{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:21:46Z","timestamp":1791404506212,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.hpb.2021.08.940","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T12:17:08Z","timestamp":1629289028000},"page":"461-469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Single-center experience of liver transplantation for perihilar cholangiocarcinoma"],"prefix":"10.1016","volume":"24","author":[{"given":"Ola","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Vachharajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-9556","authenticated-orcid":false,"given":"Su-Hsin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-489X","authenticated-orcid":false,"given":"Yikyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel S.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.M.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2021.08.940_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/bjs.6788","article-title":"Disease recurrence patterns after R0 resection of hilar cholangiocarcinoma","volume":"97","author":"Kobayashi","year":"2010","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1001\/archsurg.2011.771","article-title":"Improvement in perioperative and long-term outcome after surgical treatment of hilar cholangiocarcinoma: results of an Italian multicenter analysis of 440 patients","volume":"147","author":"Nuzzo","year":"2012","journal-title":"Arch Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jamcollsurg.2015.01.064","article-title":"Is liver transplantation appropriate for patients with potentially resectable de novo hilar cholangiocarcinoma?","volume":"221","author":"Croome","year":"2015","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00000658-199201000-00005","article-title":"Management strategies in resection for hilar cholangiocarcinoma","volume":"215","author":"Bismuth","year":"1992","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/SLA.0000000000002574","article-title":"Transplantation versus resection for hilar cholangiocarcinoma: an argument for shifting treatment paradigms for resectable disease","volume":"267","author":"Ethun","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/SLA.0b013e3182708b57","article-title":"Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections","volume":"258","author":"Nagino","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/bjs.10556","article-title":"Surgical resection for Bismuth type IV perihilar cholangiocarcinoma","volume":"105","author":"Ebata","year":"2018","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/hpb.12450","article-title":"Hilar cholangiocarcinoma: expert consensus statement","volume":"17","author":"Mansour","year":"2015","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2021.08.940_bib9","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00268-012-1638-5","article-title":"Long-term survival in hilar cholangiocarcinoma also possible in unresectable patients","volume":"36","author":"Ruys","year":"2012","journal-title":"World J Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/lv.2000.6143","article-title":"Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma","volume":"6","author":"De Vreede","year":"2000","journal-title":"Liver Transplant"},{"key":"10.1016\/j.hpb.2021.08.940_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-2004-828896","article-title":"Liver transplantation for unresectable perihilar cholangiocarcinoma","volume":"24","author":"Heimbach","year":"2004","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.hpb.2021.08.940_bib12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.sla.0000179678.13285.fa","article-title":"Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma","volume":"242","author":"Rea","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/hpb.12450","article-title":"Hilar cholangiocarcinoma: expert consensus statement","volume":"17","author":"Mansour","year":"2015","journal-title":"HPB\u202f: the official journal of the International Hepato Pancreato Biliary Association"},{"key":"10.1016\/j.hpb.2021.08.940_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.soc.2019.06.003","article-title":"Surgical considerations of hilar cholangiocarcinoma","volume":"28","author":"Anderson","year":"2019","journal-title":"Surg Oncol Clin"},{"key":"10.1016\/j.hpb.2021.08.940_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jamcollsurg.2015.01.061","article-title":"Donor age-based analysis of liver transplantation outcomes: short-and long-term outcomes are similar regardless of donor age","volume":"221","author":"Chapman","year":"2015","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/lt.500040314","article-title":"Use of infrarenal conduits for arterial revascularization in orthotopic liver transplantation","volume":"4","author":"Muiesan","year":"1998","journal-title":"Liver Transplant Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib17","first-page":"490","article-title":"Alternative methods of arterialization of the hepatic graft","volume":"159","author":"Shaw","year":"1984","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.hpb.2021.08.940_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.amjsurg.2012.11.020","article-title":"Correlation of staging systems to survival in patients with resected hilar cholangiocarcinoma","volume":"206","author":"Zaydfudim","year":"2013","journal-title":"Am J Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib19","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1007\/s11605-012-1960-0","article-title":"Surgical outcomes and predicting factors of curative resection in patients with hilar cholangiocarcinoma: 10-year single-institution experience","volume":"16","author":"Cho","year":"2012","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14701\/ahbps.2020.24.1.1","article-title":"Hepatobiliary and pancreatic surgery in the elderly: current status","volume":"24","author":"Papis","year":"2020","journal-title":"Ann Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00000658-200110000-00010","article-title":"Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma","volume":"234","author":"Jarnagin","year":"2001","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/SLA.0b013e3181be0085","article-title":"Aggressive surgical resection for hilar cholangiocarcinoma of the left-side predominance: radicality and safety of left-sided hepatectomy","volume":"251","author":"Shimizu","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220527","article-title":"Comparison between liver transplantation and resection for hilar cholangiocarcinoma: a systematic review and meta-analysis","volume":"14","author":"Moris","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.hpb.2021.08.940_bib24","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1034\/j.1600-6143.2002.20812.x","article-title":"Radiochemotherapy and transplantation allow long-term survival for nonresectable hilar cholangiocarcinoma","volume":"2","author":"Sudan","year":"2002","journal-title":"Am J Transplant"},{"key":"10.1016\/j.hpb.2021.08.940_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/lt.23757","article-title":"Neoadjuvant stereotactic body radiation therapy, capecitabine, and liver transplantation for unresectable hilar cholangiocarcinoma","volume":"20","author":"Welling","year":"2014","journal-title":"Liver Transplant"},{"key":"10.1016\/j.hpb.2021.08.940_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/lt.21287","article-title":"Long-term, tumor-free survival after radiotherapy combining hepatectomy-Whipple en bloc and orthotopic liver transplantation for early-stage hilar cholangiocarcinoma","volume":"14","author":"Wu","year":"2008","journal-title":"Liver Transplant"},{"key":"10.1016\/j.hpb.2021.08.940_bib27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/13651820801992542","article-title":"Surgery for cholangiocarcinoma: the role of liver transplantation","volume":"10","author":"Rosen","year":"2008","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2021.08.940_bib28","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/lt.21107","article-title":"Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma","volume":"13","author":"Mantel","year":"2007","journal-title":"Liver Transplant"},{"key":"10.1016\/j.hpb.2021.08.940_bib29","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/hep.25629","article-title":"Predictors of pretransplant dropout and posttransplant recurrence in patients with perihilar cholangiocarcinoma","volume":"56","author":"Darwish Murad","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2021.08.940_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156127","article-title":"Strict selection alone of patients undergoing liver transplantation for hilar cholangiocarcinoma is associated with improved survival","volume":"11","author":"Mantel","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.hpb.2021.08.940_bib31","series-title":"Blumgart\u2019s surgery of the liver, biliary tract, and pancreas","first-page":"1712","article-title":"Liver transplantation for cholangiocarcinoma and other neoplastic diseases","author":"Burns","year":"2012"},{"key":"10.1016\/j.hpb.2021.08.940_bib32","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jamcollsurg.2005.07.011","article-title":"Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma","volume":"201","author":"Corvera","year":"2005","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.gastro.2012.04.008","article-title":"Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers","volume":"143","author":"Darwish Murad","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.hpb.2021.08.940_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jamcollsurg.2012.03.014","article-title":"Neoadjuvant therapy and liver transplantation for hilar cholangiocarcinoma: is pretreatment pathological confirmation of diagnosis necessary?","volume":"215","author":"Rosen","year":"2012","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.hpb.2021.08.940_bib35","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1572-0241.2001.03696.x","article-title":"Treatment of cholangiocarcinoma complicating primary sclerosing cholangitis: the Mayo Clinic experience","volume":"96","author":"Kaya","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.hpb.2021.08.940_bib36","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1432-2277.2010.01108.x","article-title":"Liver transplantation for cholangiocarcinoma","volume":"23","author":"Rosen","year":"2010","journal-title":"Transpl Int"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X21015847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X21015847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:37:32Z","timestamp":1761266252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X21015847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1365182X21015847"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2021.08.940","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-center experience of liver transplantation for perihilar cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2021.08.940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.","name":"copyright","label":"Copyright"}]}}