{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:38:22Z","timestamp":1774341502001,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K11928"],"award-info":[{"award-number":["JP24K11928"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.hpb.2024.12.005","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T02:44:34Z","timestamp":1734057874000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reappraisal of carcinoma in situ residue at the bile duct margin: a single-center review of 681 patients with perihilar cholangiocarcinoma"],"prefix":"10.1016","volume":"27","author":[{"given":"Ryusei","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-5586","authenticated-orcid":false,"given":"Shunsuke","family":"Onoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-1188","authenticated-orcid":false,"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-4480","authenticated-orcid":false,"given":"Nobuyuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-552X","authenticated-orcid":false,"given":"Shoji","family":"Kawakatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-1964","authenticated-orcid":false,"given":"Masaki","family":"Sunagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-5271","authenticated-orcid":false,"given":"Junpei","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-1806","authenticated-orcid":false,"given":"Atsushi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-7396","authenticated-orcid":false,"given":"Taisuke","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2049-6704","authenticated-orcid":false,"given":"Tsuyoshi","family":"Igami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-7050","authenticated-orcid":false,"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2024.12.005_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/SLA.0b013e3182708b57","article-title":"Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections","volume":"258","author":"Nagino","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib2","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/cncr.20906","article-title":"Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma","volume":"103","author":"Wakai","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.hpb.2024.12.005_bib3","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1245\/s10434-008-0003-2","article-title":"Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma","volume":"15","author":"Endo","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2024.12.005_bib4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jhbp.481","article-title":"High-grade dysplasia\/carcinoma in situ of the bile duct margin in patients with surgically resected node-negative perihilar cholangiocarcinoma is associated with poor survival: a retrospective study","volume":"24","author":"Higuchi","year":"2017","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hpb.2024.12.005_bib5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/SLA.0b013e3182368f85","article-title":"Additional resection of an intraoperative margin-positive proximal bile duct improves survival in patients with hilar cholangiocarcinoma","volume":"254","author":"Ribero","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib6","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/bjs.11125","article-title":"Clinical value of additional resection of a margin-positive distal bile duct in perihilar cholangiocarcinoma","volume":"106","author":"Otsuka","year":"2019","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/SLA.0000000000003305","article-title":"A\u00a0study on radial margin status in resected perihilar cholangiocarcinoma","volume":"273","author":"Shinohara","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/SLA.0b013e318190a647","article-title":"Clinicopathologic study of cholangiocarcinoma with superficial spread","volume":"249","author":"Igami","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s00534-009-0127-1","article-title":"Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma","volume":"17","author":"Nakanishi","year":"2010","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hpb.2024.12.005_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.surg.2009.11.018","article-title":"Prognostic relevance of ductal margins in operative resection of bile duct cancer","volume":"148","author":"Higuchi","year":"2010","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2024.12.005_bib11","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/bjs.7122","article-title":"Clinical impact of intraoperative histological examination of the ductal resection margin in extrahepatic cholangiocarcinoma","volume":"97","author":"Konishi","year":"2010","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib12","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1245\/s10434-014-4232-2","article-title":"Optimal indications for additional resection of the invasive cancer-positive proximal bile duct margin in cases of advanced perihilar cholangiocarcinoma","volume":"22","author":"Oguro","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2024.12.005_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/SLA.0000000000001944","article-title":"Residual carcinoma in situ at the ductal stump has a negative survival effect: an analysis of early-stage cholangiocarcinomas","volume":"266","author":"Tsukahara","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2024.12.005_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00595-016-1354-0","article-title":"Adjuvant gemcitabine monotherapy for resectable perihilar cholangiocarcinoma with lymph node involvement: a propensity score matching analysis","volume":"47","author":"Mizuno","year":"2017","journal-title":"Surg Today"},{"key":"10.1016\/j.hpb.2024.12.005_bib15","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1245\/s10434-020-08355-3","article-title":"Phase 2 trial of adjuvant chemotherapy with S - 1 for node-positive biliary tract cancer (N-SOG 09)","volume":"27","author":"Seita","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2024.12.005_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/jhbp.1219","article-title":"Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401- MITSUBA)","volume":"30","author":"Ioka","year":"2023","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hpb.2024.12.005_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00535-013-0810-5","article-title":"Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia","volume":"49","author":"Sato","year":"2014","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.hpb.2024.12.005_bib18","series-title":"American Joint committee on cancer (AJCC), cancer staging manual","author":"Amin","year":"2017"},{"key":"10.1016\/j.hpb.2024.12.005_bib19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/hpb.12193","article-title":"Clinicopathological analysis and prognosis of extrahepatic bile duct cancer with a microscopic positive ductal margin","volume":"16","author":"Han","year":"2014","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2024.12.005_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1349-7006.2008.01009.x","article-title":"Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma","volume":"100","author":"Ojima","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.hpb.2024.12.005_bib21","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.hpb.2021.03.004","article-title":"A\u00a0clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases","volume":"23","author":"Onoe","year":"2021","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2024.12.005_bib22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/jhbp.1269","article-title":"Is a specific T classification needed for extrahepatic intraductal papillary neoplasm of the bile duct (IPNB) type 2 associated with invasive carcinoma?","volume":"30","author":"Mitake","year":"2023","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hpb.2024.12.005_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1470-2045(18)30915-X","article-title":"Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study","volume":"20","author":"Primrose","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.hpb.2024.12.005_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0140-6736(22)02038-4","article-title":"Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial","volume":"401","author":"Nakachi","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.hpb.2024.12.005_bib25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/jhbp.1307","article-title":"Volume- and quality-controlled certification system promotes centralization of complex hepato-pancreatic-biliary surgery","volume":"30","author":"Mise","year":"2023","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X24024523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X24024523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:37:02Z","timestamp":1772325422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X24024523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1365182X24024523"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2024.12.005","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reappraisal of carcinoma in situ residue at the bile duct margin: a single-center review of 681 patients with perihilar cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2024.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}