusion and systemic chemotherapy for colorectal liver metastases","volume":"27","author":"Creasy","year":"2020","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"10.1016\/j.hoc.2025.07.002_bib5","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.hpb.2023.12.006","article-title":"Safety and feasibility of establishing an adjuvant hepatic artery infusion program","volume":"26","author":"Janczewski","year":"2024","journal-title":"HPB (Oxford)"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.surg.2023.03.026","article-title":"Starting a successful hepatic artery infusion pump program: a practical guide","volume":"174","author":"McDonald","year":"2023","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/annonc\/mdv548","article-title":"Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV","volume":"27","author":"Levi","year":"2016","journal-title":"Ann Oncol"},{"issue":"8","key":"10.1016\/j.hoc.2025.07.002_bib8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/jso.23204","article-title":"Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease","volume":"106","author":"Ammori","year":"2012","journal-title":"J Surg Oncol"},{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/SLA.0000000000000614","article-title":"Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes","volume":"261","author":"D\u2019Angelica","year":"2015","journal-title":"Ann Surg"},{"issue":"8","key":"10.1016\/j.hoc.2025.07.002_bib10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1001\/jamasurg.2019.1694","article-title":"Role of hepatic artery infusion chemotherapy in treatment of initially unresectable colorectal liver metastases: a review","volume":"154","author":"Datta","year":"2019","journal-title":"JAMA Surg"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1245\/s10434-016-5418-6","article-title":"Hepatic arterial infusion in combination with modern systemic chemotherapy is associated with improved survival compared with modern systemic chemotherapy alone in patients with isolated unresectable colorectal liver metastases: a case-control study","volume":"24","author":"Dhir","year":"2017","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"10.1016\/j.hoc.2025.07.002_bib12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1200\/JCO.2009.24.6728","article-title":"Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)\/National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945\/CI-66","volume":"28","author":"Alberts","year":"2010","journal-title":"J Clin Oncol"},{"issue":"13","key":"10.1016\/j.hoc.2025.07.002_bib13","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1245\/s10434-019-07973-w","article-title":"Adjuvant hepatic arterial infusion pump chemotherapy after resection of colorectal liver metastases: results of a safety and feasibility study in The Netherlands","volume":"26","author":"Buisman","year":"2019","journal-title":"Ann Surg Oncol"},{"issue":"17","key":"10.1016\/j.hoc.2025.07.002_bib14","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1200\/JCO.2016.71.8346","article-title":"Perioperative hepatic arterial infusion pump chemotherapy is associated with longer survival after resection of colorectal liver metastases: a propensity score analysis","volume":"35","author":"Groot Koerkamp","year":"2017","journal-title":"J Clin Oncol"},{"issue":"27","key":"10.1016\/j.hoc.2025.07.002_bib15","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1056\/NEJM199912303412702","article-title":"Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer","volume":"341","author":"Kemeny","year":"1999","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.hoc.2025.07.002_bib16","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1200\/JCO.2005.03.8166","article-title":"Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481)","volume":"24","author":"Kemeny","year":"2006","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.hoc.2025.07.002_bib17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1001\/archsurg.1984.01390200054013","article-title":"Long-term hepatic arterial infusion chemotherapy. Anatomic considerations, operative technique, and treatment morbidity","volume":"119","author":"Daly","year":"1984","journal-title":"Arch Surg"},{"issue":"5","key":"10.1016\/j.hoc.2025.07.002_bib18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1245\/s10434-011-2102-8","article-title":"Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors","volume":"19","author":"Ito","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00000658-198508000-00007","article-title":"Sclerosing cholangitis after continuous hepatic artery infusion of FUDR","volume":"202","author":"Kemeny","year":"1985","journal-title":"Ann Surg"},{"issue":"12","key":"10.1016\/j.hoc.2025.07.002_bib20","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/j.hpb.2022.08.008","article-title":"Considerations and barriers to starting a new HAI pump program: an international survey of the HAI Consortium Research Network","volume":"24","author":"Cavnar","year":"2022","journal-title":"HPB (Oxford)"},{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1245\/s10434-023-14515-y","article-title":"Hepatic artery infusion chemotherapy: a quality framework","volume":"31","author":"Janczewski","year":"2024","journal-title":"Ann Surg Oncol"},{"issue":"10","key":"10.1016\/j.hoc.2025.07.002_bib23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.5306\/wjco.v11.i10.761","article-title":"Colorectal liver metastases: current management and future perspectives","volume":"11","author":"Martin","year":"2020","journal-title":"World J Clin Oncol"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib24","first-page":"17","article-title":"Cancer statistics","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"10.1016\/j.hoc.2025.07.002_bib25","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/annonc\/mdp029","article-title":"Regional chemotherapy for unresectable primary liver cancer: results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival","volume":"20","author":"Jarnagin","year":"2009","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.hoc.2025.07.002_bib26","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s11605-021-05195-8","article-title":"Combined primary resection with hepatic artery infusion pump implantation is safe for unresectable colorectal liver metastases","volume":"26","author":"Turley","year":"2022","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jso.26270","article-title":"Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: a multicenter, retrospective cohort study","volume":"123","author":"Muaddi","year":"2021","journal-title":"J Surg Oncol"},{"issue":"22","key":"10.1016\/j.hoc.2025.07.002_bib28","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1200\/JCO.2005.07.100","article-title":"Phase I trial of systemic oxaliplatin combination chemotherapy with hepatic arterial infusion in patients with unresectable liver metastases from colorectal cancer","volume":"23","author":"Kemeny","year":"2005","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.hoc.2025.07.002_bib29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00000658-199812000-00006","article-title":"Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. German Cooperative on Liver Metastases (Arbeitsgruppe Lebermetastasen)","volume":"228","author":"Lorenz","year":"1998","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.hoc.2025.07.002_bib30","first-page":"1499","article-title":"Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy--an intergroup study","volume":"20","author":"Kemeny","year":"2002","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.hoc.2025.07.002_bib31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/SLA.0000000000005434","article-title":"Hepatic artery infusion pumps: a surgical toolkit for intraoperative decision-making and management of hepatic artery infusion-specific complications","volume":"276","author":"Sharib","year":"2022","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1470-2045(09)70330-4","article-title":"Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial","volume":"11","author":"Folprecht","year":"2010","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.hoc.2025.07.002_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/jso.26911","article-title":"Hepatic arterial infusion pump chemotherapy combined with systemic therapy for patients with advanced colorectal liver metastases: outcomes in a newly established program","volume":"126","author":"Walker","year":"2022","journal-title":"J Surg Oncol"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib34","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.3747\/co.21.1577","article-title":"Hepatic arterial infusion pump chemotherapy in the management of colorectal liver metastases: expert consensus statement","volume":"21","author":"Karanicolas","year":"2014","journal-title":"Curr Oncol"},{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/1097-0142(197908)44:2<414::AID-CNCR2820440207>3.0.CO;2-3","article-title":"Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary","volume":"44","author":"Oberfield","year":"1979","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.hoc.2025.07.002_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/1097-0142(19810115)47:2<402::AID-CNCR2820470231>3.0.CO;2-B","article-title":"The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol","volume":"47","author":"Reed","year":"1981","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.hoc.2025.07.002_bib37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jamcollsurg.2005.03.019","article-title":"Technical complications and durability of hepatic artery infusion pumps for unresectable colorectal liver metastases: an institutional experience of 544 consecutive cases","volume":"201","author":"Allen","year":"2005","journal-title":"J Am Coll Surg"},{"issue":"5","key":"10.1016\/j.hoc.2025.07.002_bib38","first-page":"928","article-title":"Technical considerations and complications associated with the placement of 180 implantable hepatic arterial infusion devices","volume":"114","author":"Curley","year":"1993","journal-title":"Surgery"},{"issue":"13","key":"10.1016\/j.hoc.2025.07.002_bib39","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1245\/s10434-020-08938-0","article-title":"Short-term risk of performing concurrent procedures with hepatic artery infusion pump placement","volume":"27","author":"Brajcich","year":"2020","journal-title":"Ann Surg Oncol"}],"container-title":["Hematology\/Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858825000899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889858825000899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:15:17Z","timestamp":1762928117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889858825000899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0889858825000899"],"URL":"https:\/\/doi.org\/10.1016\/j.hoc.2025.07.002","relation":{},"ISSN":["0889-8588"],"issn-type":[{"value":"0889-8588","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic Artery Infusion Pump Therapy in Unresectable and Resectable Liver Tumors","name":"articletitle","label":"Article Title"},{"value":"Hematology\/Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hoc.2025.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}