{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:52:14Z","timestamp":1791503534909,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.hpb.2026.06.021","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:47:42Z","timestamp":1783147662000},"page":"1413-1419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trans-anastomotic stent does not impact the predictive value of drain fluid amylase after pancreatoduodenectomy"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-7114","authenticated-orcid":false,"given":"Giampaolo","family":"Perri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-9978","authenticated-orcid":false,"given":"Aya","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-4226","authenticated-orcid":false,"given":"Isabella","family":"Frigerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0597-9360","authenticated-orcid":false,"given":"Riccardo","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4308-1359","authenticated-orcid":false,"given":"Alice","family":"Cattelani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-5781","authenticated-orcid":false,"given":"Alessandro","family":"Giardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Butturini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-4533","authenticated-orcid":false,"given":"Giovanni","family":"Marchegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2026.06.021_bib1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jamcollsurg.2015.07.005","article-title":"Drain management after pancreatoduodenectomy: reappraisal of a prospective randomized trial using risk stratification","volume":"221","author":"McMillan","year":"2015","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/SLA.0000000000000460","article-title":"A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage","volume":"259","author":"Van Buren","year":"2014","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/SLA.0000000000001859","article-title":"No need for routine drainage after pancreatic head resection: the Dual-Center, randomized, controlled PANDRA trial (ISRCTN04937707)","volume":"264","author":"Witzigmann","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/jamasurg.2016.5708","article-title":"Management of severe pancreatic fistula after pancreatoduodenectomy","volume":"152","author":"Smits","year":"2017","journal-title":"JAMA Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib5","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.surg.2021.01.010","article-title":"Management of postoperative pancreatic fistula after pancreatoduodenectomy: analysis of 600 cases of pancreatoduodenectomy patients over a 10-year period at a single institution","volume":"169","author":"Nakata","year":"2021","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/SLA.0000000000006429","article-title":"Who do we fail to rescue after pancreatoduodenectomy? Outcomes among >4000 procedures expose windows of opportunity","volume":"283","author":"Kinny-Koster","year":"2026","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/SLA.0000000000006513","article-title":"Dynamic assessment of drain fluid amylase estimates the risk of CR-POPF following pancreatoduodenectomy","volume":"283","author":"AlMasri","year":"2026","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib8","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1007\/s11605-023-05863-x","article-title":"Evaluation and recalibration of risk-stratified pancreatoduodenectomy drain fluid amylase removal criteria","volume":"27","author":"Boyev","year":"2023","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/SLA.0000000000002327","article-title":"Characterization and optimal management of high-risk pancreatic anastomoses during pancreatoduodenectomy","volume":"267","author":"Ecker","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2022.106707","article-title":"Does pancreatic duct stent placement lead to decreased postoperative pancreatic fistula rates after pancreaticoduodenectomy? A meta-analysis","volume":"103","author":"Guo","year":"2022","journal-title":"Int J Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/SLA.0b013e31821219af","article-title":"External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy: prospective multicenter randomized trial","volume":"253","author":"Pessaux","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.ijsu.2014.06.008","article-title":"External pancreatic duct stent reduces pancreatic fistula: a meta-analysis and systematic review","volume":"12","author":"Patel","year":"2014","journal-title":"Int J Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12876-025-03700-w","article-title":"The impact of pancreatic duct stent placement on the clinically relevant postoperative pancreatic fistula rate for high-risk anastomoses: a systematic review and meta-analysis","volume":"25","author":"Dai","year":"2025","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.hpb.2026.06.021_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.amjsurg.2024.04.002","article-title":"Stent placement for the prevention of clinically-relevant postoperative pancreatic fistula following pancreaticojejunostomy: a systematic review and meta-analysis","volume":"234","author":"Sun","year":"2024","journal-title":"Am J Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib15","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.gassur.2006.07.020","article-title":"Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial","volume":"10","author":"Winter","year":"2006","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/bjs.8654","article-title":"Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy","volume":"99","author":"Motoi","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/SLA.0000000000006313","article-title":"Somatostatin versus octreotide for prevention of postoperative pancreatic fistula: the PREFIPS randomized clinical trial: a FRENCH 007-ACHBT Study","volume":"280","author":"Gaujoux","year":"2024","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.surg.2023.09.049","article-title":"Extended antibiotic therapy is associated with a lower rate of clinically relevant postoperative pancreatic fistula after pancreatoduodenectomy in intermediate- and high-risk patients: a single-institution analysis","volume":"175","author":"Ocuin","year":"2024","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib19","doi-asserted-by":"crossref","first-page":"e597","DOI":"10.1097\/SLA.0000000000004855","article-title":"A simple classification of pancreatic duct size and texture predicts postoperative pancreatic fistula: a classification of the International Study Group of pancreatic surgery","volume":"277","author":"Schuh","year":"2023","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/SLA.0000000000006481","article-title":"Prospective validation of the pancreatic fistula risk classification by the International Study Group for pancreatic surgery (PARIS trial)","volume":"283","author":"Schuh","year":"2026","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.hpb.2020.10.025","article-title":"Pros and pitfalls of trans-anastomotic stent as a mitigation strategy of POPF: a prospective risk-stratified observational series","volume":"23","author":"Andrianello","year":"2021","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hpb.2026.06.021_bib22","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s11605-020-04658-8","article-title":"Redefining the role of drain amylase value for a risk-based drain management after pancreaticoduodenectomy: early drain removal still is beneficial","volume":"25","author":"Salvia","year":"2021","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/jamasurg.2019.6035","article-title":"Pancreaticojejunostomy with externalized stent vs pancreaticogastrostomy with externalized stent for patients with high-risk pancreatic anastomosis: a single-center, phase 3, randomized clinical trial","volume":"155","author":"Andrianello","year":"2020","journal-title":"JAMA Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","article-title":"The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after","volume":"161","author":"Bassi","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","article-title":"The Clavien-Dindo classification of surgical complications: five-year experience","volume":"250","author":"Clavien","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.surg.2007.02.001","article-title":"Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","article-title":"Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.surg.2016.06.058","article-title":"Definition and classification of chyle leak after pancreatic operation: a consensus statement by the International Study Group on Pancreatic Surgery","volume":"161","author":"Besselink","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.hpb.2026.06.021_bib30","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jamcollsurg.2020.01.028","article-title":"Extended experience with a dynamic, data-driven selective drain management protocol in pancreaticoduodenectomy: progressive risk stratification for better practice","volume":"230","author":"Trudeau","year":"2020","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib31","doi-asserted-by":"crossref","first-page":"e665","DOI":"10.1097\/SLA.0000000000005316","article-title":"Coronary artery stent for securing high-risk pancreatico-jejunal anastomosis after pancreatoduodenectomy: a pilot series","volume":"275","author":"Huscher","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib32","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.surg.2016.11.021","article-title":"Pancreatic anastomosis after pancreatoduodenectomy: a position statement by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"161","author":"Shrikhande","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.06.021_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12893-021-01074-w","article-title":"The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy in patients with FRS >\/= 4: a retrospective cohort study","volume":"21","author":"Jiang","year":"2021","journal-title":"BMC Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib34","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/bjs.10160","article-title":"Randomized multicentre trial comparing external and internal pancreatic stenting during pancreaticoduodenectomy","volume":"103","author":"Jang","year":"2016","journal-title":"Br J Surg"},{"key":"10.1016\/j.hpb.2026.06.021_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.suronc.2025.102239","article-title":"Technical tips on pancreatojejunostomy and gastrojejunostomy during robotic pancreatoduodenectomy with comparison between the internal and external stent for pancreatojejunostomy","volume":"61","author":"Ito","year":"2025","journal-title":"Surg Oncol"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X26006945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X26006945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:21:59Z","timestamp":1791501719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X26006945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1365182X26006945"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2026.06.021","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trans-anastomotic stent does not impact the predictive value of drain fluid amylase after pancreatoduodenectomy","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2026.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.","name":"copyright","label":"Copyright"}]}}