{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:25:05Z","timestamp":1788391505304,"version":"build-2803163510"},"reference-count":18,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","heartrhythmjournal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.hrthm.2019.01.020","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T04:42:12Z","timestamp":1548564132000},"page":"1047-1056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Dynamic programming of atrioventricular delay improves electrical synchrony in a multicenter cardiac resynchronization therapy study"],"prefix":"10.1016","volume":"16","author":[{"given":"Bernard","family":"Thibault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-7897","authenticated-orcid":false,"given":"Kerstin","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Mond\u00e9sert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan O.","family":"Mangual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Badie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke C.","family":"McSpadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-6135","authenticated-orcid":false,"given":"Carlo","family":"Pappone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2019.01.020_bib1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/01.CIR.0000065226.24159.E9","article-title":"Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure","volume":"107","author":"St John Sutton","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2019.01.020_bib2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1056\/NEJM200103223441202","article-title":"Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay","volume":"344","author":"Cazeau","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2019.01.020_bib3","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2019.01.020_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.hfc.2016.07.019","article-title":"Cardiac resynchronization therapy: how to decrease nonresponders","volume":"13","author":"Tolosana","year":"2017","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.hrthm.2019.01.020_bib5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0735-1097(01)01747-8","article-title":"Retiming the failing heart: principles and current clinical status of cardiac resynchronization","volume":"39","author":"Leclercq","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.01.020_bib6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jacc.2008.11.024","article-title":"Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program","volume":"53","author":"Mullens","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.01.020_bib7","first-page":"1178","article-title":"Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function","volume":"19","author":"Jones","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2019.01.020_bib8","first-page":"1077","article-title":"Clinical relevance of systematic CRT device optimization","volume":"7","author":"Lunati","year":"2014","journal-title":"J Atr Fibrillation"},{"key":"10.1016\/j.hrthm.2019.01.020_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007489","article-title":"Programming cardiac resynchronization therapy for electrical synchrony: reaching beyond left bundle branch block and left ventricular activation delay","volume":"7","author":"Varma","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2019.01.020_bib10","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1161\/CIRCULATIONAHA.108.191095","volume":"119","author":"Surawicz","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2019.01.020_bib11","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.hrthm.2015.04.029","article-title":"Characterization of ventricular activation pattern and acute hemodynamics during multipoint left ventricular pacing","volume":"12","author":"Menardi","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2019.01.020_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ccep.2014.11.012","article-title":"Noninvasive mapping of electrical dyssynchrony in heart failure and cardiac resynchronization therapy","volume":"7","author":"Varma","year":"2015","journal-title":"Card Electrophysiol Clin"},{"key":"10.1016\/j.hrthm.2019.01.020_bib13","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/pace.13118","article-title":"The concept of triple wavefront fusion during biventricular pacing: using the EGM to produce the best acute hemodynamic improvement in CRT","volume":"40","author":"Ter Horst","year":"2017","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.01.020_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jacep.2017.11.020","article-title":"Improvement of reverse remodeling using ECG fusion-optimized intervals in cardiac resynchronization therapy: a randomized study","volume":"4","author":"Trucco","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.01.020_bib15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1540-8159.2010.03022.x","article-title":"The QRS narrowing index predicts reverse left ventricular remodeling following cardiac resynchronization therapy","volume":"34","author":"Rickard","year":"2011","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.01.020_bib16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1540-8159.2004.00433.x","article-title":"QRS duration and shortening to predict clinical response to cardiac resynchronization therapy in patients with end-stage heart failure","volume":"27","author":"Molhoek","year":"2004","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.01.020_bib17","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.hrthm.2012.07.009","article-title":"Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: results of the adaptive CRT trial","volume":"9","author":"Martin","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2019.01.020_bib18","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.hrthm.2013.07.007","article-title":"Clinical outcomes with synchronized left ventricular pacing: analysis of the adaptive CRT trial","volume":"10","author":"Birnie","year":"2013","journal-title":"Heart Rhythm"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527119300335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527119300335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T20:29:27Z","timestamp":1569356967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527119300335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1547527119300335"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2019.01.020","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic programming of atrioventricular delay improves electrical synchrony in a multicenter cardiac resynchronization therapy study","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2019.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier Inc. on behalf of Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}