{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:13:44Z","timestamp":1773245624074,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.hrthm.2012.12.025","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T23:50:25Z","timestamp":1356652225000},"page":"668-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The anatomic and electrical location of the left ventricular lead predicts ventricular arrhythmia in cardiac resynchronization therapy"],"prefix":"10.1016","volume":"10","author":[{"given":"Daniel J.","family":"Friedman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav A.","family":"Upadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert K.","family":"Altman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Orencole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor D.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theofanie","family":"Mela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kevin Heist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagmeet P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2012.12.025_bib1","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.12.025_bib2","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/eurheartj\/ehl099","article-title":"Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2012.12.025_bib3","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.12.025_bib5","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2012.12.025_bib6","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.jacc.2010.12.041","article-title":"Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)","volume":"57","author":"Barsheshet","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib7","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/j.jacc.2005.04.067","article-title":"Impact of upgrade to cardiac resynchronization therapy on ventricular arrhythmia frequency in patients with implantable cardioverter-defibrillators","volume":"46","author":"Ermis","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.hrthm.2010.12.031","article-title":"The impact of cardiac resynchronization therapy on the incidence of ventricular arrhythmias in mild heart failure","volume":"8","author":"Gold","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2012.12.025_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1540-8167.2008.01317.x","article-title":"Relationship of reverse anatomical remodeling and ventricular arrhythmias after cardiac resynchronization","volume":"20","author":"Markowitz","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib10","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.jacc.2011.07.020","article-title":"Cardiac resynchronization therapy reduces left atrial volume and the risk of atrial tachyarrhythmias in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)","volume":"58","author":"Brenyo","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib11","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"issue":"8 Suppl","key":"10.1016\/j.hrthm.2012.12.025_bib12","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.hrthm.2012.04.022","article-title":"Contemporary and future trends in cardiac resynchronization therapy to enhance response","volume":"9","author":"Exner","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2012.12.025_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10741-010-9212-4","article-title":"Lead positioning strategies to enhance response to cardiac resynchronization therapy","volume":"16","author":"Blendea","year":"2011","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.hrthm.2012.12.025_bib14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.hrthm.2010.01.035","article-title":"Impact of segmental left ventricle lead position on cardiac resynchronization therapy outcomes","volume":"7","author":"Merchant","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2012.12.025_bib15","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.110.000646","article-title":"Left ventricular lead position and clinical outcome in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) trial","volume":"123","author":"Singh","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib16","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1093\/eurheartj\/ehr329","article-title":"The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy","volume":"32","author":"Gold","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2012.12.025_bib17","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.hrthm.2006.07.034","article-title":"Left ventricular lead electrical delay predicts response to cardiac resynchronization therapy","volume":"3","author":"Singh","year":"2006","journal-title":"Heart Rhythm"},{"issue":"21","key":"10.1016\/j.hrthm.2012.12.025_bib18","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1093\/eurheartj\/ehr505","article-title":"Sites of left and right ventricular lead implantation and response to cardiac resynchronization therapy observations from the REVERSE trial","volume":"33","author":"Thebault","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2012.12.025_bib19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.CIR.0000118502.91105.F6","article-title":"Characterization of left ventricular activation in patients with heart failure and left bundle-branch block","volume":"109","author":"Auricchio","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/heart.90.1.17","article-title":"Variable left ventricular activation pattern in patients with heart failure and left bundle branch block","volume":"90","author":"Fung","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2012.12.025_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1540-8167.2003.02421.x","article-title":"Variable patterns of septal activation in patients with left bundle branch block and heart failure","volume":"14","author":"Rodriguez","year":"2003","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib22","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1161\/hc5001.102229","article-title":"Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients","volume":"104","author":"Butter","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib23","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jtcvs.2003.10.052","article-title":"Epicardial left ventricular lead placement for cardiac resynchronization therapy: optimal pace site selection with pressure-volume loops","volume":"127","author":"Dekker","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.hrthm.2012.12.025_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/01.CIR.0000048126.07819.37","article-title":"Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?","volume":"107","author":"Medina-Ravell","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib25","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.hrthm.2005.05.019","article-title":"Potential proarrhythmic effect of biventricular pacing: fact or myth?","volume":"2","author":"Shukla","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2012.12.025_bib26","first-page":"499","article-title":"The magnitude of sympathoneural activation in advanced heart failure is altered with chronic biventricular pacing [abstract]","volume":"21","author":"Saxon","year":"1998","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib27","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jacc.2008.07.043","article-title":"Antiarrhythmic effect of reverse ventricular remodeling induced by cardiac resynchronization therapy: the InSync ICD (Implantable Cardioverter-Defibrillator) Italian Registry","volume":"52","author":"Di Biase","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib28","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/CIRCULATIONAHA.110.955039","article-title":"Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy","volume":"122","author":"Solomon","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.amjcard.2007.10.027","article-title":"Reverse of left ventricular volumetric and structural remodeling in heart failure patients treated with cardiac resynchronization therapy","volume":"101","author":"Soliman","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0735-1097(02)01932-0","article-title":"Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study","volume":"40","author":"Linde","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib31","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1161\/01.CIR.98.21.2334","article-title":"Sudden cardiac death","volume":"98","author":"Zipes","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib32","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0735-1097(00)00795-6","article-title":"Ventak CHF Investigators. Biventricular pacing diminishes the need for implantable cardioverter defibrillator therapy","volume":"36","author":"Higgins","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib33","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.jacc.2008.02.040","article-title":"Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy","volume":"51","author":"Delgado","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2012.12.025_bib34","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1161\/CIRCULATIONAHA.106.677005","article-title":"Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline","volume":"116","author":"Bleeker","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2012.12.025_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10840-010-9470-z","article-title":"Impact of left ventricular lead position on the incidence of ventricular arrhythmia and clinical outcome in patients with cardiac resynchronization therapy","volume":"28","author":"Kleemann","year":"2010","journal-title":"J Interv Card Electrophysiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527112015317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527112015317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:45:34Z","timestamp":1761547534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527112015317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S1547527112015317"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2012.12.025","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anatomic and electrical location of the left ventricular lead predicts ventricular arrhythmia in cardiac resynchronization therapy","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2012.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}