{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:34:00Z","timestamp":1791549240037,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.hrthm.2020.02.007","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T23:55:32Z","timestamp":1581724532000},"page":"1025-1033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Mechanisms of atrial fibrillation in aged rats with heart failure with preserved ejection fraction"],"prefix":"10.1016","volume":"17","author":[{"given":"Thassio Ricardo Ribeiro","family":"Mesquita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"de Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackelyn","family":"Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbeth","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell G.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Marb\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Cingolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2020.02.007_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jchf.2018.05.005","article-title":"Atrial fibrillation in heart failure with preserved ejection fraction: the TOPCAT trial","volume":"6","author":"Cikes","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.hrthm.2020.02.007_bib2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/CIRCULATIONAHA.113.001475","article-title":"Temporal relationship and prognostic significance of atrial fibrillation in heart failure patients with preserved ejection fraction: a community-based study","volume":"128","author":"Zakeri","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2020.02.007_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrcardio.2017.65","article-title":"Epidemiology of heart failure with preserved ejection fraction","volume":"14","author":"Dunlay","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0735-1097(02)02696-7","article-title":"Gender, age, and heart failure with preserved left ventricular systolic function","volume":"41","author":"Masoudi","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.115.302922","article-title":"Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies","volume":"115","author":"Sharma","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2020.02.007_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121123","article-title":"Reverse electrical remodeling in rats with heart failure and preserved ejection fraction","volume":"3","author":"Cho","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.hrthm.2020.02.007_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jacbts.2016.01.003","article-title":"Cardiosphere-derived cells reverse heart failure with preserved ejection fraction (HFpEF) in rats by decreasing fibrosis and inflammation","volume":"1","author":"Gallet","year":"2016","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.hrthm.2020.02.007_bib8","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jacc.2017.08.074","article-title":"Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes","volume":"70","author":"Shah","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib9","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/CIRCULATIONAHA.117.028202","article-title":"Delayed repolarization underlies ventricular arrhythmias in rats with heart failure and preserved ejection fraction","volume":"136","author":"Cho","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2020.02.007_bib10","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/CIRCULATIONAHA.118.035202","article-title":"Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation","volume":"138","author":"Yao","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2020.02.007_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J Exp Med"},{"key":"10.1016\/j.hrthm.2020.02.007_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006416","article-title":"Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction","volume":"6","author":"Bowen","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2020.02.007_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/CIRCHEARTFAILURE.109.931451","article-title":"Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction","volume":"4","author":"Westermann","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.hrthm.2020.02.007_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cardfail.2014.11.004","article-title":"Exaggerated inflammation and monocytosis associate with diastolic dysfunction in heart failure with preserved ejection fraction: evidence of M2 macrophage activation in disease pathogenesis","volume":"21","author":"Glezeva","year":"2015","journal-title":"J Card Fail"},{"key":"10.1016\/j.hrthm.2020.02.007_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCEP.107.754564","article-title":"Atrial remodeling and atrial fibrillation: mechanisms and implications","volume":"1","author":"Nattel","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cardiores.2007.01.020","article-title":"Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes","volume":"74","author":"Yeh","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"55","key":"10.1016\/j.hrthm.2020.02.007_bib17","doi-asserted-by":"crossref","DOI":"10.3791\/3275","article-title":"Optical mapping of action potentials and calcium transients in the mouse heart","author":"Lang","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1016\/j.hrthm.2020.02.007_bib18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jacc.2018.11.033","article-title":"Heart failure with preserved ejection fraction and diabetes: JACC State-of-the-Art Review","volume":"73","author":"McHugh","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib19","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/eurheartj\/ehx454","article-title":"Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats","volume":"38","author":"Grigorian-Shamagian","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2020.02.007_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41569-018-0061-5","article-title":"Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence","volume":"15","author":"Gude","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib21","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/CIRCULATIONAHA.114.013215","article-title":"Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin","volume":"131","author":"Zile","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2020.02.007_bib22","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1113\/JP277479","article-title":"Unmasking of oestrogen-dependent changes in left ventricular structure and function in aged female rats: a potential model for pre-heart failure with preserved ejection fraction","volume":"597","author":"Bustamante","year":"2019","journal-title":"J Physiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1046\/j.1540-8167.2002.00801.x","article-title":"Aging-related increase to inducible atrial fibrillation in the rat model","volume":"13","author":"Hayashi","year":"2002","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.118.006452","article-title":"Ventricular arrhythmias underlie sudden death in rats with heart failure and preserved ejection fraction","volume":"11","author":"Cho","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/CIRCHEARTFAILURE.112.970061","article-title":"Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial","volume":"5","author":"Lam","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.hrthm.2020.02.007_bib26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/pace.12037","article-title":"Prolonged atrial effective refractory periods in atrial fibrillation patients associated with structural heart disease or sinus node dysfunction compared with lone atrial fibrillation","volume":"36","author":"Uhm","year":"2013","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2020.02.007_bib29","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.hrthm.2020.02.007_bib30","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0008-6363(01)00380-7","article-title":"The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation","volume":"52","author":"Workman","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2020.02.007_bib31","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/jcmm.12084","article-title":"Age-related changes in cellular electrophysiology and calcium handling for atrial fibrillation","volume":"17","author":"Xu","year":"2013","journal-title":"J Cell Mol Med"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527120301090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527120301090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:50:35Z","timestamp":1761547835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527120301090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1547527120301090"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2020.02.007","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of atrial fibrillation in aged rats with heart failure with preserved ejection fraction","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2020.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}