{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:45:45Z","timestamp":1790883945627,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["K23HL069972"],"award-info":[{"award-number":["K23HL069972"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.hrthm.2005.11.008","type":"journal-article","created":{"date-parts":[[2006,1,28]],"date-time":"2006-01-28T07:10:36Z","timestamp":1138432236000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":194,"title":["Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions"],"prefix":"10.1016","volume":"3","author":[{"given":"Sunny S.","family":"Po","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Scherlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Yamanashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Lazzara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren M.","family":"Jackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2005.11.008_bib1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/01.CIR.95.3.572","article-title":"A focal source of atrial fibrillation treated by discrete radiofrequency ablation","volume":"95","author":"Jais","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Haissaguerre","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2005.11.008_bib3","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/01.CIR.100.18.1879","article-title":"Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins. Electrophysiological characteristic, pharmacological responses and effects of radiofrequency ablation","volume":"100","author":"Chen","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib4","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1161\/01.CIR.101.12.1409","article-title":"Electrophysiological end point for catheter ablation of atrial fibrillation initiated from multiple pulmonary venous foci","volume":"101","author":"Haissaguerre","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib5","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/hc0902.104712","article-title":"Pulmonary vein isolation for paroxysmal and persistent atrial fibrillation","volume":"105","author":"Oral","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib6","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.CIR.0000027821.55835.00","article-title":"Segmental ostial ablation to isolate the pulmonary veins during atrial fibrillation. Feasibility and mechanistic insights","volume":"106","author":"Oral","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib7","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1161\/01.CIR.0000070541.83326.15","article-title":"Phase-array intracardiac echocardiography monitoring during pulmonary vein isolation in patients with atrial fibrillation","volume":"107","author":"Marrouche","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib8","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1161\/01.CIR.102.21.2619","article-title":"Circumferential radiofrequency ablation of pulmonary vein ostia. A new anatomic approach for curing atrial fibrillation","volume":"102","author":"Pappone","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib9","series-title":"Neurocardiology","first-page":"95","article-title":"Structure and function of mammalian intrinsic cardiac neurons","author":"Ardell","year":"1994"},{"key":"10.1016\/j.hrthm.2005.11.008_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L","article-title":"Gross and microscopic anatomy of the human intrinsic cardiac nervous system","volume":"247","author":"Armour","year":"1997","journal-title":"Anat Rec"},{"key":"10.1016\/j.hrthm.2005.11.008_bib11","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.jacc.2005.01.057","article-title":"Autonomically induced conversion of pulmonary vein focal firing into atrial fibrillation","volume":"45","author":"Scherlag","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2005.11.008_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10840-005-2492-2","article-title":"Electrical stimulation to identify neural elements on the heart","volume":"13","author":"Scherlag","year":"2005","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2005.11.008_bib13","article-title":"Limiting the number and extent of radiofrequency applications to terminate atrial fibrillation and subsequently prevent its inducibility (abstr)","volume":"1","author":"Platt","year":"2004","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2005.11.008_bib14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.hrthm.2005.02.012","article-title":"Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation","volume":"2","author":"Patterson","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2005.11.008_bib15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jacc.2003.09.030","article-title":"Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs","volume":"43","author":"Sharifov","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2005.11.008_bib16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/01.RES.32.3.393","article-title":"Selective in situ parasympathetic control of the canine sinoatrial and atrioventricular nodes","volume":"32","author":"Lazzara","year":"1973","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2005.11.008_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-1838(87)90077-4","article-title":"Vagal postganglionic innervation of the canine sinoatrial node","volume":"20","author":"Randall","year":"1987","journal-title":"J Auton Nerv Syst"},{"key":"10.1016\/j.hrthm.2005.11.008_bib18","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.CIR.92.7.1954","article-title":"Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats","volume":"92","author":"Wijffels","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib19","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.CIR.101.22.2631","article-title":"Effects of experimental heart failure on atrial cellular and ionic electrophysiology","volume":"101","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib20","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/hc4601.099402","article-title":"Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure","volume":"104","author":"Li","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib21","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.CIR.0000080327.32573.7C","article-title":"Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction","volume":"108","author":"Miyauchi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.CIR.0000112641.16340.C7","article-title":"Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation","volume":"109","author":"Pappone","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib23","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.jacc.2003.12.054","article-title":"A new approach for catheter ablation of atrial fibrillation","volume":"43","author":"Nademanee","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2005.11.008_bib24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/CIRCULATIONAHA.104.517011","article-title":"Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans","volume":"112","author":"Sanders","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2005.11.008_bib25","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1046\/j.1540-8167.2003.03136.x","article-title":"Rotors and spiral waves in atrial fibrillation","volume":"14","author":"Jalife","year":"2003","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2005.11.008_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0008-6363(02)00223-7","article-title":"Mother rotors and fibrillatory conduction","volume":"54","author":"Jalife","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2005.11.008_bib27","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.jacc.2005.02.070","article-title":"Rapid and stable reentry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation","volume":"45","author":"Po","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2005.11.008_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0079-6107(03)00013-0","article-title":"Mechano-electrical feedback underlying arrhythmias","volume":"82","author":"Franz","year":"2003","journal-title":"Prog Biophys Mol Biol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527105023428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527105023428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:36:48Z","timestamp":1761547008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527105023428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S1547527105023428"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2005.11.008","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2005.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}