{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T12:10:26Z","timestamp":1742472626135,"version":"3.40.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["heartrhythmopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm O2"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.hroo.2024.12.006","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T17:43:25Z","timestamp":1735062205000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left atrial remodeling and voltage-guided ablation outcome in persistent atrial fibrillation patients over 75 years of age"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-2533","authenticated-orcid":false,"given":"Halim","family":"Marzak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Baldacini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Severac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Fitouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Kanso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Schatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Ohlmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Jesel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hroo.2024.12.006_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/CLEP.S47385","article-title":"Epidemiology of atrial fibrillation: European perspective","volume":"6","author":"Zoni-Berisso","year":"2014","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib2","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.hroo.2024.12.006_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.hrthm.2006.11.011","article-title":"Aging and atrial fibrillation research: where we are and where we should go","volume":"4","author":"Pandit","year":"2007","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2024.12.006_bib4","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2019.0693","article-title":"Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial","volume":"321","author":"Packer","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.hroo.2024.12.006_bib5","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.3390\/jcm11206070","article-title":"Persistent atrial fibrillation in elderly patients: limited efficacity of pulmonary vein isolation","volume":"11","author":"Boehmer","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.hroo.2024.12.006_bib6","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.3390\/jcm11154468","article-title":"Do elderly patients with atrial fibrillation have comparable ablation outcomes compared to younger ones? Evidence from pooled clinical studies","volume":"11","author":"Li","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.hroo.2024.12.006_bib7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/europace\/eut265","article-title":"Long-term results of pulmonary vein antrum isolation in patients with atrial fibrillation: an analysis in regards to substrates and pulmonary vein reconnections","volume":"16","author":"Yamaguchi","year":"2014","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2024.12.006_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10840-018-0471-7","article-title":"Predictors of low voltage areas in persistent atrial fibrillation: is it really a matter of time?","volume":"57","author":"Ammar-Busch","year":"2020","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib9","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/europace\/eux082","article-title":"Prevalence and predictors of low voltage zones in the left atrium in patients with atrial fibrillation","volume":"20","author":"Huo","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2024.12.006_bib10","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/clc.24031","article-title":"Safety and efficacy of ablation index-guided atrial fibrillation ablation in octogenarians","volume":"46","author":"Okamatsu","year":"2023","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib11","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/europace\/eux310","article-title":"Individually tailored vs. standardized substrate modification during radiofrequency catheter ablation for atrial fibrillation: a randomized study","volume":"20","author":"Kircher","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2024.12.006_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/jce.12870","article-title":"Box isolation of fibrotic areas (BIFA): a patient-tailored substrate modification approach for ablation of atrial fibrillation","volume":"27","author":"Kottkamp","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib13","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200141","article-title":"Low-voltage myocardium-guided ablation trial of persistent atrial fibrillation","volume":"1","author":"Huo","year":"2022","journal-title":"NEJM Evid"},{"key":"10.1016\/j.hroo.2024.12.006_bib14","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/europace\/euac089","article-title":"Low-voltage area substrate modification for atrial fibrillation ablation: a systematic review and meta-analysis of clinical trials","volume":"24","author":"Junarta","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2024.12.006_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivar Behav Res"},{"key":"10.1016\/j.hroo.2024.12.006_bib16","first-page":"215","article-title":"A weighting analogue to pair matching in propensity score analysis","volume":"9","author":"Li","year":"2013","journal-title":"Int J Biostat"},{"key":"10.1016\/j.hroo.2024.12.006_bib17","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/sim.6607","article-title":"Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies","volume":"34","author":"Austin","year":"2015","journal-title":"Stat Med"},{"key":"10.1016\/j.hroo.2024.12.006_bib18","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1161\/CIRCULATIONAHA.108.811877","article-title":"Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation","volume":"119","author":"Oakes","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.hroo.2024.12.006_bib19","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.hrthm.2010.06.030","article-title":"Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: implications for disease progression and response to catheter ablation","volume":"7","author":"Mahnkopf","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2024.12.006_bib20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jamacardio.2023.1749","article-title":"Circumferential pulmonary vein isolation with vs without additional low-voltage-area ablation in older patients with paroxysmal atrial fibrillation: a randomized clinical trial","volume":"8","author":"Chen","year":"2023","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00392-018-1336-x","article-title":"Safety and efficacy of cryoballoon ablation for the treatment of atrial fibrillation in elderly patients","volume":"108","author":"Abdin","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/CIRCEP.111.965541","article-title":"Left atrial wall stress distribution and its relationship to electrophysiologic remodeling in persistent atrial fibrillation","volume":"5","author":"Hunter","year":"2012","journal-title":"Circ Arrhythm Electrophyiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijcard.2018.07.076","article-title":"Low voltage areas in paroxysmal atrial fibrillation: the prevalence, risk factors and impact on the effectiveness of catheter ablation","volume":"269","author":"Wang","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib24","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/jce.13278","article-title":"Catheter ablation of atrial fibrillation with box isolation of fibrotic areas: lessons on fibrosis distribution and extent, clinical characteristics, and their impact on long-term outcome","volume":"28","author":"Schreiber","year":"2017","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib25","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1185\/030079905X65475","article-title":"Economic burden and co-morbidities of atrial fibrillation in a privately insured population","volume":"21","author":"Wu","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.hroo.2024.12.006_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/europace\/euq325","article-title":"Predictors of costs related to cardiovascular disease among patients with atrial fibrillation in five European countries","volume":"13","author":"Holstenson","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2024.12.006_bib27","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0002-9149(00)01251-0","article-title":"Acute electrophysiologic effect of estradiol 17\u03b2 in menopausal women","volume":"86","author":"Rosano","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib28","doi-asserted-by":"crossref","first-page":"53714","DOI":"10.18632\/oncotarget.16342","article-title":"Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.hroo.2024.12.006_bib29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1540-8167.2010.01993.x","article-title":"Total and interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation","volume":"22","author":"Shin","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib30","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1253\/circj.CJ-18-1277","article-title":"Impact of renal dysfunction on left atrial low-voltage areas in patients with atrial fibrillation","volume":"83","author":"Matsuda","year":"2019","journal-title":"Circ J"},{"key":"10.1016\/j.hroo.2024.12.006_bib31","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.hrthm.2012.08.019","article-title":"Establishment of a model of atrial fibrillation associated with chronic kidney disease in rats and the role of oxidative stress","volume":"9","author":"Fukunaga","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2024.12.006_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027795","article-title":"Characterization of atrial substrate to predict the success of pulmonary vein isolation: the prospective, multicenter MASH-AF II (Multipolar Atrial Substrate High Density Mapping in Atrial Fibrillation) study","volume":"12","author":"Bergonti","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hroo.2024.12.006_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijcard.2018.07.048","article-title":"Extent and magnitude of low-voltage areas assessed by ultra-high-density electroanatomical mapping correlate with left atrial function","volume":"272","author":"Hohendanner","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jce.12849","article-title":"The impact of age on 5-year outcomes after\u00a0atrial fibrillation catheter ablation","volume":"27","author":"Bunch","year":"2016","journal-title":"Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2024.12.006_bib35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/europace\/euv229","article-title":"Ablation of atrial fibrillation in patients \u226575 years: long-term clinical outcome and safety","volume":"18","author":"Metzner","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2024.12.006_bib36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ipej.2021.11.006","article-title":"Safety and efficacity of cryoballoon versus radiofrequency ablation for atrial fibrillation in elderly patients: a real-world evidence","volume":"22","author":"Akhtar","year":"2022","journal-title":"Indian Pacing Electrophysiol J"},{"key":"10.1016\/j.hroo.2024.12.006_bib37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/clc.23335","article-title":"Comparing between second-generation cryoballoon vs open-irrigated radiofrequency ablation in elderly patients: acute and long-term outcomes","volume":"43","author":"Chen","year":"2020","journal-title":"Clin Cardiol"}],"container-title":["Heart Rhythm O2"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501824004434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501824004434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T11:21:44Z","timestamp":1742469704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666501824004434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2666501824004434"],"URL":"https:\/\/doi.org\/10.1016\/j.hroo.2024.12.006","relation":{},"ISSN":["2666-5018"],"issn-type":[{"type":"print","value":"2666-5018"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left atrial remodeling and voltage-guided ablation outcome in persistent atrial fibrillation patients over 75 years of age","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm O2","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hroo.2024.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Heart Rhythm Society. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}