{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:30:33Z","timestamp":1790224233822,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmopen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm O2"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.hroo.2026.02.027","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:28:00Z","timestamp":1773131280000},"page":"1250-1256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravenous vernakalant for acute termination of recent-onset atrial fibrillation in the emergency department"],"prefix":"10.1016","volume":"7","author":[{"given":"Karin","family":"Heller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Viskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophir","family":"Freund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shir","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Zandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moaath","family":"Slieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zeltser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Viskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-1162","authenticated-orcid":false,"given":"Ehud","family":"Chorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hroo.2026.02.027_bib1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hroo.2026.02.027_bib2","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/eurheartj\/ehp235","article-title":"Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference \u2018research perspectives in AF\u2019","volume":"30","author":"Kirchhof","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hroo.2026.02.027_bib3","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/eurheartj\/ehu028","article-title":"Early management of atrial fibrillation to prevent cardiovascular complications","volume":"35","author":"Nattel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hroo.2026.02.027_bib4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.121.056323","article-title":"Early rhythm control therapy in patients with atrial fibrillation and heart failure","volume":"144","author":"Rillig","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.hroo.2026.02.027_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hroo.2026.02.027_bib6","first-page":"1371","article-title":"2018 Focused update of the Canadian Cardiovascular Society guidelines for the management of atrial fibrillation","volume":"34","author":"Andrade","year":"2018","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.hroo.2026.02.027_bib7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrd3323","article-title":"Vernakalant","volume":"9","author":"Dobrev","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.hroo.2026.02.027_bib8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/europace\/euz175","article-title":"Vernakalant for cardioversion of recent-onset atrial fibrillation: a systematic review and meta-analysis","volume":"21","author":"McIntyre","year":"2019","journal-title":"Europace"},{"key":"10.1016\/j.hroo.2026.02.027_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1573403X10666140513103709","article-title":"The vernakalant story: how did it come to approval in Europe and what is the delay in the U.S.A?","volume":"10","author":"Camm","year":"2014","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.hroo.2026.02.027_bib10","doi-asserted-by":"crossref","first-page":"e500","DOI":"10.1016\/j.hrthm.2025.03.1997","article-title":"The modernized classification of cardiac antiarrhythmic drugs: its application to clinical practice","volume":"22","author":"Lei","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2026.02.027_bib11","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/CIRCULATIONAHA.107.723866","article-title":"Vernakalant hydrochloride for rapid conversion of atrial fibrillation: a phase 3, randomized, placebo-controlled trial","volume":"117","author":"Roy","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.hroo.2026.02.027_bib12","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/CIRCEP.109.870204","article-title":"Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial","volume":"2","author":"Kowey","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hroo.2026.02.027_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12872-016-0289-0","article-title":"Safety and efficacy of vernakalant for the conversion of atrial fibrillation to sinus rhythm; a phase 3b randomized controlled trial","volume":"16","author":"Beatch","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.hroo.2026.02.027_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jacc.2010.07.046","article-title":"A randomized active-controlled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation","volume":"57","author":"Camm","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2026.02.027_bib15","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.jacc.2004.09.021","article-title":"A randomized, controlled trial of RSD1235, a novel anti-arrhythmic agent, in the treatment of recent onset atrial fibrillation","volume":"44","author":"Roy","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hroo.2026.02.027_bib16","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.amjcard.2010.06.054","article-title":"Usefulness of vernakalant hydrochloride injection for rapid conversion of atrial fibrillation","volume":"106","author":"Pratt","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hroo.2026.02.027_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.ahj.2010.02.035","article-title":"A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm","volume":"159","author":"Stiell","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.hroo.2026.02.027_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/FJC.0000000000000445","article-title":"Efficacy and safety of vernakalant for cardioversion of recent-onset atrial fibrillation in the Asia-Pacific region: a phase 3 randomized controlled trial","volume":"69","author":"Beatch","year":"2017","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.hroo.2026.02.027_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2025-085632","article-title":"Vernakalant versus procainamide for rapid cardioversion of patients with acute atrial fibrillation (RAFF4): randomised clinical trial","volume":"391","author":"Stiell","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.hroo.2026.02.027_bib20","article-title":"Vernakalant and electrical cardioversion for AF - Safe and effective","volume":"24","author":"Simon","year":"2019","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.hroo.2026.02.027_bib21","first-page":"114","article-title":"Intravenous vernakalant in comparison with intravenous flecainide in the cardioversion of recent-onset atrial fibrillation","volume":"8","author":"Pohjant\u00e4hti-Maaroos","year":"2019","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.hroo.2026.02.027_bib22","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hroo.2026.02.027_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10557-020-07103-9","article-title":"Vernakalant for rapid cardioversion of recent-onset atrial fibrillation: results from the SPECTRUM study","volume":"35","author":"L\u00e9vy","year":"2021","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.hroo.2026.02.027_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12873-025-01280-2","article-title":"Real-world experience with vernakalant in the urgent management of atrial fibrillation: results from the VERITA study","volume":"25","author":"Dominijanni","year":"2025","journal-title":"BMC Emerg Med"},{"key":"10.1016\/j.hroo.2026.02.027_bib25","first-page":"397","article-title":"[Vernakalant in hospital emergency practice: safety and effectiveness]","volume":"29","author":"Carbajosa Dalmau","year":"2017","journal-title":"Emergencias"},{"key":"10.1016\/j.hroo.2026.02.027_bib26","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1016\/j.hrthm.2025.05.051","article-title":"Inflammation and risk of cardiovascular outcomes in patients with atrial fibrillation and flutter: a nationwide registry study","volume":"23","author":"Langhoff","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hroo.2026.02.027_bib27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJMcp2023658","article-title":"Atrial fibrillation","volume":"384","author":"Michaud","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hroo.2026.02.027_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ahj.2016.10.018","article-title":"Cardioversion and subsequent quality of life and natural history of atrial fibrillation","volume":"185","author":"Pokorney","year":"2017","journal-title":"Am Heart J"}],"container-title":["Heart Rhythm O2"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501826001042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666501826001042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:59:00Z","timestamp":1784537940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666501826001042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2666501826001042"],"URL":"https:\/\/doi.org\/10.1016\/j.hroo.2026.02.027","relation":{},"ISSN":["2666-5018"],"issn-type":[{"value":"2666-5018","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous vernakalant for acute termination of recent-onset atrial fibrillation in the emergency department","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm O2","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hroo.2026.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Heart Rhythm Society. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}