{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:44:10Z","timestamp":1782488650488,"version":"3.54.5"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["homeopathyjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Introduction: The decision to treat subclinical hypothyroidism (SCH) with or without autoimmune thyroiditis (AIT) in children, presents a clinical dilemma. This study was undertaken to evaluate the efficacy of individualized homeopathy in these cases.<\/jats:p><jats:p>Methods: The study is an exploratory, randomized, placebo controlled, single blind trial. Out of 5059 school children (06\u201318 years) screened for thyroid disorders, 537 children had SCH\/AIT and 194 consented to participate. Based on primary outcome measures (TSH and\/or antiTPOab) three major groups were formed: Group A \u2013 SCH + AIT (n = 38; high TSH with antiTPOab+), Group B \u2013 AIT (n = 47; normal TSH with antiTPOab+) and Group C \u2013 SCH (n = 109; only high TSH) and were further randomized to two subgroups-verum and control. Individualized homeopathy or identical placebo was given to respective subgroup. 162 patients completed 18 months of study.<\/jats:p><jats:p>Results: Baseline characteristics were similar in all the subgroups. The post treatment serum TSH (Group A and C) returned to normal limits in 85.94% of verum and 64.29% of controls (p &lt; 0.006), while serum AntiTPOab titers (Group A and B) returned within normal limits in 70.27%of verum and 27.02%controls (p &lt; 0.05). Eight children (10.5%) progressed to overt hypothyroidism (OH) from control group.<\/jats:p><jats:p>Conclusion: A statistically significant decline in serum TSH values and antiTPOab titers indicates that the homeopathic intervention has not only the potential to treat SCH with or without antiTPOab but may also prevent progression to OH.<\/jats:p>","DOI":"10.1016\/j.homp.2014.08.004","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T17:31:55Z","timestamp":1411839115000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of homeopathic intervention in subclinical hypothyroidism with or without autoimmune thyroiditis in children: an exploratory randomized control study"],"prefix":"10.1055","volume":"103","author":[{"given":"Vijay K.","family":"Chauhan","sequence":"first","affiliation":[{"name":"Dr. B. R. 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