{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:41:49Z","timestamp":1791283309127,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.hrthm.2009.02.005","type":"journal-article","created":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T08:57:03Z","timestamp":1234515423000},"page":"776-783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Aldosterone blockade attenuates development of an electrophysiological substrate associated with ventricular tachyarrhythmias in heart failure"],"prefix":"10.1016","volume":"6","author":[{"given":"Bruce S.","family":"Stambler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Laurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil C.","family":"Shroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Hoeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole L.","family":"Martovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2009.02.005_bib1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.RES.0000145047.14691.db","article-title":"What causes sudden death in heart failure?","volume":"95","author":"Tomaselli","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib2","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1161\/CIRCULATIONAHA.106.670109","article-title":"Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death","volume":"115","author":"Pitt","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cardiores.2003.11.037","article-title":"Review of aldosterone and angiotensin II-induced target organ damage and prevention","volume":"61","author":"Struthers","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib4","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/01.RES.85.12.1139","article-title":"Aldosterone upregulates Ca2+ current in adult rat cardiomyocytes","volume":"8512","author":"Benitah","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib5","doi-asserted-by":"crossref","first-page":"H2257","DOI":"10.1152\/ajpheart.01060.2005","article-title":"Aldosterone increases voltage-gated sodium current in ventricular myocytes","volume":"290","author":"Boixel","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2009.02.005_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1469-7793.2001.0151k.x","article-title":"Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes","volume":"537","author":"Benitah","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.hrthm.2009.02.005_bib7","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1161\/CIRCULATIONAHA.104.503706","article-title":"Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias","volume":"111","author":"Ouvrard-Pascaud","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib8","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.CIR.0000138973.55605.38","article-title":"Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction","volume":"110","author":"Perrier","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1254\/jphs.FPJ04025X","article-title":"Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model","volume":"96","author":"Sugiyama","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.hrthm.2009.02.005_bib10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1161\/01.CIR.0000048189.58449.F7","article-title":"Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels","volume":"107","author":"Caballero","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10741-005-2345-1","article-title":"Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis","volume":"10","author":"Sica","year":"2005","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.hrthm.2009.02.005_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1540-8167.2006.00372.x","article-title":"Selective aldosterone blockade suppresses inducibility of sustained atrial tachyarrhythmias in heart failure","volume":"17","author":"Shroff","year":"2006","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2009.02.005_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0160-5402(89)90015-6","article-title":"An improved method to correct the QT interval of the electrocardiogram for changes in heart rate","volume":"22","author":"Van deWater","year":"1989","journal-title":"J Pharmacol Methods"},{"key":"10.1016\/j.hrthm.2009.02.005_bib14","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/01.RES.0000062468.25308.27","article-title":"Transmural heterogeneity of calcium handling in canine","volume":"92","author":"Laurita","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib15","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/01.CIR.0000068342.96569.A1","article-title":"Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation","volume":"107","author":"Saumarez","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0735-1097(95)00612-5","article-title":"Fractionated electrograms in dilated cardiomyopathy: origin and relation to abnormal conduction","volume":"27","author":"de Bakker","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2009.02.005_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.RES.30.5.505","article-title":"Extracellular potentials related to intracellular action potentials in the dog Purkinje system","volume":"30","author":"Spach","year":"1972","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib18","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/0022-0736(88)90061-1","article-title":"A computer model of the electrogram: what causes fractionation?","volume":"21","author":"Lesh","year":"1988","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.hrthm.2009.02.005_bib19","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/01.RES.65.5.1426","article-title":"Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium","volume":"65","author":"Lesh","year":"1989","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1540-8167.2005.30490.x","article-title":"Numerical simulation of paced electrogram fractionation: relating clinical observations to changes in fibrosis and action potential duration","volume":"16","author":"Turner","year":"2005","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2009.02.005_bib21","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1161\/hc5001.100833","article-title":"Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis","volume":"104","author":"Kawara","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.RES.0000144125.61927.1c","article-title":"Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy","volume":"95","author":"Akar","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2009.02.005_bib23","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1161\/CIRCULATIONAHA.106.634626","article-title":"High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction","volume":"114","author":"Beygui","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2009.02.005_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3317\/jraas.2006.005","article-title":"Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart","volume":"7","author":"De Mello","year":"2006","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"10.1016\/j.hrthm.2009.02.005_bib25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0008-6363(03)00251-7","article-title":"Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure","volume":"58","author":"Cittadini","year":"2003","journal-title":"Cardiovasc Res"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527109001301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527109001301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:41:30Z","timestamp":1761547290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527109001301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1547527109001301"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2009.02.005","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aldosterone blockade attenuates development of an electrophysiological substrate associated with ventricular tachyarrhythmias in heart failure","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2009.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}