{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:07:53Z","timestamp":1780988873859,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.hrthm.2014.04.042","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T14:32:36Z","timestamp":1399645956000},"page":"1446-1453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy"],"prefix":"10.1016","volume":"11","author":[{"given":"Thomas M.","family":"Beckermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Murday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Potet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Alfred L.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2014.04.042_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1172\/JCI62928","article-title":"Molecular and genetic basis of sudden cardiac death","volume":"123","author":"George","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hrthm.2014.04.042_bib2","series-title":"Cardiac Electrophysiology: From Cell to Bedside","article-title":"Mechanisms in heritable sodium channel diseases","author":"George","year":"2014"},{"key":"10.1016\/j.hrthm.2014.04.042_bib3","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/01.CIR.0000144458.58660.BB","article-title":"SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia","volume":"110","author":"McNair","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2014.04.042_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/jama.293.4.447","article-title":"Sodium channel mutations and susceptibility to heart failure and atrial fibrillation","volume":"293","author":"Olson","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2014.04.042_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCRESAHA.107.164673","article-title":"Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia","volume":"102","author":"Nguyen","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2014.04.042_bib6","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1161\/CIRCULATIONAHA.109.931220","article-title":"Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy","volume":"121","author":"Morales","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2014.04.042_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jacc.2012.02.052","article-title":"Multifocal Ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy","volume":"60","author":"Laurent","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2014.04.042_bib8","doi-asserted-by":"crossref","first-page":"e38331","DOI":"10.1371\/journal.pone.0038331","article-title":"A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype","volume":"7","author":"Gosselin-Badaroudine","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.hrthm.2014.04.042_bib9","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1016\/j.jacc.2010.09.084","article-title":"SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism","volume":"57","author":"McNair","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2014.04.042_bib10","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.hrthm.2012.06.029","article-title":"Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q","volume":"9","author":"Nair","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2014.04.042_bib11","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.jacc.2012.05.050","article-title":"R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy","volume":"60","author":"Mann","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2014.04.042_bib12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/376683a0","article-title":"Molecular mechanism for an inherited cardiac arrhythmia","volume":"376","author":"Bennett","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.hrthm.2014.04.042_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1399-0004.2006.00671.x","article-title":"Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome","volume":"70","author":"Millat","year":"2006","journal-title":"Clin Genet"},{"key":"10.1016\/j.hrthm.2014.04.042_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.RES.0000052672.97759.36","article-title":"Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system","volume":"92","author":"Bezzina","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2014.04.042_bib15","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/01.CIR.97.7.640","article-title":"Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel","volume":"97","author":"Kambouris","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2014.04.042_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0014-5793(98)00033-7","article-title":"A de novo missense mutation of human cardiac Na+ channel exhibiting novel molecular mechanisms of long QT syndrome","volume":"423","author":"Makita","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1016\/j.hrthm.2014.04.042_bib17","doi-asserted-by":"crossref","first-page":"13200","DOI":"10.1073\/pnas.93.23.13200","article-title":"Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome","volume":"93","author":"Wang","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hrthm.2014.04.042_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0896-6273(00)80680-7","article-title":"Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation","volume":"22","author":"Cha","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.hrthm.2014.04.042_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1752-8062.2010.00249.x","article-title":"SCN5A rare variants in familial dilated cardiomyopathy decrease peak sodium current depending on the common polymorphism H558R and common splice variant Q1077del","volume":"3","author":"Cheng","year":"2010","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.hrthm.2014.04.042_bib20","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0008-6363(02)00656-9","article-title":"Intracellular Na+ regulation in cardiac myocytes","volume":"57","author":"Bers","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2014.04.042_bib21","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0008-6363(02)00841-6","article-title":"[Na+]i handling in the failing human heart","volume":"57","author":"Pieske","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2014.04.042_bib22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/01.RES.0000232546.92777.05","article-title":"Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes","volume":"99","author":"Maack","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2014.04.042_bib23","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.109.914911","article-title":"Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes","volume":"121","author":"Kohlhaas","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2014.04.042_bib24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1152\/jn.00438.2012","article-title":"The response of NaV1.3 sodium channels to ramp stimuli: multiple components and mechanisms","volume":"109","author":"Estacion","year":"2013","journal-title":"J Neurophysiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527114005049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527114005049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T08:23:11Z","timestamp":1538641391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527114005049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1547527114005049"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2014.04.042","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2014.04.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}