{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:10:59Z","timestamp":1790655059232,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372674"],"award-info":[{"award-number":["81372674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.hpb.2017.06.011","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T01:46:39Z","timestamp":1500947199000},"page":"951-956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Elevation of CA19-9 and CEA is associated with a poor prognosis in patients with resectable gallbladder carcinoma"],"prefix":"10.1016","volume":"19","author":[{"given":"Zhijian","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anfeng","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhou","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2017.06.011_bib1","first-page":"99","article-title":"Gallbladder cancer: epidemiology and outcome","volume":"6","author":"Hundal","year":"2014","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.hpb.2017.06.011_bib2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrc1429","article-title":"Gallbladder cancer: lessons from a rare tumour","volume":"4","author":"Wistuba","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.hpb.2017.06.011_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejso.2006.10.004","article-title":"Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer","volume":"33","author":"Goonetilleke","year":"2007","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.hpb.2017.06.011_bib4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1477-2574.2009.00149.x","article-title":"Elevated CA 19-9 portends poor prognosis in patients undergoing resection of biliary malignancies","volume":"12","author":"Hatzaras","year":"2010","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2017.06.011_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/1354750X.2014.923048","article-title":"Serum tumor markers in bile duct cancer\u2013a review","volume":"19","author":"Grunnet","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.hpb.2017.06.011_bib6","first-page":"11683","article-title":"Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis","volume":"8","author":"Zhang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.hpb.2017.06.011_bib7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/jclinpath-2014-202451","article-title":"Combination of tumour markers CEA and CA19-9 improves the prognostic prediction in patients with pancreatic cancer","volume":"68","author":"Reitz","year":"2015","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.hpb.2017.06.011_bib8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ijc.2910450505","article-title":"Serum CEA and CA 19-9: potential future diagnostic or screening tests for gallbladder cancer?","volume":"45","author":"Strom","year":"1990","journal-title":"Int J Cancer"},{"key":"10.1016\/j.hpb.2017.06.011_bib9","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American Joint Committee on Cancer: the 7th ed. of the AJCC cancer staging manual and the future of TNM et\u00a0al","volume":"17","author":"Edge","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2017.06.011_bib10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1186\/1471-2407-14-652","article-title":"The prognostic importance of jaundice in surgical resection with curative intent for gallbladder cancer, et\u00a0al","volume":"14","author":"Yang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.hpb.2017.06.011_bib11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/hpb.12444","article-title":"Gallbladder cancer: expert consensus statement","volume":"17","author":"Aloia","year":"2015","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2017.06.011_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.0006-341X.2000.00337.x","article-title":"Time-dependent ROC curves for censored survival data and a diagnostic marker et\u00a0al","volume":"56","author":"Heagerty","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.hpb.2017.06.011_bib13","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.3748\/wjg.v20.i14.4085","article-title":"Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer, et\u00a0al","volume":"20","author":"Wang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hpb.2017.06.011_bib14","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3760\/cma.j.issn.0366-6999.20131734","article-title":"Preoperative prediction of survival in resectable gallbladder cancer by a combined utilization of CA 19-9 and carcinoembryonic antigen et\u00a0al","volume":"127","author":"Yu","year":"2014","journal-title":"Chin Med J"},{"key":"10.1016\/j.hpb.2017.06.011_bib15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.0006-341X.2005.030814.x","article-title":"Survival model predictive accuracy and ROC curves","volume":"61","author":"Heagerty","year":"2005","journal-title":"Biometrics"},{"key":"10.1016\/j.hpb.2017.06.011_bib16","first-page":"378","article-title":"Predictive factors in patients with hepatocellular carcinoma receiving sorafenib therapy using time-dependent receiver operating characteristic analysis","volume":"8","author":"Nishikawa","year":"2017","journal-title":"J\u00a0Cancer"},{"key":"10.1016\/j.hpb.2017.06.011_bib17","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1136\/jcp.2008.059063","article-title":"New time-dependent approach to analyse the prognostic significance of immunohistochemical biomarkers in colon cancer and diffuse large B-cell lymphoma","volume":"62","author":"Adams","year":"2009","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.hpb.2017.06.011_bib18","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1158\/1078-0432.CCR-05-2336","article-title":"Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma","volume":"12","author":"Guo","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.hpb.2017.06.011_bib19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11605-012-2134-9","article-title":"Comparison of the sixth and seventh editions of the AJCC TNM classification for gallbladder cancer","volume":"17","author":"Oh","year":"2013","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.hpb.2017.06.011_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12029-015-9766-4","article-title":"Aggressive surgical approach for gallbladder cancer: a single-center experience from northern India","volume":"46","author":"Singh","year":"2015","journal-title":"J\u00a0Gastrointest Cancer"},{"key":"10.1016\/j.hpb.2017.06.011_bib21","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1200\/JCO.2010.29.3605","article-title":"Best supportive care compared with chemotherapy for unresectable gall bladder cancer: a randomized controlled study","volume":"28","author":"Sharma","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.hpb.2017.06.011_bib22","first-page":"51","article-title":"Neoadjuvant chemoradiotherapy in gallbladder cancer","volume":"132","author":"de Aretxabala","year":"2004","journal-title":"Rev Med Chil"},{"key":"10.1016\/j.hpb.2017.06.011_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s13193-015-0377-0","article-title":"Resection after neoadjuvant chemotherapy in advanced carcinoma of the gallbladder: a retrospective study","volume":"6","author":"Selvakumar","year":"2015","journal-title":"Indian J Surg Oncol"},{"key":"10.1016\/j.hpb.2017.06.011_bib24","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.7314\/APJCP.2016.17.4.2137","article-title":"Radiological downstaging with neoadjuvant therapy in unresectable gall bladder cancer cases","volume":"17","author":"Agrawal","year":"2016","journal-title":"Asian Pac J Cancer Prev"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X17308511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X17308511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:09:22Z","timestamp":1761264562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X17308511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1365182X17308511"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2017.06.011","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevation of CA19-9 and CEA is associated with a poor prognosis in patients with resectable gallbladder carcinoma","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2017.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}