{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:05:03Z","timestamp":1789038303113,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T00:00:00Z","timestamp":1512172800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.hpb.2016.09.005","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T21:56:49Z","timestamp":1476914209000},"page":"991-999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid"],"prefix":"10.1016","volume":"18","author":[{"given":"Paul J.","family":"Karanicolas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Tarshis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin H.L.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie G.","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barto","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Pawliszyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"McCluskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2016.09.005_bib1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/00000658-200012000-00005","article-title":"Hepatic resection for colorectal liver metastases: a cost-effectiveness analysis","volume":"232","author":"Beard","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/bjs.1800740931","article-title":"Role of surgery in the treatment of primary carcinoma of the liver: a 31-year experience","volume":"74","author":"Lin","year":"1987","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib3","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/00000658-199712000-00007","article-title":"Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study","volume":"226","author":"Man","year":"1997","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib4","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/01.sla.0000141195.66155.0c","article-title":"Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database","volume":"240","author":"Poon","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib5","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/jlts.2003.50204","article-title":"Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them","volume":"9","author":"Ramos","year":"2003","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hpb.2016.09.005_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cld.2008.09.012","article-title":"Bleeding in liver surgery: prevention and treatment","volume":"13","author":"Alkozai","year":"2009","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.hpb.2016.09.005_bib7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/SLA.0b013e318184db08","article-title":"A\u00a0prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection","volume":"248","author":"Jarnagin","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib8","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.SLA.0000072371.95588.DA","article-title":"Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases","volume":"237","author":"Kooby","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1477-2574.2011.00326.x","article-title":"Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the standard criterion","volume":"13","author":"Mayo","year":"2011","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2016.09.005_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/SLA.0b013e31825b35d5","article-title":"Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis","volume":"256","author":"Acheson","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib11","first-page":"CD005033","article-title":"Perioperative blood transfusions for the recurrence of colorectal cancer","author":"Amato","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.hpb.2016.09.005_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/136518202753598672","article-title":"Minimising blood loss and transfusion requirements in hepatic resection","volume":"4","author":"Bui","year":"2002","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2016.09.005_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/bjs.1800820833","article-title":"Liver resection without blood transfusion","volume":"82","author":"Gozzetti","year":"1995","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib14","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1200\/JCO.1994.12.9.1859","article-title":"Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery","volume":"12","author":"Heiss","year":"1994","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.hpb.2016.09.005_bib15","first-page":"32","article-title":"Major liver resection without a blood transfusion: is it a realistic objective?","volume":"112","author":"Jamieson","year":"1992","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2016.09.005_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/SLA.0b013e31819ed22f","article-title":"Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma","volume":"249","author":"Katz","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1245\/s10434-010-1476-3","article-title":"Effects of perioperative red blood cell transfusion on disease recurrence and survival after pancreaticoduodenectomy for ductal adenocarcinoma","volume":"18","author":"Kneuertz","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2016.09.005_bib18","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.ejso.2009.04.008","article-title":"Predictors and prognostic significance of operative complications in patients with hepatocellular carcinoma who underwent hepatic resection","volume":"35","author":"Kusano","year":"2009","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.hpb.2016.09.005_bib19","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/bjs.1800831110","article-title":"One hundred and fifty hepatic resections: evolution of technique towards bloodless surgery","volume":"83","author":"Rees","year":"1996","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0002-9610(89)90637-5","article-title":"Liver resection without blood transfusion","volume":"157","author":"Ryan","year":"1989","journal-title":"Am J Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib21","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1046\/j.1537-2995.1995.35996029162.x","article-title":"Perioperative blood transfusion and cancer recurrence: meta-analysis for explanation","volume":"35","author":"Vamvakas","year":"1995","journal-title":"Transfusion"},{"key":"10.1016\/j.hpb.2016.09.005_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/SLA.0b013e3180603039","article-title":"Hepatic resection for colorectal metastases: value for risk scoring systems?","volume":"246","author":"Zakaria","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib23","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000103655","article-title":"Hemostatic alterations in liver disease: a review on pathophysiology, clinical consequences, and treatment","volume":"24","author":"Lisman","year":"2007","journal-title":"Dig Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0016-5085(89)90090-5","article-title":"Hemostasis in liver transplantation","volume":"97","author":"Porte","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hpb.2016.09.005_bib25","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1056\/NEJMoa0802395","article-title":"BART Investigators. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery","volume":"358","author":"Fergusson","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.hpb.2016.09.005_bib26","first-page":"CD001886","article-title":"Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion","author":"Henry","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.hpb.2016.09.005_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"Shakur","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.hpb.2016.09.005_bib28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.thromres.2008.09.015","article-title":"Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials","volume":"123","author":"Kagoma","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.hpb.2016.09.005_bib29","first-page":"A12","article-title":"Blood conservation in elective spine surgery","volume":"49","author":"Karkouti","year":"2002","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.hpb.2016.09.005_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1213\/ANE.0b013e3182264a11","article-title":"Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study","volume":"115","author":"Wang","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.hpb.2016.09.005_bib31","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1213\/ane.0b013e3181831e44","article-title":"Tranexamic acid reduces perioperative blood loss in adult patients having spinal fusion surgery","volume":"107","author":"Wong","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.hpb.2016.09.005_bib32","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/jso.23748","article-title":"Consensus and controversy in hepatic surgery: a survey of Canadian surgeons","volume":"110","author":"Truong","year":"2014","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.hpb.2016.09.005_bib33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/01.sla.0000197561.70972.73","article-title":"Perioperative parenteral tranexamic acid in liver tumor resection: a prospective randomized trial toward a \u201cblood transfusion\u201d-free hepatectomy","volume":"243","author":"Wu","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/lt.20075","article-title":"The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation: a comparative study","volume":"10","author":"Dalmau","year":"2004","journal-title":"Liver Transpl"},{"key":"10.1016\/j.hpb.2016.09.005_bib35","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1213\/ANE.0b013e3181c76d3e","article-title":"What is the preferred central venous pressure zero reference for hepatic resection?","volume":"111","author":"Giordano","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1016\/j.hpb.2016.09.005_bib36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1477-2574.2011.00433.x","article-title":"Factors in perioperative care that determine blood loss in liver surgery","volume":"14","author":"McNally","year":"2012","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2016.09.005_bib37","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/SLA.0b013e318214bee5","article-title":"Infrahepatic inferior vena cava clamping for reduction of central venous pressure and blood loss during hepatic resection: a randomized controlled trial","volume":"253","author":"Rahbari","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2016.09.005_bib38","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1213\/ane.0b013e318168b367","article-title":"Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices","volume":"106","author":"Ganter","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.hpb.2016.09.005_bib39","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1016\/j.jchromb.2011.08.003","article-title":"Determination of tranexamic acid concentration by solid phase microextraction and liquid chromatography-tandem mass spectrometry: first step to in\u00a0vivo analysis","volume":"879","author":"Bojko","year":"2011","journal-title":"J\u00a0Chromatogr B Anal Technol Biomed Life Sci"},{"key":"10.1016\/j.hpb.2016.09.005_bib40","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/j.1365-2044.2012.07266.x","article-title":"Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass","volume":"67","author":"Sharma","year":"2012","journal-title":"Anaesthesia"},{"key":"10.1016\/j.hpb.2016.09.005_bib41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1538-7836.2007.02319.x","article-title":"Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography","volume":"5","author":"Rugeri","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.hpb.2016.09.005_bib42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/jth.12078","article-title":"The incidence and magnitude of fibrinolytic activation in trauma patients","volume":"11","author":"Raza","year":"2013","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.hpb.2016.09.005_bib43","doi-asserted-by":"crossref","first-page":"e3054","DOI":"10.1136\/bmj.e3054","article-title":"Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis","volume":"344","author":"Ker","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.hpb.2016.09.005_bib44","first-page":"CD009052","article-title":"Methods to decrease blood loss and transfusion requirements for liver transplantation","volume":"12","author":"Gurusamy","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.hpb.2016.09.005_bib45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/anae.13270","article-title":"The effect of tranexamic acid on blood coagulation in total hip replacement arthroplasty: rotational thromboelastographic (ROTEM\u00ae) analysis","volume":"71","author":"Na","year":"2016","journal-title":"Anaesthesia"},{"key":"10.1016\/j.hpb.2016.09.005_bib46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/01.mbc.0000252598.25024.68","article-title":"Tranexamic acid does not correct the haemostatic impairment caused by hydroxyethyl starch (200 kDa\/0.5) after cardiac surgery","volume":"17","author":"Kuitunen","year":"2006","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.hpb.2016.09.005_bib47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0971-9784.95072","article-title":"A\u00a0randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130\/0.4) undergoing off pump coronary artery bypass surgery","volume":"15","author":"Chakravarthy","year":"2012","journal-title":"Ann Card Anaesth"},{"key":"10.1016\/j.hpb.2016.09.005_bib48","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/00000539-200105000-00010","article-title":"Plasma tranexamic acid concentrations during cardiopulmonary bypass","volume":"92","author":"Fiechtner","year":"2001","journal-title":"Anesth Analg"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X16318834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X16318834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:07:30Z","timestamp":1761264450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X16318834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1365182X16318834"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2016.09.005","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2016.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}