{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:47:47Z","timestamp":1768834067138,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Netherlands Heart Foundation","doi-asserted-by":"publisher","award":["STT-vision 2020-B010"],"award-info":[{"award-number":["STT-vision 2020-B010"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023794","name":"Genetic Heart Muscle Disease Foundation PLN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["heartrhythmopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm O2"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.hroo.2025.07.105","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T15:13:27Z","timestamp":1754666007000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["CineECG detects abnormal electrical activity in the 12-lead ECG of preclinical plakophilin-2 variant carriers"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0444-9994","authenticated-orcid":false,"given":"Iris","family":"van der Schaaf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Kloosterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton P.M.","family":"Gorgels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneline S.J.M.","family":"te Riele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"van Dam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Loh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hroo.2025.07.105_bib1","doi-asserted-by":"crossref","first-page":"105128","DOI":"10.1016\/j.compbiomed.2021.105128","article-title":"CineECG: a novel method to image the average activation sequence in the heart from the 12-lead ECG","volume":"141","author":"Boonstra","year":"2022","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.hroo.2025.07.105_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jelectrocard.2022.10.013","article-title":"ECG-based techniques to enhance clinical practice in cardiac genetic disease management","volume":"76","author":"Boonstra","year":"2023","journal-title":"J Electrocardiol"},{"issue":"suppl 1","key":"10.1016\/j.hroo.2025.07.105_bib3","doi-asserted-by":"crossref","first-page":"i80","DOI":"10.1093\/europace\/euaa396","article-title":"Novel CineECG enables anatomical 3D localization and classification of bundle branch blocks","volume":"23","author":"Boonstra","year":"2021","journal-title":"EP Europace"},{"key":"10.1016\/j.hroo.2025.07.105_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jelectrocard.2023.01.004","article-title":"CineECG illustrating the ventricular activation sequence in progressive AV-junctional conduction block","volume":"78","author":"van der Schaaf","year":"2023","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jelectrocard.2024.01.007","article-title":"CineECG for visualization of changes in ventricular electrical activity during ischemia","volume":"83","author":"van der Schaaf","year":"2024","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008524","article-title":"Novel CineECG derived from standard 12-lead ECG enables right ventricle outflow tract localization of electrical substrate in patients with Brugada syndrome","volume":"13","author":"van Dam","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad116","article-title":"CineECG analysis provides new insights into Familial ST-segment Depression Syndrome","volume":"25","author":"Frosted","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2025.07.105_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jacep.2021.12.002","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hroo.2025.07.105_bib10","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","article-title":"HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy","volume":"16","author":"Towbin","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2025.07.105_bib11","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/CIRCRESAHA.117.309345","article-title":"Arrhythmogenic cardiomyopathy","volume":"121","author":"Corrado","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.hroo.2025.07.105_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.hroo.2025.07.105_bib13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jcmg.2018.01.012","article-title":"The prognostic value of right ventricular deformation imaging in early arrhythmogenic right ventricular cardiomyopathy","volume":"12","author":"Mast","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.hroo.2025.07.105_bib14","series-title":"Comprehensive Electrocardiology","first-page":"485","article-title":"The normal electrocardiogram and vectorcardiogram","volume":"1","author":"Macfarlane","year":"2010"},{"key":"10.1016\/j.hroo.2025.07.105_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tcm.2020.07.006","article-title":"Arrhythmogenic cardiomyopathy: an in-depth look at molecular mechanisms and clinical correlates","volume":"31","author":"Costa","year":"2021","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.hroo.2025.07.105_bib17","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1540-8167.2006.00367.x","article-title":"Continuous and discontinuous propagation in heart muscle","volume":"17","author":"De Bakker","year":"2006","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib18","doi-asserted-by":"crossref","first-page":"131289","DOI":"10.1016\/j.ijcard.2023.131289","article-title":"Electroanatomical voltage mapping with contact force sensing for diagnosis of arrhythmogenic right ventricular cardiomyopathy","volume":"392","author":"Saguner","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad197","article-title":"Body surface potential mapping detects early disease onset in plakophilin-2 -pathogenic variant carriers","volume":"25","author":"Kloosterman","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2025.07.105_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0280111","article-title":"Epicardial conduction abnormalities in patients with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) and mutation positive healthy family members\u2013a study using electrocardiographic imaging","volume":"18","author":"Kommata","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.hroo.2025.07.105_bib22","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/pace.14295","article-title":"QRS dispersion detected in ARVC patients and healthy gene carriers using 252-leads body surface mapping: an explorative study of a potential diagnostic tool for arrhythmogenic right ventricular cardiomyopathy","volume":"44","author":"Kommata","year":"2021","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/pace.14456","article-title":"Repolarization abnormalities unmasked with a 252-lead BSM system in patients with ARVC and healthy gene carriers","volume":"45","author":"Kommata","year":"2022","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hroo.2025.07.105_bib24","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s11886-022-01777-3","article-title":"Genotype\u2013phenotype correlates in arrhythmogenic cardiomyopathies","volume":"24","author":"Murray","year":"2022","journal-title":"Curr Cardiol Rep"}],"container-title":["Heart Rhythm O2"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501825003721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501825003721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T01:44:35Z","timestamp":1757123075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666501825003721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":22,"alternative-id":["S2666501825003721"],"URL":"https:\/\/doi.org\/10.1016\/j.hroo.2025.07.105","relation":{},"ISSN":["2666-5018"],"issn-type":[{"value":"2666-5018","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CineECG detects abnormal electrical activity in the 12-lead ECG of preclinical plakophilin-2 variant carriers","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm O2","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hroo.2025.07.105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Heart Rhythm Society. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}