{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:40:17Z","timestamp":1790523617025,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 1666105"],"award-info":[{"award-number":["PJT 1666105"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.hrthm.2020.03.014","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T02:59:40Z","timestamp":1585277980000},"page":"1360-1370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Altered heart rate variability in angiotensin II\u2013mediated hypertension is associated with impaired autonomic nervous system signaling and intrinsic sinoatrial node dysfunction"],"prefix":"10.1016","volume":"17","author":[{"given":"Tristan W.","family":"Dorey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahareh","family":"Moghtadaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2020.03.014_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/physrev.00018.2007","article-title":"Genesis and regulation of the heart automaticity","volume":"88","author":"Mangoni","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.hrthm.2020.03.014_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fphys.2011.00086","article-title":"Heart rate variability\u2014a historical perspective","volume":"2","author":"Billman","year":"2011","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib3","article-title":"Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease","volume":"4","author":"Yaniv","year":"2014","journal-title":"J Clin Trials"},{"key":"10.1016\/j.hrthm.2020.03.014_bib4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/europace\/eus341","article-title":"Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression","volume":"15","author":"Hillebrand","year":"2013","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2020.03.014_bib5","first-page":"82","article-title":"Intracardiac origin of heart rate variability, pacemaker funny current and their possible association with critical illness","volume":"9","author":"Papaioannou","year":"2013","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.hrthm.2020.03.014_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jacc.2014.03.056","article-title":"Incidence of and risk factors for sick sinus syndrome in the general population","volume":"64","author":"Jensen","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jacbts.2018.08.004","article-title":"Natriuretic peptide receptor-C protects against angiotensin II-mediated sinoatrial node disease in mice","volume":"3","author":"Mackasey","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.hrthm.2020.03.014_bib8","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/01.HYP.0000100444.71069.73","article-title":"Hypertension, blood pressure, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) study","volume":"42","author":"Schroeder","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.hrthm.2020.03.014_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.jhh.1001529","article-title":"Reduced heart rate variability in hypertension: associations with lifestyle factors and plasma renin activity","volume":"17","author":"Virtanen","year":"2003","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.hrthm.2020.03.014_bib10","doi-asserted-by":"crossref","first-page":"17564","DOI":"10.1038\/s41598-017-17690-7","article-title":"Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C)","volume":"7","author":"Moghtadaei","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.hrthm.2020.03.014_bib11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1113\/jphysiol.2013.265405","article-title":"Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart","volume":"592","author":"Azer","year":"2014","journal-title":"J Physiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib12","doi-asserted-by":"crossref","first-page":"H1970","DOI":"10.1152\/ajpheart.00893.2003","article-title":"Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor","volume":"286","author":"Rose","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijcard.2009.09.543","article-title":"The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors","volume":"141","author":"Thayer","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib14","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1161\/CIRCRESAHA.114.302524","article-title":"The autonomic nervous system and hypertension","volume":"114","author":"Mancia","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2020.03.014_bib15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/eci.12553","article-title":"Sympathetic activation in cardiovascular disease: evidence, clinical impact and therapeutic implications","volume":"45","author":"Grassi","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.hrthm.2020.03.014_bib16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/01.HYP.29.3.715","article-title":"The cardiac beta-adrenoceptor-mediated signaling pathway and its alterations in hypertensive heart disease","volume":"29","author":"Castellano","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.hrthm.2020.03.014_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1752-8062.2008.00050.x","article-title":"Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients","volume":"1","author":"Izzo","year":"2008","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.hrthm.2020.03.014_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nprot.2015.139","article-title":"Comprehensive multilevel in\u00a0vivo and in\u00a0vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology","volume":"11","author":"Fenske","year":"2016","journal-title":"Nat Protoc"},{"key":"10.1016\/j.hrthm.2020.03.014_bib19","doi-asserted-by":"crossref","first-page":"H1632","DOI":"10.1152\/ajpheart.01051.2002","article-title":"Mechanisms of altered vagal control in heart failure: influence of muscarinic receptors and acetylcholinesterase activity","volume":"285","author":"Dunlap","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib20","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/CIRCULATIONAHA.107.760405","article-title":"Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy","volume":"118","author":"Olshansky","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2020.03.014_bib21","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.hrthm.2015.03.025","article-title":"Subcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction","volume":"12","author":"Chan","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2020.03.014_bib22","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.hrthm.2009.01.006","article-title":"Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure","volume":"6","author":"Piccirillo","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2020.03.014_bib23","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/ejhf.921","article-title":"The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology","volume":"19","author":"van Bilsen","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.hrthm.2020.03.014_bib24","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/acel.12483","article-title":"Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in\u00a0vivo","volume":"15","author":"Yaniv","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.hrthm.2020.03.014_bib25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1161\/HYPERTENSIONAHA.111.173104","article-title":"Role of elevated heart rate in the development of cardiovascular disease in hypertension","volume":"58","author":"Palatini","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.hrthm.2020.03.014_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fphys.2015.00037","article-title":"Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction","volume":"6","author":"Csepe","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib27","doi-asserted-by":"crossref","first-page":"H2076","DOI":"10.1152\/ajpheart.00917.2001","article-title":"Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice","volume":"282","author":"Shusterman","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2020.03.014_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/cvr\/cvq111","article-title":"Genetic background affects function and intracellular calcium regulation of mouse hearts","volume":"87","author":"Shah","year":"2010","journal-title":"Cardiovasc Res"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527120302563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527120302563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:17:12Z","timestamp":1778818632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527120302563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1547527120302563"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2020.03.014","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered heart rate variability in angiotensin II\u2013mediated hypertension is associated with impaired autonomic nervous system signaling and intrinsic sinoatrial node dysfunction","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2020.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}