{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:55:31Z","timestamp":1785362131703,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.hpb.2018.09.021","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T19:52:50Z","timestamp":1540324370000},"page":"626-635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Scintigraphic liver function and transient elastography in the assessment of patients with resectable hepatocellular carcinoma"],"prefix":"10.1016","volume":"21","author":[{"given":"Fadi","family":"Rassam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim B.","family":"Olthof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart R.","family":"Takkenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Beuers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz-Josef","family":"Kl\u00fcmpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelof J.","family":"Bennink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krijn P.","family":"van Lienden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Besselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier R.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Verheij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"van Gulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2018.09.021_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11605-012-2048-6","article-title":"New paradigms in post-hepatectomy liver failure","volume":"17","author":"Golse","year":"2013","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1053\/j.gastro.2015.12.041","article-title":"Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma","volume":"150","author":"Bruix","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hpb.2018.09.021_bib3","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A\u00a0model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00534-004-0953-0","article-title":"A\u00a0scoring system for the assessment of the risk of mortality after partial hepatectomy in patients with chronic liver dysfunction","volume":"12","author":"Nagashima","year":"2005","journal-title":"J\u00a0Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1091-255X(02)00370-0","article-title":"Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection","volume":"7","author":"Shoup","year":"2003","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11605-009-1085-2","article-title":"Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection","volume":"14","author":"de Graaf","year":"2010","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib8","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.hpb.2016.06.006","article-title":"Measurement of liver function using hepatobiliary scintigraphy improves risk assessment in patients undergoing major liver resection","volume":"18","author":"Cieslak","year":"2016","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2018.09.021_bib9","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.ejso.2017.08.009","article-title":"Estimation of the future remnant liver function is a better tool to predict post-hepatectomy liver failure than platelet-based liver scores","volume":"43","author":"Chapelle","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.hpb.2018.09.021_bib10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.hpb.2015.08.002","article-title":"Future remnant liver function estimated by combining liver volumetry on magnetic resonance imaging with total liver function on (99m)Tc-mebrofenin hepatobiliary scintigraphy: can this tool predict post-hepatectomy liver failure?","volume":"18","author":"Chapelle","year":"2016","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2018.09.021_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000479477","article-title":"Hypertrophy and liver function in ALPPS: correlation with morbidity and mortality","volume":"33","author":"Kang","year":"2017","journal-title":"Visc Med"},{"key":"10.1016\/j.hpb.2018.09.021_bib12","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.hpb.2017.05.007","article-title":"99mTc-mebrofenin hepatobiliary scintigraphy predicts liver failure following major liver resection for perihilar cholangiocarcinoma","volume":"19","author":"Olthof","year":"2017","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2018.09.021_bib13","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s11605-017-3389-y","article-title":"Dynamic evaluation of liver volume and function in associating liver partition and portal vein ligation for staged hepatectomy","volume":"21","author":"Sparrelid","year":"2017","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13304-017-0481-5","article-title":"Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing","volume":"69","author":"Truant","year":"2017","journal-title":"Updates Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib15","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/SLA.0000000000002150","article-title":"Interstage assessment of remnant liver function in ALPPS using hepatobiliary scintigraphy: prediction of posthepatectomy liver failure and introduction of the HIBA index","volume":"267","author":"Serenari","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib16","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","article-title":"Transient elastography: a new noninvasive method for assessment of hepatic fibrosis","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.hpb.2018.09.021_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the international study group of liver surgery (ISGLS)","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2018.09.021_bib19","first-page":"965","article-title":"Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy","volume":"45","author":"Bennink","year":"2004","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.hpb.2018.09.021_bib20","first-page":"387","article-title":"IODIDA clearance rate: a method for measuring hepatocyte uptake function","volume":"24","author":"Ekman","year":"1992","journal-title":"Transplant Proc"},{"key":"10.1016\/j.hpb.2018.09.021_bib21","first-page":"303","article-title":"A\u00a0formula to estimate the approximate surface area if height and weight be known. 1916","volume":"5","author":"Du Bois","year":"1989","journal-title":"Nutrition"},{"key":"10.1016\/j.hpb.2018.09.021_bib22","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib23","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/hep.27376","article-title":"Liver sinusoidal endothelial cells in hepatic fibrosis","volume":"61","author":"DeLeve","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.pharep.2015.04.010","article-title":"Liver sinusoidal endothelial cells (LSECs) function and NAFLD; NO-based therapy targeted to the liver","volume":"67","author":"Maslak","year":"2015","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.hpb.2018.09.021_bib25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.1840150603","article-title":"Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver","volume":"15","author":"McGuire","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib26","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0002-9440(10)63487-6","article-title":"Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis","volume":"163","author":"Xu","year":"2003","journal-title":"Am J Pathol"},{"issue":"Suppl 2","key":"10.1016\/j.hpb.2018.09.021_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0168-8278(97)80498-9","article-title":"Drug elimination in chronic liver diseases","volume":"26","author":"Huet","year":"1997","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.hpb.2018.09.021_bib28","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/hep.1840180412","article-title":"Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique","volume":"18","author":"Gariepy","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib29","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3748\/wjg.v22.i3.1260","article-title":"Pharmacokinetic drug interactions in liver disease: an update","volume":"22","author":"Palatini","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.hpb.2018.09.021_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbamcr.2006.04.014","article-title":"Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration","volume":"1773","author":"Geier","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.hpb.2018.09.021_bib31","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jhep.2010.07.047","article-title":"Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green","volume":"54","author":"de Graaf","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.hpb.2018.09.021_bib32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1124\/dmd.117.076927","article-title":"Involvement of nuclear factor kappaB, not pregnane X receptor, in inflammation-mediated regulation of hepatic transporters","volume":"45","author":"Abualsunun","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.hpb.2018.09.021_bib33","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1111\/j.1572-0241.2002.06038.x","article-title":"Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection","volume":"97","author":"Regev","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.hpb.2018.09.021_bib34","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","article-title":"Sampling variability of liver fibrosis in chronic hepatitis C","volume":"38","author":"Bedossa","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2018.09.021_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/his.12940","article-title":"Any value in a specialist review of liver biopsies? Conclusions of a 4-year review","volume":"69","author":"Paterson","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.hpb.2018.09.021_bib36","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1053\/j.gastro.2017.03.016","article-title":"American gastroenterological association institute technical review on the role of elastography in chronic liver diseases","volume":"152","author":"Singh","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hpb.2018.09.021_bib37","first-page":"A14","article-title":"Liver stiffness measured by real-time shear wave elastography is a good predictor of liver function","volume":"79","author":"Verlinden","year":"2016"},{"key":"10.1016\/j.hpb.2018.09.021_bib38","first-page":"98","article-title":"Dynamic hepatobiliary SPECT: a method for tomography of a changing radioactivity distribution","volume":"29","author":"Oppenheim","year":"1988","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.hpb.2018.09.021_bib39","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2967\/jnumed.106.038430","article-title":"Risk assessment of posthepatectomy liver failure using hepatobiliary scintigraphy and CT volumetry","volume":"48","author":"Dinant","year":"2007","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.hpb.2018.09.021_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2967\/jnumed.109.069724","article-title":"(99m)Tc-mebrofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy","volume":"51","author":"de Graaf","year":"2010","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.hpb.2018.09.021_bib41","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.surg.2017.05.022","article-title":"Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: liver volume overestimates liver function","volume":"162","author":"Olthof","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2018.09.021_bib42","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/bjs.7456","article-title":"Increase in future remnant liver function after preoperative portal vein embolization","volume":"98","author":"de Graaf","year":"2011","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2018.09.021_bib43","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/BF01297149","article-title":"Hepatocellular carcinoma. A worldwide problem and the major risk factors","volume":"36","author":"Simonetti","year":"1991","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.hpb.2018.09.021_bib44","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s12325-008-0113-z","article-title":"Systemic therapy of hepatocellular carcinoma: are we making progress?","volume":"25","author":"Roxburgh","year":"2008","journal-title":"Adv Ther"},{"key":"10.1016\/j.hpb.2018.09.021_bib45","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.surg.2017.06.006","article-title":"Liver stiffness measurement by transient elastography predicts late posthepatectomy outcomes in patients undergoing resection for hepatocellular carcinoma","volume":"162","author":"Rajakannu","year":"2017","journal-title":"Surgery"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X1834471X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X1834471X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:18:13Z","timestamp":1761265093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X1834471X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1365182X1834471X"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2018.09.021","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scintigraphic liver function and transient elastography in the assessment of patients with resectable hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2018.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}