{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:52:48Z","timestamp":1789203168557,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartrhythmjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.hrthm.2015.04.001","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T21:31:21Z","timestamp":1428269481000},"page":"1476-1482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Incidence and characteristics of complications in the setting of second-generation cryoballoon ablation: A large single-center study of 500 consecutive patients"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-9418","authenticated-orcid":false,"given":"Giacomo","family":"Mugnai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ciconte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazala","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedran","family":"Velagic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Str\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"H\u00fcn\u00fck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian-Battista","family":"Chierchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2015.04.001_bib1","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.hrthm.2011.03.050","article-title":"Efficacy and safety of cryoballoon ablation for atrial fibrillation: a systematic review of published studies","volume":"8","author":"Andrade","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/jce.12409","article-title":"One-year follow-up after single procedure Cryoballoon ablation: a comparison between the first and second generation balloon","volume":"25","author":"Di Giovanni","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/CIRCEP.114.001473","article-title":"One-year clinical outcome after pulmonary vein isolation using the second-generation 28-mm cryoballoon","volume":"7","author":"Metzner","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib4","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.hrthm.2013.07.005","article-title":"Phrenic nerve paralysis during cryoballoon ablation for atrial fibrillation: a comparison between the first- and second-generation balloon","volume":"10","author":"Casado-Arroyo","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.hrthm.2013.01.011","article-title":"Immediate balloon deflation for prevention of persistent phrenic nerve palsy during pulmonary vein isolation by balloon cryoablation","volume":"10","author":"Ghosh","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10840-014-9922-y","article-title":"Periprocedural outcomes of prophylactic protamine administration for reversal of heparin after cryoballoon ablation of atrial fibrillation","volume":"41","author":"Conte","year":"2014","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.hrthm.2014.12.026","article-title":"Single 3-minute freeze for second-generation cryoballoon ablation: one-year follow up after pulmonary vein isolation","volume":"12","author":"Ciconte","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1540-8167.2009.01493.x","article-title":"Complications of atrial fibrillation in a high-volume center in 1,000 procedures: still cause for concern?","volume":"20","author":"Dagres","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCEP.109.859116","article-title":"Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation","volume":"3","author":"Cappato","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1540-8167.2010.01995.x","article-title":"Prevalence and predictors of complications of radiofrequency catheter ablation for atrial fibrillation","volume":"22","author":"Baman","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s11936-014-0344-z","article-title":"Complications from catheter ablation of atrial fibrillation: impact of current and emerging ablation technologies","volume":"16","author":"Panda","year":"2014","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1016\/j.hrthm.2015.04.001_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.hrthm.2009.10.025","article-title":"Outcomes and complications of catheter ablation for atrial fibrillation in females","volume":"7","author":"Patel","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib13","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/01.CIR.0000058706.82623.A1","article-title":"Lower incidence of thrombus formation with cryoenergy versus radiofrequency catheter ablation","volume":"107","author":"Khairy","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2015.04.001_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0972-6292(16)30479-X","article-title":"Cryoballoon ablation for atrial fibrillation","volume":"12","author":"Andrade","year":"2012","journal-title":"Indian Pacing Electrophysiol J"},{"key":"10.1016\/j.hrthm.2015.04.001_bib15","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.jacc.2012.09.033","article-title":"Long-term outcomes after cryoballoon pulmonary vein isolation: results from a prospective study in 605 patients","volume":"61","author":"Vogt","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/europace\/euu320","article-title":"Incidence and characteristics of phrenic nerve palsy following pulmonary vein isolation with the second-generation as compared with the first-generation cryoballoon in 360 consecutive patients","volume":"17","author":"Furnkranz","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2015.04.001_bib17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.hrthm.2011.01.031","article-title":"Diaphragmatic electromyography during cryoballoon ablation: a novel concept in the prevention of phrenic nerve palsy","volume":"8","author":"Franceschi","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/CIRCEP.113.000228","article-title":"Increased incidence of esophageal thermal lesions using the second-generation 28-mm cryoballoon","volume":"6","author":"Metzner","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.hrthm.2013.02.021","article-title":"Luminal esophageal temperature predicts esophageal lesions after second-generation cryoballoon pulmonary vein isolation","volume":"10","author":"Furnkranz","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.04.001_bib20","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1540-8167.2011.02219.x","article-title":"Collateral nervous damages after cryoballoon pulmonary vein isolation","volume":"23","author":"Guiot","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.04.001_bib21","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1540-8167.2011.02031.x","article-title":"Hemoptysis after pulmonary vein isolation with a cryoballoon: an analysis of the potential etiology","volume":"22","author":"Bhagwandien","year":"2011","journal-title":"J Cardiovasc Electrophysiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527115004142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527115004142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T17:58:52Z","timestamp":1537725532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527115004142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1547527115004142"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2015.04.001","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence and characteristics of complications in the setting of second-generation cryoballoon ablation: A large single-center study of 500 consecutive patients","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2015.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}