{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:11:52Z","timestamp":1786990312035,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL139829"],"award-info":[{"award-number":["R01 HL139829"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R42DA043391"],"award-info":[{"award-number":["R42DA043391"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TR0022080"],"award-info":[{"award-number":["TR0022080"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010506","name":"Indiana University Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670310"],"award-info":[{"award-number":["81670310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.hrthm.2018.10.033","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T03:07:12Z","timestamp":1542078432000},"page":"615-623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts"],"prefix":"10.1016","volume":"16","author":[{"given":"Juyi","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Thomas H.","family":"Everett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rubart-von der Lohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope A.","family":"Boyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2018.10.033_bib1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cardiores.2007.05.008","article-title":"Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites","volume":"75","author":"Ozgen","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib2","doi-asserted-by":"crossref","first-page":"49085","DOI":"10.1074\/jbc.M307508200","article-title":"Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts","volume":"278","author":"Xu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hrthm.2018.10.033_bib3","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.hrthm.2013.07.003","article-title":"Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium","volume":"10","author":"Chang","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2018.10.033_bib4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/CIRCEP.111.000152","article-title":"Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles","volume":"6","author":"Hsieh","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/CIRCRESAHA.107.161778","article-title":"Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes","volume":"102","author":"Zhang","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib6","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1113\/JP274249","article-title":"Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ \/Ca2+ exchange knockout mice","volume":"595","author":"Torrente","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib7","doi-asserted-by":"crossref","first-page":"e96691","DOI":"10.1371\/journal.pone.0096691","article-title":"Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2018.10.033_bib8","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/eci.12125","article-title":"Apamin modulates electrophysiological characteristics of the pulmonary vein and the Sinoatrial Node","volume":"43","author":"Chen","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.hrthm.2018.10.033_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.yjmcc.2009.07.019","article-title":"Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?","volume":"47","author":"Nagy","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCRESAHA.110.238386","article-title":"Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles","volume":"108","author":"Chua","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib11","doi-asserted-by":"crossref","first-page":"e005471","DOI":"10.1161\/JAHA.117.005471","article-title":"Small-conductance calcium-activated potassium current in normal rabbit cardiac Purkinje cells","volume":"6","author":"Reher","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2018.10.033_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/01.RES.24.3.361","article-title":"Interaction of transmembrane potentials in canine Purkinje fibers and at Purkinje fiber-muscle junctions","volume":"24","author":"Mendez","year":"1969","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib13","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/01.RES.21.4.537","article-title":"Interrelationship between automaticity and conduction in Purkinje fibers","volume":"21","author":"Singer","year":"1967","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib14","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.hrthm.2016.01.011","article-title":"Cardiac Purkinje fibers and arrhythmias: The GK Moe Award Lecture 2015","volume":"13","author":"Boyden","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2018.10.033_bib15","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/01.CIR.0000027564.55739.B1","article-title":"Mapping and ablation of idiopathic ventricular fibrillation","volume":"106","author":"Haissaguerre","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2018.10.033_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrcardio.2015.193","article-title":"Ventricular arrhythmias and the His-Purkinje system","volume":"13","author":"Haissaguerre","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib17","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/CIRCULATIONAHA.114.015125","article-title":"Small conductance calcium-activated potassium current is activated during hypokalemia and masks short term cardiac memory induced by ventricular pacing","volume":"132","author":"Chan","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2018.10.033_bib18","doi-asserted-by":"crossref","first-page":"H410","DOI":"10.1152\/ajpheart.00213.2013","article-title":"Ionic bases for electrical remodeling of the canine cardiac ventricle","volume":"305","author":"Jeyaraj","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1476-5381.2012.01995.x","article-title":"JTV519 (K201) reduces sarcoplasmic reticulum Ca(2+) leak and improves diastolic function in\u00a0vitro in ouabain-induced cellular Ca(2+) overload in murine and human non-failing myocardium","volume":"167","author":"Sacherer","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCRESAHA.109.206078","article-title":"A coupled system of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker","volume":"106","author":"Lakatta","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1152\/physrev.00011.2006","article-title":"Calcium and arrhythmogenesis","volume":"87","author":"ter Keurs","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.hrthm.2018.10.033_bib22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1540-8167.2010.01905.x","article-title":"Delayed afterdepolarization in intact canine sinoatrial node as a novel mechanism for atrial arrhythmia","volume":"22","author":"Joung","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib23","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/CIRCULATIONAHA.108.817379","article-title":"Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation","volume":"119","author":"Joung","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2018.10.033_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.hrthm.2004.03.068","article-title":"2APB- and JTV519(K201)-sensitive micro Ca2+ waves in arrhythmogenic Purkinje cells that survive in infarcted canine heart","volume":"1","author":"Boyden","year":"2004","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2018.10.033_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCEP.107.758110","article-title":"Function of Ca(2+) release channels in Purkinje cells that survive in the infarcted canine heart: a mechanism for triggered Purkinje ectopy","volume":"1","author":"Hirose","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/physrev.1993.73.1.197","article-title":"Cardiac pacemaking in the sinoatrial node","volume":"73","author":"Irisawa","year":"1993","journal-title":"Physiol Rev"},{"key":"10.1016\/j.hrthm.2018.10.033_bib27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000018627.89528.6F","article-title":"Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function","volume":"90","author":"Schram","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2018.10.033_bib28","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1073\/pnas.1505670112","article-title":"Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice","volume":"112","author":"Torrente","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.hrthm.2018.10.033_bib29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn1137","article-title":"The motor infrastructure: from ion channels to neuronal networks","volume":"4","author":"Grillner","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.hrthm.2018.10.033_bib30","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1161\/01.CIR.88.6.2607","article-title":"Radiofrequency catheter ablation of idiopathic left ventricular tachycardia guided by a Purkinje potential","volume":"88","author":"Nakagawa","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2018.10.033_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1540-8167.2004.03189.x","article-title":"Identification and ablation of three types of ventricular tachycardia involving the His-Purkinje system in patients with heart disease","volume":"15","author":"Lopera","year":"2004","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2018.10.033_bib32","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/01.CIR.0000088781.99943.95","article-title":"Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes","volume":"108","author":"Haissaguerre","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2018.10.033_bib33","doi-asserted-by":"crossref","first-page":"e70450","DOI":"10.1371\/journal.pone.0070450","article-title":"Amiodarone inhibits apamin-sensitive potassium currents","volume":"8","author":"Turker","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2018.10.033_bib34","doi-asserted-by":"crossref","first-page":"H375","DOI":"10.1152\/ajpheart.00479.2017","article-title":"Ondansetron blocks wildtype and p.F503L variant small conductance calcium activated potassium channels","volume":"315","author":"Ko","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527118311196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527118311196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:48:09Z","timestamp":1761547689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527118311196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1547527118311196"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2018.10.033","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2018.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}