{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:57:35Z","timestamp":1772171855229,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.hrthm.2019.11.019","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T12:20:17Z","timestamp":1574166017000},"page":"637-645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["New electromechanical substrate abnormalities in high-risk patients with Brugada syndrome"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-6135","authenticated-orcid":false,"given":"Carlo","family":"Pappone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Mecarocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Manguso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-5467","authenticated-orcid":false,"given":"Giuseppe","family":"Ciconte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Vicedomini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-304X","authenticated-orcid":false,"given":"Francesco","family":"Sturla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Votta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beniamino","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Anastasia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Micaglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-0455","authenticated-orcid":false,"given":"Emanuela","family":"Locati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Monasky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarko","family":"Calovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Santinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2019.11.019_bib1","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1016\/j.hrthm.2016.05.024","article-title":"J-wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge","volume":"13","author":"Antzelevitch","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2019.11.019_bib2","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/CIRCULATIONAHA.106.628537","article-title":"Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study","volume":"114","author":"Sacher","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2019.11.019_bib3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/CIRCULATIONAHA.110.972612","article-title":"Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium","volume":"123","author":"Nademanee","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2019.11.019_bib4","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/CIRCEP.115.003220","article-title":"Brugada syndrome phenotype elimination by epicardial substrate ablation","volume":"8","author":"Brugada","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005053","article-title":"Electrical substrate elimination in 135 consecutive patients with Brugada syndrome","volume":"10","author":"Pappone","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib6","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jacc.2018.02.022","article-title":"Assessing the malignant arrhythmic substrate in patients with Brugada syndrome","volume":"71","author":"Pappone","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib7","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1161\/CIRCULATIONAHA.105.532614","article-title":"Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study","volume":"112","author":"Coronel","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2019.11.019_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0735-1097(95)00485-8","article-title":"Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death","volume":"27","author":"Corrado","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1053\/euhj.2000.2424","article-title":"Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome","volume":"22","author":"Takagi","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2019.11.019_bib10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1046\/j.1540-8167.2004.03681.x","article-title":"Magnetic resonance imaging findings in patients with Brugada syndrome","volume":"15","author":"Papavassiliu","year":"2004","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-7120-9-30","article-title":"Right ventricular dysfunction in patients with Brugada-like electrocardiography: a two dimensional strain imaging study","volume":"9","author":"Murata","year":"2011","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.hrthm.2019.11.019_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.hrthm.2009.10.007","article-title":"Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch","volume":"7","author":"Hoogendijk","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2019.11.019_bib13","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1093\/eurheartj\/ehp252","article-title":"Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities","volume":"30","author":"Catalano","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2019.11.019_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijcard.2019.06.074","article-title":"Contraction alterations in Brugada syndrome; association with life-threatening ventricular arrhythmias","volume":"299","author":"Scheirlynck","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib15","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.jacc.2015.08.862","article-title":"Fibrosis, connexin-43, and conduction abnormalities in the Brugada syndrome","volume":"66","author":"Nademanee","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib16","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.jacc.2018.09.037","article-title":"Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada syndrome","volume":"72","author":"Pieroni","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042037","article-title":"SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility","volume":"7","author":"van Hoorn","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2019.11.019_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.hrthm.2016.12.004","article-title":"Late gadolinium enhancement in Brugada syndrome: a marker for subtle underlying cardiomyopathy?","volume":"14","author":"Bastiaenen","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2019.11.019_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195594","article-title":"Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada syndrome","volume":"13","author":"Gray","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2019.11.019_bib20","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s10554-012-0009-5","article-title":"Evaluation of Brugada syndrome by cardiac magnetic resonance","volume":"28","author":"Tessa","year":"2012","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2019.11.019_bib21","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.hrthm.2010.09.004","article-title":"Spontaneous type 1 electrocardiographic pattern is associated with cardiovascular magnetic resonance imaging changes in Brugada syndrome","volume":"7","author":"Papavassiliu","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2019.11.019_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adult: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2019.11.019_bib23","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s10554-017-1199-7","article-title":"Clinical feasibility and validation of 3D principal strain analysis from cine MRI: comparison to 2D strain by MRI and 3D speckle tracking echocardiography","volume":"33","author":"Satriano","year":"2017","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2019.11.019_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4250\/jcu.2014.22.3.113","article-title":"Validation of global longitudinal strain and strain rate as reliable markers of right ventricular dysfunction: comparison with cardiac magnetic resonance and outcome","volume":"22","author":"Park","year":"2014","journal-title":"J Cardiovasc Ultrasound"},{"key":"10.1016\/j.hrthm.2019.11.019_bib25","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/ehjci\/jev309","article-title":"New speckle-tracking algorithm for right ventricular volume analysis from three-dimensional echocardiographic data sets: validation with cardiac magnetic resonance and comparison with the previous analysis tool","volume":"17","author":"Muraru","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2019.11.019_bib26","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1001\/jamacardio.2019.2424","article-title":"New directions in right ventricular assessment using 3-dimensional echocardiography","volume":"4","author":"Addetia","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib27","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.echo.2018.11.014","article-title":"Comparison between four-chamber and right ventricular-focused views for the quantitative evaluation of right ventricular size and function","volume":"32","author":"Genovese","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.hrthm.2019.11.019_bib28","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.jacc.2016.08.061","article-title":"Right ventricular imaging and computer simulation for electromechanical substrate characterization in arrhythmogenic right ventricular cardiomyopathy","volume":"68","author":"Mast","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib29","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/ehjci\/jex163","article-title":"Three-dimensional right-ventricular regional deformation and survival in pulmonary hypertension","volume":"19","author":"Moceri","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2019.11.019_bib30","doi-asserted-by":"crossref","first-page":"H279","DOI":"10.1152\/ajpheart.00079.2010","article-title":"Ionic mechanisms of cellular electrical and mechanical abnormalities in Brugada syndrome","volume":"300","author":"Dong","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2019.11.019_bib31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1161\/CIRCEP.110.937029","article-title":"The Brugada ECG pattern: a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome","volume":"3","author":"Hoogendijk","year":"2010","journal-title":"Circ Arrhyth Electrophysiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527119310318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527119310318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:49:46Z","timestamp":1761547786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527119310318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1547527119310318"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2019.11.019","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New electromechanical substrate abnormalities in high-risk patients with Brugada syndrome","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2019.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc. on behalf of Heart Rhythm Society.","name":"copyright","label":"Copyright"}]}}