{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:43:19Z","timestamp":1783471399265,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.hrthm.2004.03.061","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T16:16:34Z","timestamp":1086970594000},"page":"210-217","source":"Crossref","is-referenced-by-count":145,"title":["Role of sodium and calcium channel block in unmasking the Brugada syndrome"],"prefix":"10.1016","volume":"1","author":[{"given":"Jeffrey M.","family":"Fish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Antzelevitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2004.03.061_BIB1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0735-1097(02)01962-9","article-title":"Genotype-phenotype relationship in Brugada syndrome","volume":"40","author":"Smits","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/01.CIR.101.5.510","article-title":"Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts","volume":"101","author":"Brugada","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB4","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1161\/01.CIR.102.20.2509","article-title":"Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome","volume":"102","author":"Priori","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB5","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0735-1097(95)00613-3","article-title":"Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome","volume":"27","author":"Miyazaki","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB6","doi-asserted-by":"crossref","first-page":"K40","DOI":"10.1016\/S0002-9149(00)01300-X","article-title":"Sudden death in high-risk family members","volume":"86","author":"Brugada","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB7","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1161\/01.CIR.100.15.1660","article-title":"Cellular basis for the Brugada Syndrome and other mechanisms of arrhythmogenesis associated with ST segment elevation","volume":"100","author":"Yan","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1046\/j.1540-8167.2001.00268.x","article-title":"The Brugada syndrome","volume":"12","author":"Antzelevitch","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"Suppl","key":"10.1016\/j.hrthm.2004.03.061_BIB9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1054\/jelc.2000.20321","article-title":"Cellular and ionic mechanisms responsible for the Brugada syndrome","volume":"33","author":"Antzelevitch","year":"2000","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB10","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00005344-199511000-00013","article-title":"Terfenadine blocks time-dependent Ca2+, Na+, and K+ channels in guinea pig ventricular myocytes","volume":"26","author":"Ming","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00005344-199903000-00023","article-title":"Terfenadine block of sodium current in canine atrial myocytes","volume":"33","author":"Lu","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/01.RES.81.2.202","article-title":"Inhibition of L-type Ca2+ channel current in rat ventricular myocytes by terfenadine","volume":"81","author":"Liu","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB13","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1161\/01.CIR.98.18.1928","article-title":"Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome","volume":"98","author":"Yan","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB14","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1161\/01.CIR.98.21.2314","article-title":"Cellular basis for the electrocardiographic features of the LQT1 form of the long QT syndrome","volume":"98","author":"Shimizu","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB15","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.96.6.2038","article-title":"Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing Torsade de Pointes in LQT2 and LQT3 models of the long-QT syndrome","volume":"96","author":"Shimizu","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB16","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1161\/01.CIR.98.18.1921","article-title":"Characteristics and distribution of M cells in arterially-perfused canine left ventricular wedge preparations","volume":"98","author":"Yan","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB17","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1046\/j.1540-8167.2001.01369.x","article-title":"Cellular basis for complex T waves and arrhythmic activity following combined I(Kr) and I(Ks) block","volume":"12","author":"Emori","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB18","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1046\/j.1540-8167.2000.01320.x","article-title":"Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome","volume":"11","author":"Shimizu","year":"2000","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.RES.67.3.615","article-title":"Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium","volume":"67","author":"Litovsky","year":"1990","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB20","series-title":"Handbook of Physiology. The Heart","first-page":"654","article-title":"Electrical heterogeneity in the heart","author":"Antzelevitch","year":"2001"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/01.RES.69.2.277","article-title":"Sodium channel blockade produces opposite electrophysiologic effects in canine ventricular epicardium and endocardium","volume":"69","author":"Krishnan","year":"1991","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB22","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/01.CIR.87.2.562","article-title":"Flecainide-induced arrhythmia in canine ventricular epicardium","volume":"87","author":"Krishnan","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1046\/j.1540-8167.2001.00268.x","article-title":"The Brugada syndrome","volume":"12","author":"Antzelevitch","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB24","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/S0735-1097(02)01887-9","article-title":"Late potentials and the Brugada syndrome","volume":"39","author":"Antzelevitch","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB25","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1046\/j.1540-8167.2002.00816.x","article-title":"Spontaneous T wave alternans and premature ventricular contractions during febrile illness in a patient with Brugada syndrome","volume":"13","author":"Morita","year":"2002","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1046\/j.1540-8167.2002.00837.x","article-title":"Pilsicanide-induced marked T wave alternans and ventricular fibrillation in a patient with Brugada syndrome","volume":"13","author":"Takagi","year":"2002","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB27","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1046\/j.1460-9592.2003.00288.x","article-title":"Intravenous administration of class I antiarrhythmic drug induced T wave alternans in an asymptomatic Brugada syndrome patient","volume":"26","author":"Ohkubo","year":"2003","journal-title":"PACE"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB28","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1540-8167.1999.tb00183.x","article-title":"Effects of electrophysiologic-guided therapy with Class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome","volume":"10","author":"Belhassen","year":"1999","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB29","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1046\/j.1460-9592.2001.01420.x","article-title":"Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome","volume":"24","author":"Alings","year":"2001","journal-title":"PACE"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB30","first-page":"181","article-title":"Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine","volume":"47","author":"Crumb","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB31","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.CIR.94.4.817","article-title":"HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine","volume":"94","author":"Roy","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.76.1.110","article-title":"Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine","volume":"76","author":"Salata","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB33","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1046\/j.1540-8167.2001.01192.x","article-title":"Asymptomatic Brugada syndrome case unmasked during dimenhydrinate infusion","volume":"12","author":"Pastor","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2004.03.061_BIB34","first-page":"863","article-title":"Antiarrhythmic actions of antihistamines","volume":"2","author":"Giotti","year":"1976","journal-title":"Pharmacol Ther [B]"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752710400089X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752710400089X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T23:21:54Z","timestamp":1549495314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154752710400089X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S154752710400089X"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2004.03.061","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}