{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T16:25:37Z","timestamp":1794068737479,"version":"4.8.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.hpb.2026.08.010","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:44:35Z","timestamp":1787438675000},"page":"1485-1497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of severe postoperative complications after curative-intent resection for perihilar cholangiocarcinoma: an international multi-institutional analysis"],"prefix":"10.1016","volume":"28","author":[{"given":"Yutaka","family":"Endo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2899-4030","authenticated-orcid":false,"given":"Kizuki","family":"Yuza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8377-0263","authenticated-orcid":false,"given":"Odysseas","family":"Chatzipanagiotou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5023-3561","authenticated-orcid":false,"given":"Selamawit","family":"Woldesenbet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-563X","authenticated-orcid":false,"given":"Andrea","family":"Ruzzenente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo P.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas G.","family":"Koerkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pulitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Aucejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-5937","authenticated-orcid":false,"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hpb.2026.08.010_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jhbp.12129","article-title":"Annual report of Japanese biliary tract cancer registry from 2021: focus on the rate of R0 resection, postoperative complications, and site of lymph node metastasis","volume":"32","author":"Kato","year":"2025","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hpb.2026.08.010_bib2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/HEP.0000000000000554","article-title":"Predicting futility of upfront surgery in perihilar cholangiocarcinoma: machine learning analytics model to optimize treatment allocation","volume":"79","author":"Ratti","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.hpb.2026.08.010_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21037\/hbsn-24-385","article-title":"Predictive model for very early recurrence of patients with perihilar cholangiocarcinoma: a machine learning approach","volume":"14","author":"Kawashima","year":"2025","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.hpb.2026.08.010_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/ags3.12644","article-title":"Prognostic impact of preoperative skeletal muscle change from diagnosis to surgery in patients with perihilar cholangiocarcinoma","volume":"7","author":"Hayashi","year":"2023","journal-title":"Ann Gastroenterol Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/SLA.0000000000005162","article-title":"Early prediction of a serious postoperative course in perihilar cholangiocarcinoma: trajectory analysis of the comprehensive complication index","volume":"277","author":"Kawakatsu","year":"2023","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/SLA.0b013e3182708b57","article-title":"Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections","volume":"258","author":"Nagino","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib7","doi-asserted-by":"crossref","first-page":"9597","DOI":"10.1245\/s10434-025-18137-4","article-title":"Operative and oncological outcomes of vascular resection and reconstruction for perihilar cholangiocarcinoma","volume":"32","author":"Poletto","year":"2025","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"10.1016\/j.hpb.2026.08.010_bib8","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1007\/s00268-023-06974-x","article-title":"Predictors and prognostic significance of postoperative complications for patients with intrahepatic cholangiocarcinoma","volume":"47","author":"Endo","year":"2023","journal-title":"World J Surg"},{"issue":"8","key":"10.1016\/j.hpb.2026.08.010_bib9","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.hpb.2024.04.013","article-title":"Prognostic significance of postoperative complications for patients with hepatocellular carcinoma relative to alpha-feto protein and tumor burden score","volume":"26","author":"Endo","year":"2024","journal-title":"HPB"},{"key":"10.1016\/j.hpb.2026.08.010_bib10","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1245\/s10434-008-9890-5","article-title":"Perioperative use of beta-blockers and COX-2 inhibitors May improve immune competence and reduce the risk of tumor metastasis","volume":"15","author":"Benish","year":"2008","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"10.1016\/j.hpb.2026.08.010_bib11","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1245\/s10434-023-13825-5","article-title":"Impact of surgical margin width on prognosis following resection of hepatocellular carcinoma varies on the basis of preoperative alpha-feto protein and tumor burden score","volume":"30","author":"Endo","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2026.08.010_bib12","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1245\/s10434-022-12803-7","article-title":"Higher tumor burden status dictates the impact of surgical margin status on overall survival in patients undergoing resection of intrahepatic cholangiocarcinoma","volume":"30","author":"Endo","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2026.08.010_bib13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jso.24125","article-title":"Postoperative complications and overall survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma","volume":"113","author":"Pugalenthi","year":"2016","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.hpb.2026.08.010_bib14","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/SLA.0b013e31816c405f","article-title":"Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer","volume":"247","author":"Ito","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/SLA.0000000000004465","article-title":"Mild prognostic impact of postoperative complications on long-term survival of perihilar cholangiocarcinoma","volume":"276","author":"Kawakatsu","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.hpb.2024.11.007","article-title":"Lymphadenectomy for perihilar cholangiocarcinoma: therapeutic benefit of lymph node number and station","volume":"27","author":"Kawashima","year":"2025","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.hpb.2026.08.010_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0000000000004808","article-title":"Proposal of a new comprehensive notation for hepatectomy: the \"New World\" terminology","volume":"274","author":"Nagino","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0b013e318296c732","article-title":"The comprehensive complication index: a novel continuous scale to measure surgical morbidity","volume":"258","author":"Slankamenac","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the international study group of liver surgery (ISGLS)","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.08.010_bib20","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.surg.2010.12.002","article-title":"Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the international study group of liver surgery","volume":"149","author":"Koch","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.08.010_bib21","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1007\/s11605-019-04127-x","article-title":"Evaluation of the new American joint committee on cancer staging manual 8th edition for perihilar cholangiocarcinoma","volume":"24","author":"Gaspersz","year":"2020","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R","article-title":"Multiple imputation of missing blood pressure covariates in survival analysis","volume":"18","author":"van Buuren","year":"1999","journal-title":"Stat Med"},{"key":"10.1016\/j.hpb.2026.08.010_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.hbpd.2018.03.016","article-title":"Prognostic value of postoperative complication for early recurrence after curative resection of hepatocellular carcinoma","volume":"17","author":"Amisaki","year":"2018","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.hpb.2026.08.010_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/21681805.2021.1983016","article-title":"Inflammatory response markers and survival prediction in patients with renal cell carcinoma","volume":"56","author":"Mountzias","year":"2022","journal-title":"Scand J Urol"},{"key":"10.1016\/j.hpb.2026.08.010_bib25","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/cncr.29419","article-title":"Impact of complications on long-term survival after resection of intrahepatic cholangiocarcinoma","volume":"121","author":"Spolverato","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.hpb.2026.08.010_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1067\/msy.2000.103498","article-title":"Suppression of cellular immunity by surgical stress","volume":"127","author":"Ogawa","year":"2000","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.08.010_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41523-021-00376-9","article-title":"Inflammatory cytokines and distant recurrence in HER2-negative early breast cancer","volume":"8","author":"Sparano","year":"2022","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.hpb.2026.08.010_bib28","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1245\/s10434-011-2041-4","article-title":"Postoperative complications deteriorate long-term outcome in pancreatic cancer patients","volume":"19","author":"Kamphues","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.hpb.2026.08.010_bib29","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/01.sla.0000094437.68038.a3","article-title":"Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases","volume":"238","author":"Ebata","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jhbp.918","article-title":"Mortality, morbidity, and failure to rescue in hepatopancreatoduodenectomy: an analysis of patients registered in the national clinical database in Japan","volume":"28","author":"Endo","year":"2021","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.hpb.2026.08.010_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/SLA.0000000000003223","article-title":"Benchmarks in pancreatic surgery: a novel tool for unbiased outcome comparisons","volume":"270","author":"Sanchez-Velazquez","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.surg.2023.10.019","article-title":"Postoperative morbidity after simultaneous versus staged resection of synchronous colorectal liver metastases: impact of hepatic tumor burden","volume":"175","author":"Endo","year":"2023","journal-title":"Surgery"},{"key":"10.1016\/j.hpb.2026.08.010_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jamcollsurg.2016.01.060","article-title":"Preoperative cholangitis and future liver remnant volume determine the risk of liver failure in patients undergoing resection for hilar cholangiocarcinoma","volume":"223","author":"Ribero","year":"2016","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jamcollsurg.2016.03.035","article-title":"Postoperative mortality after liver resection for perihilar cholangiocarcinoma: development of a risk score and importance of biliary drainage of the future liver remnant","volume":"223","author":"Wiggers","year":"2016","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib35","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/ags3.12734","article-title":"Essential updates 2021\/2022: update in surgical strategy for perihilar cholangiocarcinoma","volume":"7","author":"Kawano","year":"2023","journal-title":"Ann Gastroenterol Surg"},{"key":"10.1016\/j.hpb.2026.08.010_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00423-024-03251-w","article-title":"Multimodal prehabilitation program in patients with resectable perihilar cholangiocarcinoma: keypoints for an implementation protocol and literature review","volume":"409","author":"Lopez-Lopez","year":"2024","journal-title":"Langenbecks Arch Surg"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X26007331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X26007331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T15:46:29Z","timestamp":1794066389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X26007331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1365182X26007331"],"URL":"https:\/\/doi.org\/10.1016\/j.hpb.2026.08.010","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic impact of severe postoperative complications after curative-intent resection for perihilar cholangiocarcinoma: an international multi-institutional analysis","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hpb.2026.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc.","name":"copyright","label":"Copyright"}]}}