{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:17:57Z","timestamp":1778858277193,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006279","name":"Abbott Cardiovascular - St Paul Tech Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["heartrhythmopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm O2"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.hroo.2021.08.006","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T23:46:57Z","timestamp":1630712817000},"page":"529-536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maximizing detection and optimal characterization of local abnormal ventricular activity in nonischemic cardiomyopathy: LAVAMAX &amp; LAVAFLOW"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-5327","authenticated-orcid":false,"given":"Karl","family":"Magtibay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Mass\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Niri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram B.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Curtis","family":"Deno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumaraswamy","family":"Nanthakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hroo.2021.08.006_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0735-1097(02)02623-2","article-title":"Ablation of electrograms with an isolated, delayed component as treatment of unmappable monomorphic ventricular tachycardias in patients with structural heart disease","volume":"41","author":"Arenal","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib2","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1161\/CIRCULATIONAHA.111.043216","article-title":"Elimination of local abnormal ventricular activities: a new end point for substrate modification in patients with scar-related ventricular tachycardia","volume":"125","author":"Jais","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.hroo.2021.08.006_bib3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/CIRCEP.109.904763","article-title":"The pathophysiologic basis of fractionated and complex electrograms and the impact of recording techniques on their detection and interpretation","volume":"3","author":"De Bakker","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.hlc.2018.10.007","article-title":"Catheter ablation of VT in non-ischaemic cardiomyopathies: endocardial, epicardial, and intramural approaches","volume":"28","author":"Bhaskaran","year":"2019","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.hroo.2021.08.006_bib5","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.jacc.2010.01.041","article-title":"Characterization of the arrhythmogenic substrate in ischemic and non-ischemic cardiomyopathy","volume":"55","author":"Nakahara","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jacep.2018.01.013","article-title":"Targeting the hidden substrate unmasked by right ventricular extrastimulation improves ventricular tachycardia ablation outcome after myocardial infarction","volume":"4","author":"De Riva","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib7","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1161\/CIRCEP.115.003083","article-title":"Decrement evoked potential mapping: basis of a mechanistic strategy for ventricular tachycardia ablation","volume":"8","author":"Jackson","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib8","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jacc.2005.12.062","article-title":"Isolated potentials during sinus rhythm and pace-mapping within scars as guides for ablation of post-infarction ventricular tachycardia","volume":"47","author":"Bogun","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/jce.12565","article-title":"Substrate mapping and ablation for ventricular tachycardia: the LAVA approach","volume":"26","author":"Sacher","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib10","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.jacep.2019.06.004","article-title":"Multisize electrodes for substrate identification in ischemic cardiomyopathy: validation by integration of whole heart histology","volume":"5","author":"Glashan","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib11","first-page":"440","article-title":"A novel multi-electrode catheter for high-density ventricular mapping: electrogram characterization and utility for scar mapping","volume":"22","author":"Barkagan","year":"2020","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2021.08.006_bib12","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.hrthm.2016.07.003","article-title":"Scar voltage threshold determination using ex\u00a0vivo magnetic resonance imaging integration in a porcine infarct model: influence of interelectrode distances and three-dimensional spatial effects of scar","volume":"13","author":"Tung","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2021.08.006_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007158","article-title":"Impact of spacing and orientation on the scar threshold with a high-density grid catheter","volume":"12","author":"Takigawa","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jacep.2019.11.007","article-title":"High-density grid catheter for detailed mapping of sinus rhythm and scar-related ventricular tachycardia: comparison with a linear duodecapolar catheter","volume":"6","author":"Jiang","year":"2020","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10840-019-00625-9","article-title":"Enhanced ventricular tachycardia substrate resolution with a novel omnipolar high-density mapping catheter: the omnimapping study","volume":"58","author":"Proietti","year":"2020","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib16","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1109\/TBME.2016.2589158","article-title":"Orientation independent catheter-based characterization of myocardial activation","volume":"64","author":"Deno","year":"2017","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.hroo.2021.08.006_bib17","first-page":"0780","article-title":"A data acquisition system for real-time activation detection of cardiac electrograms I: hardware","volume":"13","author":"Mass\u00e9","year":"1991","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.hroo.2021.08.006_bib18","first-page":"782","article-title":"A data acquisition system for real-time activation detection of cardiac electrograms II: software","volume":"13","author":"Mass\u00e9","year":"1991","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.hroo.2021.08.006_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004107","article-title":"Resolving myocardial activation with novel omnipolar electrograms","volume":"9","author":"Mass\u00e9","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib20","first-page":"S197","article-title":"Quantifying bipolar bias in atria and guidance to map physiologically relevant low-voltage [abstract]","volume":"17","author":"Deno","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2021.08.006_bib21","first-page":"S606","article-title":"A more definitive method to map arrhythmogenic substrate for VT ablation [abstract]","volume":"17","author":"Mass\u00e9","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2021.08.006_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v031.i10","article-title":"CircStat: a MATLAB toolbox for circular statistics","volume":"31","author":"Berens","year":"2009","journal-title":"J Stat Softw"},{"key":"10.1016\/j.hroo.2021.08.006_bib23","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.hrthm.2015.05.036","article-title":"Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: an international VT ablation center collaborative group study","volume":"12","author":"Tung","year":"2015","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.hroo.2021.08.006_bib24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jacc.2012.03.044","article-title":"Endo-epicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathy","volume":"60","author":"Di Biase","year":"2012","journal-title":"JACC"},{"key":"10.1016\/j.hroo.2021.08.006_bib25","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.jacc.2015.10.026","article-title":"Ablation of stable VTs versus substrate ablation in ischemic cardiomyopathy: the VISTA randomized multicenter trial","volume":"66","author":"Di Biase","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007293","article-title":"Effect of activation wavefront on electrogram characteristics during ventricular tachycardia","volume":"12","author":"Martin","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/CIRCRESAHA.111.260943","article-title":"High-resolution 3-dimensional reconstruction of the infarct border zone: impact of structural remodeling on electrical activation","volume":"111","author":"Rutherford","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.hroo.2021.08.006_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.115.003841","article-title":"High-resolution mapping of ventricular scar: comparison between single and multi-electrode catheters","volume":"9","author":"Tschabrunn","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/jce.12761","article-title":"Impact of electrode type on mapping of scar-related VT","volume":"26","author":"Berte","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib30","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.hrthm.2018.07.020","article-title":"Effect of bipolar electrode orientation on local electrogram properties","volume":"15","author":"Takigawa","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2021.08.006_bib31","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/europace\/euy304","article-title":"Omnipolarity applied to equi-spaced electrode array for ventricular tachycardia substrate mapping","volume":"21","author":"Porta-S\u00e1nchez","year":"2019","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2021.08.006_bib32","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/0735-1097(95)00086-J","article-title":"Endocardial mapping of ventricular tachycardia in the intact human ventricle. III. Evidence of multiuse reentry with spontaneous and induced block in portions of re-entrant path complex","volume":"25","author":"Downar","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2021.08.006_bib33","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.hrthm.2009.08.038","article-title":"Cardiac ripple mapping: a novel three-dimensional visualization method for use with electroanatomic mapping of cardiac arrhythmias","volume":"6","author":"Linton","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2021.08.006_bib34","first-page":"S569","article-title":"Optimization of near-field electrogram components for mapping of scar related ventricular tachycardia substrate: electrogram \u201ctuning\u201d with omnipolar mapping technology [abstract]","volume":"17","author":"Nishimura","year":"2020","journal-title":"Heart Rhythm"}],"container-title":["Heart Rhythm O2"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501821001604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501821001604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:24:55Z","timestamp":1762993495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666501821001604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2666501821001604"],"URL":"https:\/\/doi.org\/10.1016\/j.hroo.2021.08.006","relation":{},"ISSN":["2666-5018"],"issn-type":[{"value":"2666-5018","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maximizing detection and optimal characterization of local abnormal ventricular activity in nonischemic cardiomyopathy: LAVAMAX & LAVAFLOW","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm O2","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hroo.2021.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Heart Rhythm Society. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}