{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:56:55Z","timestamp":1779919015766,"version":"3.53.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","heartrhythmjournal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.hrthm.2017.05.027","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T03:04:24Z","timestamp":1497495864000},"page":"1531-1538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants"],"prefix":"10.1016","volume":"14","author":[{"given":"Emilie","family":"Gregers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0066-2779","authenticated-orcid":false,"given":"Gustav","family":"Ahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Jabbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstine O.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie B.","family":"Herfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer M.","family":"Henningsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Andreasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Thiis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Holme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Hauns\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo H.","family":"Bentzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper H.","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten S.","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2017.05.027_bib1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Ha\u00efssaguerre","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2017.05.027_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11936-015-0371-4","article-title":"Mechanisms Underlying AF: Triggers, Rotors, Other?","volume":"17","author":"Krummen","year":"2015","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1016\/j.hrthm.2017.05.027_bib3","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/CIRCULATIONAHA.111.039677","article-title":"Atrial fibrillation: current knowledge and future directions in epidemiology and genomics","volume":"124","author":"Magnani","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2017.05.027_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0140-6736(14)61774-8","article-title":"50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study","volume":"386","author":"Schnabel","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.hrthm.2017.05.027_bib5","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.CIR.0000083722.42033.0A","article-title":"Increasing trends in hospitalization for atrial fibrillation in the United States, 1985 through 1999: implications for primary prevention","volume":"108","author":"Wattigney","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2017.05.027_bib6","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2017.05.027_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ejhg.2013.139","article-title":"Atrial fibrillation: the role of common and rare genetic variants","volume":"22","author":"Olesen","year":"2014","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.hrthm.2017.05.027_bib8","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1056\/NEJMoa052800","article-title":"Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation","volume":"354","author":"Gollob","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2017.05.027_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/CIRCULATIONAHA.110.961227","article-title":"Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissue","volume":"122","author":"Thibodeau","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2017.05.027_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/CIRCGENETICS.114.000650","article-title":"Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation","volume":"8","author":"Roberts","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.hrthm.2017.05.027_bib11","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1001\/jama.291.23.2851","article-title":"Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring","volume":"291","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2017.05.027_bib12","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1161\/01.CIR.96.7.2455","article-title":"Rautaharju PM\/ Incidence of and risk factors for atrial fibrillation in older adults","volume":"96","author":"Psaty","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2017.05.027_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.hrthm.2017.05.027_bib14","doi-asserted-by":"crossref","first-page":"E2393","DOI":"10.1002\/humu.22376","article-title":"dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations","volume":"34","author":"Liu","year":"2013","journal-title":"Hum Mutat"},{"key":"10.1016\/j.hrthm.2017.05.027_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.hrthm.2017.05.027_bib17","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ajhg.2013.11.005","article-title":"Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes","volume":"93","author":"Lohmueller","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.hrthm.2017.05.027_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Consortium","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.hrthm.2017.05.027_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/jce.12666","article-title":"IKs gain- and loss-of-function in early-onset lone atrial fibrillation","volume":"26","author":"Steffensen","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2017.05.027_bib20","doi-asserted-by":"crossref","first-page":"e9021","DOI":"10.1371\/journal.pone.0009021","article-title":"Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics","volume":"5","author":"Larsen","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.hrthm.2017.05.027_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.hrthm.2005.01.020","article-title":"Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing","volume":"2","author":"Tester","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2017.05.027_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/physrev.00022.2013","article-title":"Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia","volume":"94","author":"Schmitt","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.hrthm.2017.05.027_bib23","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCULATIONAHA.114.009892","article-title":"Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation","volume":"130","author":"Sinner","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2017.05.027_bib24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.362","article-title":"Common variants at ten loci modulate the QT interval duration in the QTSCD Study","volume":"41","author":"Pfeufer","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.hrthm.2017.05.027_bib25","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.hrthm.2014.06.030","article-title":"Molecular diagnosis of long QT syndrome at 10 days of life by rapid whole genome sequencing","volume":"11","author":"Priest","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2017.05.027_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijcard.2008.05.050","article-title":"A novel KCNH2 mutation as a modifier for short QT interval","volume":"137","author":"Itoh","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2017.05.027_bib27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2174\/157340312803760721","article-title":"Triggers and Anatomical Substrates in the Genesis and Perpetuation of Atrial Fibrillation","volume":"8","author":"S\u00e1nchez-Quintana","year":"2012","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.hrthm.2017.05.027_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrcardio.2013.53","article-title":"Genetic mechanisms of atrial fibrillation: impact on response to treatment","volume":"10","author":"Darbar","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hrthm.2017.05.027_bib29","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0008-6363(99)00411-3","article-title":"Novel mutations in KvLQT1 that affect\u00a0Iks activation through interactions with Isk","volume":"45","author":"Chouabe","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2017.05.027_bib30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.hrthm.2017.05.027_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euje.2005.12.014","article-title":"Recommendations for chamber quantification","volume":"7","author":"Lang","year":"2006","journal-title":"Eur J Echocardiogr"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527117306410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527117306410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T11:13:53Z","timestamp":1571138033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527117306410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1547527117306410"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2017.05.027","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2017.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}