{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:47:11Z","timestamp":1791352031000,"version":"4.3.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartrhythmjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.hrthm.2016.02.013","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T09:45:34Z","timestamp":1456393534000},"page":"1274-1282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Impact of clinical and genetic findings on the management of young patients with Brugada syndrome"],"prefix":"10.1016","volume":"13","author":[{"given":"Antoine","family":"Andorin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah R.","family":"Behr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Denjoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Dagradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Sacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Maltret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie C.H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Degand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Bertaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Maury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Delasalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Gourraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Babuty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico A.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.","family":"Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Probst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2016.02.013_bib1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/CIRCULATIONAHA.109.887026","article-title":"Long-term prognosis of patients diagnosed with Brugada syndrome: results from the FINGER Brugada Syndrome Registry","volume":"121","author":"Probst","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2016.02.013_bib3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/CIRCEP.111.964577","article-title":"Brugada syndrome","volume":"5","author":"Mizusawa","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib4","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jacc.2012.04.037","article-title":"Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: implications for genetic testing","volume":"60","author":"Crotti","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jacc.2013.04.044","article-title":"Impact of genetics on the clinical management of channelopathies","volume":"62","author":"Schwartz","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1540-8159.2005.40020.x","article-title":"Prevalence and clinical course of the juveniles with Brugada-type ECG in Japanese population","volume":"28","author":"Oe","year":"2005","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib7","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1161\/CIRCULATIONAHA.106.664219","article-title":"Clinical aspects and prognosis of Brugada syndrome in children","volume":"115","author":"Probst","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2016.02.013_bib8","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.jacc.2014.02.574","article-title":"Drug-induced Brugada syndrome in children: clinical features, device-based management, and long-term follow-up","volume":"63","author":"Conte","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib9","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/eurheartj\/ehq049","article-title":"Number of electrocardiogram leads displaying the diagnostic coved-type pattern in Brugada syndrome: a diagnostic consensus criterion to be revised","volume":"31","author":"Richter","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2016.02.013_bib10","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.hrthm.2013.05.014","article-title":"HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes","volume":"10","author":"Priori","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2016.02.013_bib11","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1001\/jama.2014.13752","article-title":"Follow-up from childhood to adulthood of individuals with family history of Brugada syndrome and normal electrocardiograms","volume":"312","author":"Conte","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2016.02.013_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/pace.12346","article-title":"Diagnosis and management of pediatric Brugada syndrome: a survey of pediatric electrophysiologists","volume":"37","author":"Harris","year":"2014","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1540-8167.2006.00743.x","article-title":"Sex hormone and gender difference\u2014role of testosterone on male predominance in Brugada syndrome","volume":"18","author":"Shimizu","year":"2007","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1536\/ihj.50.669","article-title":"A case of Brugada syndrome in which diurnal ECG changes were associated with circadian rhythms of sex hormones","volume":"50","author":"Yamaki","year":"2009","journal-title":"Int Heart J"},{"key":"10.1016\/j.hrthm.2016.02.013_bib15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1161\/CIRCEP.114.001818","article-title":"Cardiac evaluation of pediatric relatives in sudden arrhythmic death syndrome: a 2-center experience","volume":"7","author":"Wong","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-149-3-200808050-00020","article-title":"Fever increases the risk for cardiac arrest in the Brugada syndrome","volume":"149","author":"Amin","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hrthm.2016.02.013_bib17","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1046\/j.1460-9592.2002.01646.x","article-title":"Fever unmasking the Brugada syndrome","volume":"25","author":"Porres","year":"2002","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib18","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.hrthm.2013.07.030","article-title":"Fever-induced Brugada pattern: how common is it and what does it mean?","volume":"10","author":"Adler","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2016.02.013_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/01.RES.85.9.803","article-title":"Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent","volume":"85","author":"Dumaine","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2016.02.013_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.hrthm.2009.09.069","article-title":"An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing","volume":"7","author":"Kapplinger","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2016.02.013_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCGENETICS.111.961102","article-title":"Mortality of inherited arrhythmia syndromes: insight into their natural history","volume":"5","author":"Nannenberg","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.hrthm.2016.02.013_bib22","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.amjcard.2013.06.033","article-title":"Prevalence and prognostic role of various conduction disturbances in patients with the Brugada syndrome","volume":"112","author":"Maury","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib23","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/ng.2712","article-title":"Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death","volume":"45","author":"Bezzina","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.hrthm.2016.02.013_bib24","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ejhg.2012.289","article-title":"Genetics can contribute to the prognosis of Brugada syndrome: a pilot model for risk stratification","volume":"21","author":"Sommariva","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.hrthm.2016.02.013_bib25","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/europace\/eun214","article-title":"Epicardial and pleural lead ICD systems in children and adolescents maintain functionality over 5 years","volume":"10","author":"Tomaske","year":"2008","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2016.02.013_bib26","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/pace.12233","article-title":"Clinical experience of subcutaneous and transvenous implantable cardioverter defibrillators in children and teenagers","volume":"36","author":"Pettit","year":"2013","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.02.013_bib27","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/01.CIR.0000143159.30585.90","article-title":"Efficacy of quinidine in high-risk patients with Brugada syndrome","volume":"110","author":"Belhassen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2016.02.013_bib28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1540-8159.2008.02235.x","article-title":"Excellent long-term reproducibility of the electrophysiologic efficacy of quinidine in patients with idiopathic ventricular fibrillation and Brugada syndrome","volume":"32","author":"Belhassen","year":"2009","journal-title":"Pacing Clin Electrophysiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752711600182X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752711600182X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T22:22:42Z","timestamp":1536963762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154752711600182X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S154752711600182X"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2016.02.013","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of clinical and genetic findings on the management of young patients with Brugada syndrome","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2016.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Heart Rhythm Society. Published by Heart Rhythm Society All rights reserved.","name":"copyright","label":"Copyright"}]}}