{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:42:07Z","timestamp":1789497727403,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.hpb.2026.04.454","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:10:05Z","timestamp":1777129805000},"page":"966-975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prehabilitation is associated with a reduced incidence of postoperative delirium in patients undergoing pancreatoduodenectomy: a propensity score-matched cohort study"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8780-6888","authenticated-orcid":false,"given":"Heleen","family":"Driessens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-4715","authenticated-orcid":false,"given":"Allard G.","family":"Wijma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1161-4166","authenticated-orcid":false,"given":"Carolien J.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"van Munster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost M.","family":"Klaase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Trzpis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2026.04.454_bib1","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1097\/SLA.0000000000003835","article-title":"Impact of complications after pancreatoduodenectomy on mortality, organ failure, hospital stay, and readmission","volume":"275","author":"Smits","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/SLA.0000000000005628","article-title":"Outcome of pancreatic surgery during the first 6 years of a mandatory audit within the Dutch pancreatic cancer group","volume":"278","author":"Suurmeijer","year":"2023","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib3","series-title":"Diagnostic and statistical manual of mental disorders: DSM-5","year":"2013"},{"key":"10.1016\/j.hpb.2026.04.454_bib4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s00595-022-02614-4","article-title":"Incidence and risk factors of postoperative delirium after pancreatic cancer surgery: a retrospective study","volume":"53","author":"Zhao","year":"2023","journal-title":"Surg Today"},{"key":"10.1016\/j.hpb.2026.04.454_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000446928","article-title":"Postoperative delirium in patients after pancreaticoduodenectomy","volume":"34","author":"Ito","year":"2017","journal-title":"Dig Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib6","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1245\/s10434-024-15358-x","article-title":"The role of delirium on Short- and long-term postoperative outcomes following major gastrointestinal surgery for cancer","volume":"31","author":"Katayama","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2026.04.454_bib7","doi-asserted-by":"crossref","first-page":"111221","DOI":"10.1016\/j.jclinane.2023.111221","article-title":"Association between postoperative delirium and adverse outcomes in older surgical patients: a systematic review and meta-analysis","volume":"90","author":"Yan","year":"2023","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.hpb.2026.04.454_bib8","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1016\/S2666-7568(23)00098-3","article-title":"Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort","volume":"4","author":"Krogseth","year":"2023","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.hpb.2026.04.454_bib9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/gps.4832","article-title":"Development of dementia in patients with femoral neck fracture who experience postoperative delirium-A three-year follow-up study","volume":"33","author":"Olofsson","year":"2018","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.hpb.2026.04.454_bib10","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.hpb.2026.04.454_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.bja.2020.06.063","article-title":"Postoperative delirium: perioperative assessment, risk reduction, and management","volume":"125","author":"Jin","year":"2020","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.hpb.2026.04.454_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136071","article-title":"Risk factors and outcomes for postoperative delirium after major surgery in elderly patients","volume":"10","author":"Raats","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.hpb.2026.04.454_bib13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.surg.2016.09.010","article-title":"Risk factors for postoperative delirium after colorectal operation","volume":"161","author":"van der Sluis","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.04.454_bib14","article-title":"Swimming exercise pretreatment attenuates postoperative delirium-like behavior in type 2 diabetic rats by enhancing mitochondrial biogenesis through activation of SIRT2 deacetylation","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.hpb.2026.04.454_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bja.2021.04.033","article-title":"Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis","volume":"127","author":"Noah","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.hpb.2026.04.454_bib16","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.16780.1","article-title":"Recent advances in preventing and managing postoperative delirium","volume":"8","author":"Vlisides","year":"2019","journal-title":"F1000Res"},{"key":"10.1016\/j.hpb.2026.04.454_bib17","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41590-020-00812-1","article-title":"Neuroinflammation after surgery: from mechanisms to therapeutic targets","volume":"21","author":"Yang","year":"2020","journal-title":"Nat Immunol"},{"key":"10.1016\/j.hpb.2026.04.454_bib18","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.lpm.2018.03.011","article-title":"Impact on the brain of the inflammatory response to surgery","volume":"47","author":"Saxena","year":"2018","journal-title":"Presse Med"},{"key":"10.1016\/j.hpb.2026.04.454_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.surg.2014.09.009","article-title":"Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review","volume":"157","author":"Watt","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.04.454_bib20","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1038\/s41598-024-82992-6","article-title":"Cytokines and inflammatory biomarkers and their association with post-operative delirium: a meta-analysis and systematic review","volume":"15","author":"Mosharaf","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.hpb.2026.04.454_bib21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/nicc.12780","article-title":"Effects of non-pharmacologic prevention on delirium in critically ill patients: a network meta-analysis","volume":"28","author":"Matsuura","year":"2023","journal-title":"Nurs Crit Care"},{"key":"10.1016\/j.hpb.2026.04.454_bib22","first-page":"23","article-title":"Interventions for preventing delirium in older people in institutional long-term care","volume":"4","author":"Woodhouse","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.hpb.2026.04.454_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4037\/ccn2017531","article-title":"Implementing a multicomponent intervention to prevent delirium among critically ill patients","volume":"37","author":"Mart\u00ednez","year":"2017","journal-title":"Crit Care Nurse"},{"key":"10.1016\/j.hpb.2026.04.454_bib24","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1001\/amajethics.2023.751","article-title":"Why we must prevent and appropriately manage delirium","volume":"25","author":"Connell","year":"2023","journal-title":"AMA J Ethics"},{"key":"10.1016\/j.hpb.2026.04.454_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2147\/CIA.S420861","article-title":"The potential value of prehabilitation for preventing delirium in elective surgery for aneurysms of the abdominal aorta","volume":"19","author":"Meulenbroek","year":"2024","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.hpb.2026.04.454_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218152","article-title":"Multimodal prehabilitation to reduce the incidence of delirium and other adverse events in elderly patients undergoing elective major abdominal surgery: an uncontrolled before-and-after study","volume":"14","author":"Janssen","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.hpb.2026.04.454_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/anae.14505","article-title":"Multi-modal prehabilitation: addressing the why, when, what, how, who and where next?","volume":"74","author":"Scheede-Bergdahl","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.hpb.2026.04.454_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40520-017-0875-8","article-title":"Prehabilitation: a new area of integration between geriatricians, anesthesiologists, and exercise therapists","volume":"30","author":"Carli","year":"2018","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.hpb.2026.04.454_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13102-025-01094-6","article-title":"Understanding the mechanism behind preoperative exercise therapy in patients with gastrointestinal cancers: a prospective randomized clinical trial","volume":"17","author":"Hamad","year":"2025","journal-title":"BMC Sports Sci Med Rehabil"},{"key":"10.1016\/j.hpb.2026.04.454_bib30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1139\/apnm-2022-0272","article-title":"Potential mechanisms of multimodal prehabilitation effects on surgical complications: a narrative review","volume":"48","author":"Sibley","year":"2023","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.hpb.2026.04.454_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/ALN.0000000000000698","article-title":"Prehabilitation for prevention of postoperative cognitive dysfunction?","volume":"123","author":"Culley","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.hpb.2026.04.454_bib32","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.hpb.2023.07.899","article-title":"Personalized multimodal prehabilitation reduces cardiopulmonary complications after pancreatoduodenectomy: results of a propensity score matching analysis","volume":"25","author":"Wijma","year":"2023","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2026.04.454_bib33","article-title":"Pylorus-preserving versus pylorus-resecting pancreaticoduodenectomy for periampullary and pancreatic carcinoma: a meta-analysis","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.hpb.2026.04.454_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13741-020-00175-z","article-title":"A prospective cohort study evaluating screening and assessment of six modifiable risk factors in HPB cancer patients and compliance to recommended prehabilitation interventions","volume":"10","author":"van Wijk","year":"2021","journal-title":"Perioper Med"},{"key":"10.1016\/j.hpb.2026.04.454_bib35","first-page":"111","article-title":"Prehabilitation: tertiary prevention matters","author":"Driessens","year":"2024","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib36","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00134-008-1091-y","article-title":"Computer-assisted glucose control in critically ill patients","volume":"34","author":"Vogelzang","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.hpb.2026.04.454_bib37","first-page":"A8491","article-title":"[Predictive value of the VMS theme \u2018Frail elderly\u2019: delirium, falling and mortality in elderly hospital patients]","volume":"159","author":"Oud","year":"2015","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1016\/j.hpb.2026.04.454_bib38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2147\/CIA.S201323","article-title":"Prevention of postoperative delirium in elderly patients planned for elective surgery: systematic review and meta-analysis","volume":"14","author":"Janssen","year":"2019","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.hpb.2026.04.454_bib39","series-title":"American Society of anesthesiologists classification","author":"Doyle","year":"2024"},{"key":"10.1016\/j.hpb.2026.04.454_bib40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis [Internet]"},{"key":"10.1016\/j.hpb.2026.04.454_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib42","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1532-5415.2005.53120.x","article-title":"A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method","volume":"53","author":"Inouye","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.hpb.2026.04.454_bib43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jso.24811","article-title":"Incidence and predictors of postoperative delirium after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy","volume":"117","author":"Plas","year":"2018","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.hpb.2026.04.454_bib44","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jvs.2024.10.024","article-title":"Prehabilitation for delirium prevention in elderly patients with chronic limb threatening ischemia","volume":"81","author":"Meulenbroek","year":"2025","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.109563","article-title":"Multimodal prehabilitation to improve functional abilities and reduce the chronic inflammatory response of frail elderly patients with gastric cancer: a prospective cohort study","volume":"51","author":"Sun","year":"2025","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.hpb.2026.04.454_bib46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s12876-024-03490-7","article-title":"Prognostic impact of a 3-week multimodal prehabilitation program on frail elderly patients undergoing elective gastric cancer surgery: a randomized trial","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.hpb.2026.04.454_bib47","first-page":"1101","article-title":"The geriatric patient: frailty, prehabilitation, and postoperative delirium","volume":"108","author":"Soares","year":"2024","journal-title":"Med Clin"},{"key":"10.1016\/j.hpb.2026.04.454_bib48","series-title":"Implementatie VMS Veiligheidsprogramma: evaluatieonderzoek in Nederlandse ziekenhuizen","author":"de Blok","year":"2013"},{"key":"10.1016\/j.hpb.2026.04.454_bib49","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/SLA.0000000000002480","article-title":"Pylorus resection does not reduce delayed gastric emptying after partial pancreatoduodenectomy: a blinded randomized controlled trial (PROPP study, DRKS00004191)","volume":"267","author":"Hackert","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.04.454_bib50","doi-asserted-by":"crossref","DOI":"10.1097\/AS9.0000000000000458","article-title":"How to reduce delayed gastric emptying after pancreatoduodenectomy: a systematic literature review and meta-analysis","volume":"5","author":"Rebelo","year":"2024","journal-title":"Ann Surg Open"},{"key":"10.1016\/j.hpb.2026.04.454_bib51","doi-asserted-by":"crossref","first-page":"104518","DOI":"10.1016\/j.archger.2021.104518","article-title":"Consistent patterns in the inconsistent associations of insulin-like growth factor 1 (IGF-1), C-Reactive Protein (C-RP) and Interleukin 6 (IL-6) levels with delirium in surgical populations. A systematic review and meta-analysis","volume":"97","author":"Adamis","year":"2021","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.hpb.2026.04.454_bib52","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1055\/s-0044-1791666","article-title":"The pathophysiology and biomarkers of delirium","volume":"44","author":"Smith","year":"2024","journal-title":"Semin Neurol"},{"key":"10.1016\/j.hpb.2026.04.454_bib53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-022-02483-1","article-title":"Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders","volume":"19","author":"Liu","year":"2022","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.hpb.2026.04.454_bib54","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s40279-024-02072-7","article-title":"Mitochondria as nutritional targets to maintain muscle health and physical function during ageing","volume":"54","author":"Broome","year":"2024","journal-title":"Sports Med"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X2600599X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X2600599X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:23:07Z","timestamp":1783477387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X2600599X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1365182X2600599X"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2026.04.454","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prehabilitation is associated with a reduced incidence of postoperative delirium in patients undergoing pancreatoduodenectomy: a propensity score-matched cohort study","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2026.04.454","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.","name":"copyright","label":"Copyright"}]}}