{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:06:30Z","timestamp":1771851990125,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartrhythmjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.hrthm.2015.09.015","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T09:04:24Z","timestamp":1442826264000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation"],"prefix":"10.1016","volume":"13","author":[{"given":"Pak-Hei","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo Jo","family":"Hai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Xue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian C.K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-Pak","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chern-En","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Fat","family":"Tse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Wah","family":"Siu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2015.09.015_bib1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0140-6736(11)61514-6","article-title":"Atrial fibrillation","volume":"379","author":"Lip","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.hrthm.2015.09.015_bib2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hrthm.2015.09.015_bib3","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/eurheartj\/ehs253","volume":"33","author":"Camm","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2015.09.015_bib4","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1161\/CIR.0000000000000040","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society","volume":"130","author":"January","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2015.09.015_bib5","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.STR.26.8.1471","article-title":"Oral anticoagulants and intracranial hemorrhage: facts and hypotheses","volume":"26","author":"Hart","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.hrthm.2015.09.015_bib6","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/eurheartj\/ehr488","article-title":"Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study","volume":"33","author":"Friberg","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2015.09.015_bib7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0140-6736(07)61233-1","article-title":"Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial","volume":"370","author":"Mant","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.hrthm.2015.09.015_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000077341","article-title":"Incidence of cerebral hemorrhage in the Changsha community: a prospective study from 1986 to 2000","volume":"17","author":"Yang","year":"2004","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.hrthm.2015.09.015_bib9","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/01.STR.0000087149.42294.8C","article-title":"Proportion of different subtypes of stroke in China","volume":"34","author":"Zhang","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.hrthm.2015.09.015_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1161\/CIRCEP.113.000858","article-title":"Net clinical benefit of warfarin therapy in elderly Chinese patients with atrial fibrillation","volume":"7","author":"Siu","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2015.09.015_bib11","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1161\/STROKEAHA.114.008581","article-title":"Response to letter regarding article, \u201cIschemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control.\u201d","volume":"46","author":"Chan","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.hrthm.2015.09.015_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1179\/1743132813Y.0000000275","article-title":"Warfarin associated intracerebral hemorrhage in Hong Kong Chinese","volume":"36","author":"Teo","year":"2014","journal-title":"Neurol Res"},{"key":"10.1016\/j.hrthm.2015.09.015_bib13","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jacc.2014.12.067","article-title":"One more \u201cC\u201d for CHA2DS2-VASc score?","volume":"65","author":"Siu","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2015.09.015_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/archinte.1995.00430030071008","article-title":"Physician attitudes about anticoagulation for nonvalvular atrial fibrillation in the elderly","volume":"155","author":"McCrory","year":"1995","journal-title":"Archiv Intern Med"},{"key":"10.1016\/j.hrthm.2015.09.015_bib15","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijcard.2014.11.182","article-title":"Non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in Asian patients with atrial fibrillation: time for a reappraisal","volume":"180","author":"Lip","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2015.09.015_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1378\/chest.06-2733","article-title":"Transient atrial fibrillation complicating acute inferior myocardial infarction: implications for future risk of ischemic stroke","volume":"132","author":"Siu","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.hrthm.2015.09.015_bib17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.amjcard.2008.10.019","article-title":"Comparison of atrial fibrillation recurrence rates after successful electrical cardioversion in patients with hyperthyroidism-induced versus non-hyperthyroidism-induced persistent atrial fibrillation","volume":"103","author":"Siu","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2015.09.015_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.hrthm.2008.10.023","article-title":"Risk of ischemic stroke after new-onset atrial fibrillation in patients with hyperthyroidism","volume":"6","author":"Siu","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.09.015_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1160\/TH11-11-0807","article-title":"Transient atrial fibrillation complicating acute myocardial infarction: a nuisance or a nemesis?","volume":"107","author":"Lam","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.hrthm.2015.09.015_bib20","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1161\/CIRCULATIONAHA.111.055079","article-title":"Net clinical benefit of warfarin in patients with atrial fibrillation: a report from the Swedish atrial fibrillation cohort study","volume":"125","author":"Friberg","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2015.09.015_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on Atrial Fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.hrthm.2015.09.015_bib22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.hrthm.2015.09.015_bib23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0038-1651587","article-title":"A method to determine the optimal intensity of oral anticoagulant therapy","volume":"69","author":"Rosendaal","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.hrthm.2015.09.015_bib24","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Jauch","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.hrthm.2015.09.015_bib25","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1016\/j.wneu.2013.02.070","article-title":"Predictive value of the HAS-BLED score for the risk of recurrent intracranial hemorrhage after first spontaneous intracranial hemorrhage","volume":"82","author":"Chan","year":"2014","journal-title":"World Neurosurg"},{"key":"10.1016\/j.hrthm.2015.09.015_bib26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s12311-012-0371-9","article-title":"Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage","volume":"11","author":"Pong","year":"2012","journal-title":"Cerebellum"},{"key":"10.1016\/j.hrthm.2015.09.015_bib27","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"New Engl J Med"},{"key":"10.1016\/j.hrthm.2015.09.015_bib28","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"New Engl J Med"},{"key":"10.1016\/j.hrthm.2015.09.015_bib29","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"New Engl J Med"},{"key":"10.1016\/j.hrthm.2015.09.015_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.STR.21.2.230","article-title":"Cerebrovascular disease in Hong Kong Chinese","volume":"21","author":"Huang","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.hrthm.2015.09.015_bib31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1056\/NEJMc1112874","article-title":"Bleeding risk with dabigatran in the frail elderly","volume":"366","author":"Harper","year":"2012","journal-title":"New Engl J Med"},{"key":"10.1016\/j.hrthm.2015.09.015_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/FJC.0b013e31821cd888","article-title":"Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation","volume":"58","author":"Chan","year":"2011","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.hrthm.2015.09.015_bib33","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/jhh.2010.57","article-title":"Safety and efficacy of oral anticoagulation therapy in Chinese patients with concomitant atrial fibrillation and hypertension","volume":"25","author":"Ho","year":"2011","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.hrthm.2015.09.015_bib34","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.hrthm.2013.03.017","article-title":"Stroke prevention in atrial fibrillation\u2014an Asian stroke perspective","volume":"10","author":"Tse","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2015.09.015_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jacc.2013.07.104","article-title":"The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)","volume":"63","author":"Reilly","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2015.09.015_bib36","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1253\/circj.CJ-15-0594","article-title":"RE-LY Investigators. Efficacy and safety of dabigatran etexilate vs. warfarin in Asian RE-LY patients according to baseline renal function or CHADS2 score","volume":"79","author":"Hori","year":"2015","journal-title":"Circ J"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527115011856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527115011856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T16:30:11Z","timestamp":1567182611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527115011856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1547527115011856"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2015.09.015","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2015.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}