{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:19:11Z","timestamp":1787649551029,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-EB024135"],"award-info":[{"award-number":["R21-EB024135"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.hpb.2019.01.019","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T11:38:06Z","timestamp":1552563486000},"page":"1344-1353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Normal and fibrotic liver parenchyma respond differently to irreversible electroporation"],"prefix":"10.1016","volume":"21","author":[{"given":"Chenang","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Lopez-Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Rubinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy T.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2019.01.019_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10439-005-8981-8","article-title":"Tissue ablation with irreversible electroporation","volume":"33","author":"Davalos","year":"2005","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.hpb.2019.01.019_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/153303460700600407","article-title":"The effect of irreversible electroporation on blood vessels","volume":"6","author":"Maor","year":"2007","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.hpb.2019.01.019_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/153303460700600106","article-title":"Irreversible electroporation: a new ablation modality--clinical implications","volume":"6","author":"Rubinsky","year":"2007","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.hpb.2019.01.019_bib4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/bjc.2011.582","article-title":"Irreversible electroporation on the small intestine","volume":"106","author":"Phillips","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1016\/j.hpb.2019.01.019_bib5","first-page":"1","article-title":"Non-thermal, pulsed electric field cell ablation: a novel tool for regenerative medicine and scarless skin regeneration","volume":"1","author":"Golberg","year":"2013","journal-title":"Technology (Singap World Sci)"},{"key":"10.1016\/j.hpb.2019.01.019_bib6","doi-asserted-by":"crossref","first-page":"e1571","DOI":"10.7717\/peerj.1571","article-title":"Rat liver regeneration following ablation with irreversible electroporation","volume":"4","author":"Golberg","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.hpb.2019.01.019_bib7","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1158\/0008-5472.CAN-09-3067","article-title":"Irreversible electroporation therapy in the liver: longitudinal efficacy studies in a rat model of hepatocellular carcinoma","volume":"70","author":"Guo","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.hpb.2019.01.019_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1148\/radiol.10090337","article-title":"Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation","volume":"255","author":"Lee","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.hpb.2019.01.019_bib9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bbrc.2013.05.039","article-title":"Changes of apoptosis in tumor tissues with time after irreversible electroporation","volume":"435","author":"Kim","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.hpb.2019.01.019_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.bbrc.2018.04.132","article-title":"Molecular and histological study on the effects of non-thermal irreversible electroporation on the liver","volume":"500","author":"Zhang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.hpb.2019.01.019_bib11","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.2015151166","article-title":"Irreversible electroporation versus radiofrequency ablation: a comparison of local and systemic effects in a small animal model","author":"Bulvik","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.hpb.2019.01.019_bib12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/SLA.0000000000001441","article-title":"Treatment of 200 locally advanced (stage III) pancreatic adenocarcinoma patients with irreversible electroporation: safety and efficacy","volume":"262","author":"Martin","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2019.01.019_bib13","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1245\/s10434-015-5034-x","article-title":"Single-institution experience with irreversible electroporation for T4 pancreatic cancer: first 50 patients","volume":"23","author":"Kluger","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2019.01.019_bib14","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1148\/radiol.2016152835","article-title":"Ablation of locally advanced pancreatic cancer with percutaneous irreversible electroporation: results of the phase I\/II PANFIRE study","volume":"282","author":"Scheffer","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.hpb.2019.01.019_bib15","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1245\/s10434-017-5900-9","article-title":"Induction chemotherapy followed by resection or irreversible electroporation in locally advanced pancreatic cancer (IMPALA): a prospective cohort study","volume":"24","author":"Vogel","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2019.01.019_bib16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1186\/s12885-015-1736-5","article-title":"Colorectal liver metastatic disease: efficacy of irreversible electroporation--a single-arm phase II clinical trial (COLDFIRE-2 trial)","volume":"15","author":"Scheffer","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.hpb.2019.01.019_bib17","doi-asserted-by":"crossref","first-page":"43687","DOI":"10.1038\/srep43687","article-title":"Percutaneous Irreversible Electroporation: long-term survival analysis of 71 patients with inoperable malignant hepatic tumors","volume":"7","author":"Niessen","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.hpb.2019.01.019_bib18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1148\/radiol.2017161413","article-title":"Safety and efficacy of irreversible electroporation for the treatment of hepatocellular carcinoma not amenable to thermal ablation techniques: a retrospective single-center case series","volume":"284","author":"Sutter","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.hpb.2019.01.019_bib19","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ejso.2016.12.004","article-title":"Single-center nonrandomized clinical trial to assess the safety and efficacy of irreversible electroporation (IRE) ablation of liver tumors in humans: short to mid-term results","volume":"43","author":"Fruhling","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.hpb.2019.01.019_bib20","doi-asserted-by":"crossref","first-page":"e015810","DOI":"10.1136\/bmjopen-2016-015810","article-title":"Ablation with irreversible electroporation in patients with advanced perihilar cholangiocarcinoma (ALPACA): a multicentre phase I\/II feasibility study protocol","volume":"7","author":"Coelen","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.hpb.2019.01.019_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/JHC.S129063","article-title":"Irreversible electroporation of hepatocellular carcinoma: patient selection and perspectives","volume":"4","author":"Zimmerman","year":"2017","journal-title":"J\u00a0Hepatocell Carcinoma"},{"key":"10.1016\/j.hpb.2019.01.019_bib22","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s00432-017-2513-4","article-title":"Percutaneous irreversible electroporation combined with allogeneic natural killer cell immunotherapy for patients with unresectable (stage III\/IV) pancreatic cancer: a promising treatment","volume":"143","author":"Lin","year":"2017","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"10.1016\/j.hpb.2019.01.019_bib23","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1159\/000492509","article-title":"Allogenic natural killer cell immunotherapy combined with irreversible electroporation for stage IV hepatocellular carcinoma: survival outcome","volume":"48","author":"Alnaggar","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.hpb.2019.01.019_bib24","doi-asserted-by":"crossref","first-page":"091003","DOI":"10.1115\/1.4001882","article-title":"Nonthermal irreversible electroporation for tissue decellularization","volume":"132","author":"Phillips","year":"2010","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.hpb.2019.01.019_bib25","first-page":"0110041","article-title":"Principles of tissue engineering with nonthermal irreversible electroporation","volume":"133","author":"Phillips","year":"2011","journal-title":"J\u00a0Heat Tran"},{"key":"10.1016\/j.hpb.2019.01.019_bib26","series-title":"Extracellular matrix material created using non-thermal irreversible electroporation","author":"Phillips","year":"2014"},{"key":"10.1016\/j.hpb.2019.01.019_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2144\/000114547","article-title":"Using non-thermal irreversible electroporation to create an in\u00a0vivo niche for exogenous cell engraftment","volume":"62","author":"Chang","year":"2017","journal-title":"BioTechniques"},{"key":"10.1016\/j.hpb.2019.01.019_bib28","doi-asserted-by":"crossref","first-page":"093909","DOI":"10.1063\/1.4999605","article-title":"Modeling dynamics in diseased cardiac tissue: impact of model choice","volume":"27","author":"Gokhale","year":"2017","journal-title":"Chaos"},{"key":"10.1016\/j.hpb.2019.01.019_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0005-2736(95)00194-8","article-title":"Contribution to the biophysics of the lethal effects of electric field on microorganisms","volume":"1278","author":"Kekez","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.hpb.2019.01.019_bib30","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1021\/ac062049e","article-title":"Effect of cell size and shape on single-cell electroporation","volume":"79","author":"Agarwal","year":"2007","journal-title":"Anal Chem"},{"key":"10.1016\/j.hpb.2019.01.019_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10544-013-9820-6","article-title":"Model of pore formation in a single cell in a flow-through channel with micro-electrodes","volume":"16","author":"Kaner","year":"2014","journal-title":"Biomed Microdevices"},{"key":"10.1016\/j.hpb.2019.01.019_bib32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bpj.2017.06.014","article-title":"Enhancing irreversible electroporation by manipulating cellular biophysics with a molecular adjuvant","volume":"113","author":"Ivey","year":"2017","journal-title":"Biophys J"},{"key":"10.1016\/j.hpb.2019.01.019_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12307-008-0011-6","article-title":"The prometastatic microenvironment of the liver","volume":"1","author":"Vidal-Vanaclocha","year":"2008","journal-title":"Cancer Microenviron"},{"key":"10.1016\/j.hpb.2019.01.019_bib34","first-page":"1164","article-title":"Lower incidence of hepatic metastases of colorectal cancer in patients with chronic liver diseases: meta-analysis","volume":"60","author":"Augustin","year":"2013","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.hpb.2019.01.019_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1665-2681(19)31740-5","article-title":"Reversibility of liver fibrosis","volume":"8","author":"Ramachandran","year":"2009","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.hpb.2019.01.019_bib36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bioelechem.2006.10.005","article-title":"In\u00a0vivo electrical impedance measurements during and after electroporation of rat liver","volume":"70","author":"Ivorra","year":"2007","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.hpb.2019.01.019_bib37","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1109\/TBME.2015.2441636","article-title":"The feasibility of a smart surgical probe for verification of IRE treatments using electrical impedance spectroscopy","volume":"62","author":"Bonakdar","year":"2015","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.hpb.2019.01.019_bib38","doi-asserted-by":"crossref","first-page":"10323","DOI":"10.1038\/s41598-017-10846-5","article-title":"Predicting irreversible electroporation-induced tissue damage by means of magnetic resonance electrical impedance tomography","volume":"7","author":"Kranjc","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.hpb.2019.01.019_bib39","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1053\/j.gastro.2009.12.055","article-title":"Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress","volume":"138","author":"Hanada","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hpb.2019.01.019_bib40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2353\/ajpath.2007.061133","article-title":"A\u00a0new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis","volume":"171","author":"Fickert","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.hpb.2019.01.019_bib41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jso.24404","article-title":"Irreversible electroporation in locally advanced pancreatic cancer: a call for standardization of energy delivery","volume":"114","author":"Martin","year":"2016","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.hpb.2019.01.019_bib42","doi-asserted-by":"crossref","first-page":"NP95","DOI":"10.1177\/1533034615601549","article-title":"Electrolytic effects during tissue ablation by electroporation","volume":"15","author":"Rubinsky","year":"2016","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.hpb.2019.01.019_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.hpb.2019.01.019_bib44","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/FJC.0b013e318207a35f","article-title":"Fibrosis and cardiac arrhythmias","volume":"57","author":"de Jong","year":"2011","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.hpb.2019.01.019_bib45","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X19300875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X19300875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:19:35Z","timestamp":1761265175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X19300875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1365182X19300875"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2019.01.019","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Normal and fibrotic liver parenchyma respond differently to irreversible electroporation","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2019.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}