{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:18:23Z","timestamp":1791317903666,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartrhythmjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.hrthm.2016.03.042","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T13:58:37Z","timestamp":1458655117000},"page":"1402-1409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Left atrial appendage morphology assessment for risk stratification of embolic stroke in patients with atrial fibrillation: A meta-analysis"],"prefix":"10.1016","volume":"13","author":[{"given":"Florentino","family":"Lupercio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Carlos Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Briceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Villablanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Berardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Faillace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Krumerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Ferrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2016.03.042_bib1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2016.03.042_bib2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/europace\/eus333","article-title":"Incidence and prevalence of atrial fibrillation: an analysis based on 8.3 million patients","volume":"15","author":"Wilke","year":"2013","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2016.03.042_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1212\/WNL.28.10.973","article-title":"Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study","volume":"28","author":"Wolf","year":"1978","journal-title":"Neurology"},{"key":"10.1016\/j.hrthm.2016.03.042_bib4","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.amjcard.2009.07.022","article-title":"Increasing prevalence of atrial fibrillation and flutter in the United States","volume":"104","author":"Naccarelli","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0003-4975(95)00887-X","article-title":"Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation","volume":"61","author":"Blackshear","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.hrthm.2016.03.042_bib6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.ahj.2006.05.001","article-title":"Potential applicability and utilization of left atrial appendage occlusion devices in patients with atrial fibrillation","volume":"152","author":"Fountain","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.hrthm.2016.03.042_bib7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1540-8167.2010.01814.x","article-title":"Left atrial appendage studied by computed tomography to help planning for appendage closure device placement","volume":"21","author":"Wang","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jacc.2012.04.032","article-title":"Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study","volume":"60","author":"Di Biase","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib9","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"Liberati","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hrthm.2016.03.042_bib10","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm. Accessed December 21, 2015."},{"key":"10.1016\/j.hrthm.2016.03.042_bib11","unstructured":"Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration. http:\/\/handbook.cochrane.org\/. Updated March 2011. Accessed December 21, 2015."},{"key":"10.1016\/j.hrthm.2016.03.042_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.hrthm.2016.03.042_bib13","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.hrthm.2016.03.042_bib14","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.hrthm.2016.03.042_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.hrthm.2016.03.042_bib16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.hrthm.2016.03.042_bib17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/europace\/euu347","article-title":"Left atrial appendage morphology is closely associated with specific echocardiographic flow pattern in patients with atrial fibrillation","volume":"17","author":"Petersen","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2016.03.042_bib18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/jce.12749","article-title":"Cardiogenic stroke despite low CHA2DS2-VASc score: Assessing Stroke risK by Left Atrial Appendage Anatomy (ASK LAA)","volume":"9","author":"Nedios","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib19","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/jce.12710","article-title":"Why is left atrial appendage morphology related to strokes? An analysis of the flow velocity and orifice size of the left atrial appendage","volume":"9","author":"Lee","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib20","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.3760\/cma.j.issn.0366-6999.20141520","article-title":"Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study","volume":"127","author":"Kong","year":"2014","journal-title":"Chin Med J"},{"key":"10.1016\/j.hrthm.2016.03.042_bib21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.hrthm.2013.01.036","article-title":"Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores","volume":"10","author":"Kimura","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2016.03.042_bib22","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.hrthm.2013.09.065","article-title":"Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation","volume":"10","author":"Khurram","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2016.03.042_bib23","first-page":"59","article-title":"Correlation between left atrial appendage morphology and flow velocity in patients with paroxysmal atrial fibrillation","volume":"17","author":"Fukushima","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2016.03.042_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.hrthm.2013.10.020","article-title":"Left atrial appendage morphology and silent cerebral ischemia in patients with atrial fibrillation","volume":"11","author":"Anselmino","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2016.03.042_bib25","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.echo.2014.08.016","article-title":"Prognostic significance of left atrial appendage \u201csludge\u201d in patients with atrial fibrillation: a new transesophageal echocardiographic thromboembolic risk factor","volume":"27","author":"Lowe","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.hrthm.2016.03.042_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.hrthm.2016.03.042_bib27","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib28","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/eurheartj\/ehs253","volume":"33","author":"Camm","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2016.03.042_bib29","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jacc.2015.01.044","article-title":"Oral anticoagulation, aspirin, or no therapy in patients with nonvalvular AF with 0 or 1 stroke risk factor based on the CHA2DS2-VASc score","volume":"65","author":"Lip","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib30","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/pace.12445","article-title":"Refinement of ischemic stroke risk in patients with atrial fibrillation and CHA2DS2-VASc score of 1","volume":"37","author":"Huang","year":"2014","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jacc.2014.11.046","article-title":"Should atrial fibrillation patients with 1 additional risk factor of the CHA2DS2-VASc score (beyond sex) receive oral anticoagulation?","volume":"65","author":"Chao","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib32","doi-asserted-by":"crossref","first-page":"d124","DOI":"10.1136\/bmj.d124","article-title":"Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study","volume":"342","author":"Olesen","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.hrthm.2016.03.042_bib33","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1540-8167.2011.02257.x","article-title":"Prognosis in patients with atrial fibrillation and CHA2DS2-VASc score = 0 in a community-based cohort study","volume":"23","author":"Taillandier","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2016.03.042_bib34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.hrthm.2016.03.042_bib35","first-page":"566","article-title":"Human left atrial appendage anatomy and overview of its clinical significance","volume":"13","author":"Ucerler","year":"2013","journal-title":"Anadolu Kardiyol Derg"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527116300868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527116300868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:41:30Z","timestamp":1718419290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527116300868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1547527116300868"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2016.03.042","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left atrial appendage morphology assessment for risk stratification of embolic stroke in patients with atrial fibrillation: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2016.03.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Heart Rhythm Society. Published by Heart Rhythm Society All rights reserved.","name":"copyright","label":"Copyright"}]}}