{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:36:59Z","timestamp":1792157819363,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartrhythmjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.hrthm.2014.07.031","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T19:16:26Z","timestamp":1406315786000},"page":"2047-2053","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Correlation of maternal flecainide concentrations and therapeutic effect in fetal supraventricular tachycardia"],"prefix":"10.1016","volume":"11","author":[{"given":"Trisha V.","family":"Vigneswaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurleen K.","family":"Sharland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2014.07.031_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/hrt.65.1.46","article-title":"Flecainide in the treatment of fetal tachycardias","volume":"65","author":"Allan","year":"1991","journal-title":"Br Heart J"},{"key":"10.1016\/j.hrthm.2014.07.031_bib2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/hrt.79.6.576","article-title":"Fetal tachycardia: management and outcome of 127 consecutive cases","volume":"79","author":"Simpson","year":"1998","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.0960-7692.2001.00562.x","article-title":"Flecainide in the intrauterine treatment of fetal supraventricular Tachycardia","volume":"19","author":"Krapp","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/heart.89.8.913","article-title":"Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia","volume":"89","author":"Krapp","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib5","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1161\/CIRCULATIONAHA.111.026120","article-title":"Comparison of transplacental treatment of\u00a0fetal\u00a0supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study","volume":"124","author":"Jaeggi","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2014.07.031_bib6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1017\/S1047951111001272","article-title":"Rapid control of foetal supraventricular tachycardia with digoxin and\u00a0flecainide\u00a0combination treatment","volume":"22","author":"Uzun","year":"2012","journal-title":"Cardiol Young"},{"key":"10.1016\/j.hrthm.2014.07.031_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/clpt.1985.37","article-title":"Effect of flecainide on cardiac output. (abstract)","volume":"37","author":"Muhiddin","year":"1985","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.hrthm.2014.07.031_bib8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJM198108273050901","article-title":"Oral flecainide acetate for the treatment of ventricular arrhythmias","volume":"305","author":"Anderson","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2014.07.031_bib9","doi-asserted-by":"crossref","first-page":"59B","DOI":"10.1016\/0002-9149(84)90504-6","article-title":"Flecainide dose-response relations in stable ventricular arrhythmias","volume":"53","author":"Woosley","year":"1984","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/00007691-200010000-00013","article-title":"Digoxin flecainide, and amiodarone transfer across the placenta and the effects of an elevated umbilical venous pressure on the transfer rate","volume":"22","author":"Schmolling","year":"2000","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.hrthm.2014.07.031_bib11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM199103213241201","article-title":"Mortality and morbidity in patients receiving encainide, flecainide, or placebo: the Cardiac Arrhythmia Suppression Trial","volume":"324","author":"Echt","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2014.07.031_bib12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/heart.89.4.470-a","article-title":"Neonatal ECG changes caused by supratherapeutic flecainide following treatment for fetal supraventricular tachycardia","volume":"89","author":"Rasheed","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/hrt.50.3.240","article-title":"Evaluation of fetal arrhythmias by echocardiography","volume":"50","author":"Allan","year":"1983","journal-title":"Br Heart J"},{"key":"10.1016\/j.hrthm.2014.07.031_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9149(83)80042-3","article-title":"Fetal echocardiography: a tool for evaluation of in utero cardiac arrhythmias and monitoring of in utero therapy: analysis of 71 patients","volume":"51","author":"Kleinman","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib15","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/0002-9149(92)90858-V","article-title":"Supraventricular tachycardia mechanisms and their age distribution in pediatric patients","volume":"69","author":"Ko","year":"1992","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/hrt.79.6.582","article-title":"Ventriculo-atrial time interval measured on M mode echocardiography: a determining element in diagnosis, treatment, and prognosis of fetal supraventricular tachycardia","volume":"79","author":"Jaeggi","year":"1998","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib17","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/hrt.79.6.536","article-title":"Mechanisms of fetal tachycardia","volume":"79","author":"Wren","year":"1998","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/uog.6433","article-title":"Fetal ventricular tachycardia secondary to long QT syndrome treated with maternal intravenous magnesium: case report and review of the literature","volume":"34","author":"Simpson","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib19","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1136\/heart.89.10.1211","article-title":"Management of fetal tachyarrhythmia based on superior vena cava\/aorta Doppler flow recordings","volume":"89","author":"Fouron","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib20","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/hrt.2006.101659","article-title":"Evaluation of fetal arrhythmias from simultaneous pulsed wave Doppler in pulmonary artery and vein","volume":"93","author":"Carvalho","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib21","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1136\/hrt.2005.069369","article-title":"Rhythm abnormalities of the fetus","volume":"93","author":"Hornberger","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2014.07.031_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s002469900118","article-title":"Outcome of intermittent tachyarrhythmias in the fetus","volume":"18","author":"Simpson","year":"1997","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0378-4347(00)84119-5","article-title":"High performance liquid chromatographic method for the measurement of mexiletine and flecainide in blood plasma or serum","volume":"11","author":"Bhamra","year":"1984","journal-title":"J Chromatogr"},{"issue":"Suppl","key":"10.1016\/j.hrthm.2014.07.031_bib24","doi-asserted-by":"crossref","first-page":"25S","DOI":"10.1093\/bja\/51.suppl_1.25S","article-title":"Placental transfer and fetal uptake of drugs","volume":"51","author":"Finster","year":"1979","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.hrthm.2014.07.031_bib25","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00246-005-0974-8","article-title":"Transplacental pharmacokinetics of flecainide in the gravid baboon and fetus","volume":"26","author":"Dimas","year":"2005","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/bmj.296.6617.249","article-title":"Maternal administration of flecainide to terminate and suppress fetal tachycardia","volume":"296","author":"Wren","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.hrthm.2014.07.031_bib27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1177\/106002809402800907","article-title":"Flecainide distribution, transplacental passage, and accumulation in the amniotic fluid during the third trimester of pregnancy. (abstract)","volume":"28","author":"Bourget","year":"1994","journal-title":"Ann Pharmacother."},{"key":"10.1016\/j.hrthm.2014.07.031_bib28","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1471-0528.1991.tb13511.x","article-title":"Fetal blood sampling and pregnancy loss in relation to indication. (abstract)","volume":"98","author":"Maxwell","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib29","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.siny.2005.12.001","article-title":"Cardiac arrhythmias in the fetus and newborn","volume":"11","author":"Wren","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.hrthm.2014.07.031_bib30","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.AOG.0000197063.25177.69","article-title":"Fetal and maternal magnetocardiography during flecainide therapy for supraventricular tachycardia","volume":"108","author":"Campbell","year":"2006","journal-title":"Obstet Gynaecol"},{"key":"10.1016\/j.hrthm.2014.07.031_bib31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.hrthm.2008.02.035","article-title":"Magnetocardiography for fetal arrhythmias","volume":"5","author":"Strasburger","year":"2008","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2014.07.031_bib32","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/01.CIR.0000031571.92807.CC","article-title":"Use of tissue velocity imaging in the diagnosis of fetal cardiac arrhythmias","volume":"106","author":"Rein","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2014.07.031_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2459\/JCM.0b013e3281053bf1","article-title":"The challenge of fetal dysrhythmias: electrocardiographic diagnosis and clinical management","volume":"9","author":"D\u2019Alto","year":"2008","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.hrthm.2014.07.031_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0002-8703(87)90011-1","article-title":"Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers. (abstract)","volume":"113","author":"Yabek","year":"1987","journal-title":"Am Heart J"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527114008042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527114008042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T05:59:17Z","timestamp":1538373557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527114008042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1547527114008042"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2014.07.031","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation of maternal flecainide concentrations and therapeutic effect in fetal supraventricular tachycardia","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2014.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}