{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:31:04Z","timestamp":1788571864131,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.hpb.2023.12.001","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T22:01:27Z","timestamp":1702159287000},"page":"418-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Calcium channel blockers are associated with improved survival in pancreatic cancer patients undergoing neoadjuvant chemotherapy and resection"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-413X","authenticated-orcid":false,"given":"Zhi V.","family":"Fong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-2535","authenticated-orcid":false,"given":"George","family":"Severs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-4713","authenticated-orcid":false,"given":"John","family":"Moir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-9853","authenticated-orcid":false,"given":"Steve","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-8308","authenticated-orcid":false,"given":"Motaz","family":"Qadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5529-7815","authenticated-orcid":false,"given":"Samuel","family":"Tingle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2023.12.001_bib1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.1031","article-title":"National trends in the use of neoadjuvant therapy before cancer surgery in the US from 2004 to 2016","volume":"4","author":"Aquina","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.hpb.2023.12.001_bib2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hpb.2023.12.001_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9041129","article-title":"Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer: a meta-analysis of randomized controlled trials","volume":"9","author":"Cloyd","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.hpb.2023.12.001_bib4","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrclinonc.2015.169","article-title":"Drug repurposing in oncology--patient and health systems opportunities","volume":"12","author":"Bertolini","year":"2015","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.hpb.2023.12.001_bib5","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.2174\/0929867325666180713155702","article-title":"Drug repurposing in the development of anticancer agents","volume":"26","author":"Olgen","year":"2019","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.hpb.2023.12.001_bib6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.drudis.2021.11.012","article-title":"Targeting Ca2+ signaling: a new arsenal against cancer","volume":"27","author":"Panda","year":"2022","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.hpb.2023.12.001_bib7","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.3390\/cancers14112703","article-title":"Combinatorial therapy of cancer: possible advantages of involving modulators of ionic mechanisms","volume":"14","author":"Djamgoz","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.hpb.2023.12.001_bib8","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.2147\/CMAR.S228718","article-title":"Anticancer effects of antihypertensive L-type calcium channel blockers on chemoresistant lung cancer cells via autophagy and apoptosis","volume":"12","author":"Wong","year":"2020","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.hpb.2023.12.001_bib9","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1245\/s10434-021-09645-0","article-title":"Amlodipine and verapamil, voltage-gated Ca2+ channel inhibitors, Suppressed the Growth of gastric cancer stem cells","volume":"28","author":"Shiozaki","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2023.12.001_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108327","article-title":"Calcium Channel blocker nifedipine suppresses colorectal cancer progression and immune escape by preventing NFAT2 nuclear translocation","volume":"33","author":"Wu","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.hpb.2023.12.001_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118291","article-title":"T-type calcium channel antagonist, TTA-A2 exhibits anti-cancer properties in 3D spheroids of A549, a lung adenocarcinoma cell line","volume":"260","author":"Kumari","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.hpb.2023.12.001_bib12","first-page":"1027","article-title":"Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia","volume":"14","author":"Shchepotin","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1016\/j.hpb.2023.12.001_bib13","first-page":"469","article-title":"Combination therapy with cisplatin and nifedipine inducing apoptosis in multidrug-resistant human glioblastoma cells","volume":"82","author":"Kondo","year":"1995","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.hpb.2023.12.001_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200143119","article-title":"Calcium channel blockers potentiate gemcitabine chemotherapy in pancreatic cancer","volume":"119","author":"Principe","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hpb.2023.12.001_bib15","doi-asserted-by":"crossref","first-page":"35931","DOI":"10.18632\/oncotarget.5933","article-title":"Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and \u03b2-catenin signaling","volume":"6","author":"Woods","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.hpb.2023.12.001_bib16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/mol.65.3.630","article-title":"Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro","volume":"65","author":"J\u00e4ger","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.hpb.2023.12.001_bib17","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.hpb.2023.12.001_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/cancers11030376","article-title":"Ion channels: new actors playing in chemotherapeutic resistance","volume":"11","author":"Kischel","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.hpb.2023.12.001_bib19","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.bbamcr.2014.02.012","article-title":"Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma","volume":"1843","author":"Kondratska","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.hpb.2023.12.001_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118518","article-title":"Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein","volume":"262","author":"El-Mahdy","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.hpb.2023.12.001_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/ijo.2016.3512","article-title":"Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells","volume":"49","author":"Zhao","year":"2016","journal-title":"Int J Oncol"},{"key":"10.1016\/j.hpb.2023.12.001_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4291\/wjgp.v6.i4.235","article-title":"Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma","volume":"6","author":"Tingle","year":"2015","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.hpb.2023.12.001_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/CAD.0000000000000947","article-title":"Calcium channel blockers in pancreatic cancer: increased overall survival in a retrospective cohort study","volume":"31","author":"Tingle","year":"2020","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.hpb.2023.12.001_bib24","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2017.35.15_suppl.e15756","article-title":"Calcium channel blockers use and overall survival in pancreatic cancer patients receiving gemcitabine","volume":"35","author":"Kraj","year":"2017","journal-title":"J Clin Oncol"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X23020087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X23020087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:44:47Z","timestamp":1761266687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X23020087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1365182X23020087"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2023.12.001","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium channel blockers are associated with improved survival in pancreatic cancer patients undergoing neoadjuvant chemotherapy and resection","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2023.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.","name":"copyright","label":"Copyright"}]}}