{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:50:42Z","timestamp":1761547842155,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011125","name":"School of Medicine and Dentistry, University of Rochester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.hrthm.2012.11.007","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T18:30:46Z","timestamp":1353349846000},"page":"354-360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT"],"prefix":"10.1016","volume":"10","author":[{"given":"Valentina","family":"Kutyifa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Bourgoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Catherine","family":"Pouleur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Knappe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Merkely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2012.11.007_bib1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1056\/NEJM200103223441202","article-title":"Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay","volume":"344","author":"Cazeau","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib2","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib3","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1001\/jama.289.20.2685","article-title":"Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD trial","volume":"289","author":"Young","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2012.11.007_bib4","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib5","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib6","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib7","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.jacc.2010.05.055","article-title":"Cardiac resynchronization therapy in asymptomatic or mildly symptomatic heart failure patients in relation to etiology: results from the REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction) study","volume":"56","author":"Linde","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib8","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Cardiac-resynchronization therapy for mild-to-moderate heart failure","volume":"363","author":"Tang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib9","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/01.CIR.0000065226.24159.E9","article-title":"Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure","volume":"107","author":"John Sutton","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCULATIONAHA.104.520817","article-title":"Sustained reverse left ventricular structural remodeling with cardiac resynchronization at one year is a function of etiology: quantitative Doppler echocardiographic evidence from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE)","volume":"113","author":"John Sutton","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib11","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/CIRCULATIONAHA.110.014324","article-title":"Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT)","volume":"124","author":"Goldenberg","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib12","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/CIRCULATIONAHA.110.955039","article-title":"Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: Multicenter Automatic Defibrillator Implantation Trial \u2013 Cardiac Resynchronization Therapy","volume":"122","author":"Solomon","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.amjcard.2007.10.027","article-title":"Reverse of left ventricular volumetric and structural remodeling in heart failure patients treated with cardiac resynchronization therapy","volume":"101","author":"Soliman","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib14","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/CIRCULATIONAHA.108.818724","article-title":"Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I\/II heart failure","volume":"120","author":"John Sutton","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1542-474X.2005.00073.x","article-title":"Multicenter Automatic Defibrillator Implantation Trial \u2013 Cardiac Resynchronization Therapy (MADIT-CRT): design and clinical protocol","volume":"10","author":"Moss","year":"2005","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib16","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.11.007_bib17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCULATIONAHA.110.960898","article-title":"Effectiveness of cardiac resynchronization therapy by QRS morphology in the Multicenter Automatic Defibrillator Implantation Trial \u2013 Cardiac Resynchronization Therapy (MADIT-CRT)","volume":"123","author":"Zareba","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib18","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.hrthm.2012.11.007_bib19","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","article-title":"Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings","volume":"57","author":"Devereux","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib20","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.jacc.2010.12.041","article-title":"Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial \u2013 Cardiac Resynchronization Therapy)","volume":"57","author":"Barsheshet","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib21","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/01.CIR.0000070420.51787.A8","article-title":"Left ventricular remodeling and ventricular arrhythmias after myocardial infarction","volume":"107","author":"St John Sutton","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/01.CIR.89.1.68","article-title":"Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction: the protective effects of captopril","volume":"89","author":"St John Sutton","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.11.007_bib23","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/eurheartj\/ehi885","article-title":"Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure","volume":"27","author":"Zhang","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2012.11.007_bib24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1161\/CIRCGENETICS.108.832345","article-title":"Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level","volume":"2","author":"Barth","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.hrthm.2012.11.007_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jacc.2007.07.087","article-title":"Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders","volume":"51","author":"Vanderheyden","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejheart.2006.06.005","article-title":"Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin","volume":"9","author":"Francia","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.hrthm.2012.11.007_bib27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/eurheartj\/ehi579","article-title":"Effects of biventricular pacing on interstitial remodelling, tumor necrosis factor-alpha expression, and apoptotic death in failing human myocardium","volume":"27","author":"D\u2019Ascia","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2012.11.007_bib28","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.lfs.2007.08.022","article-title":"Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy","volume":"81","author":"Nishijima","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.hrthm.2012.11.007_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1540-8159.1997.tb06199.x","article-title":"Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias","volume":"20","author":"Spach","year":"1997","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2012.11.007_bib30","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.CIR.88.3.915","article-title":"Slow conduction in the infarcted human heart: \"zigzag\" course of activation","volume":"88","author":"de Bakker","year":"1993","journal-title":"Circulation"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527112013355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527112013355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:45:23Z","timestamp":1761547523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527112013355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1547527112013355"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2012.11.007","relation":{},"ISSN":["1547-5271"],"issn-type":[{"type":"print","value":"1547-5271"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2012.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}