{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:08:24Z","timestamp":1785298104916,"version":"3.55.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.hrthm.2021.09.028","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T15:10:59Z","timestamp":1633014659000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sinus rhythm QRS amplitude and fractionation in patients with nonischemic cardiomyopathy to identify ventricular tachycardia substrate and location"],"prefix":"10.1016","volume":"19","author":[{"given":"Mart\u00edn R.","family":"Arceluz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Liuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory M.","family":"Tschabrunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Supple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin C.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Callans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo S.","family":"Guandalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Zado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2021.09.028_bib1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/0002-9149(87)90618-7","article-title":"Idiopathic dilated cardiomyopathy: analysis of 152 necropsy patients","volume":"60","author":"Roberts","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0002-9149(86)90620-X","article-title":"Extent of myocardial fibrosis and cellular hypertrophy in dilated cardiomyopathy","volume":"57","author":"Unverferth","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib3","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1161\/01.CIR.0000083725.72693.EA","article-title":"Characterization of endocardial electrophysiological substrate in patients with nonischemic cardiomyopathy and monomorphic ventricular tachycardia","volume":"108","author":"Hsia","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2021.09.028_bib4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/CIRCEP.114.001568","article-title":"Catheter ablation of ventricular arrhythmia in non-ischemic cardiomyopathy anteroseptal versus inferolateral scar sub-types","volume":"7","author":"Oloriz","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10840-017-0228-8","article-title":"Cardiac magnetic resonance imaging and electroanatomic voltage discordance in non-ischemic left ventricular tachycardia and premature ventricular depolarizations","volume":"49","author":"Betensky","year":"2017","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.hrthm.2011.03.008","article-title":"Isolated septal substrate for ventricular tachycardia in nonischemic dilated cardiomyopathy: incidence, characterization, and implications","volume":"8","author":"Haqqani","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2021.09.028_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/CIRCEP.113.000089","article-title":"Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in non-ischemic cardiomyopathy: implications for the ablation strategy","volume":"6","author":"Piers","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10840-012-9709-y","article-title":"Sinus rhythm electrocardiogram identification of basal-lateral ischemic versus non-ischemic substrate in patientswithventricular tachycardia","volume":"35","author":"Betensky","year":"2012","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib9","first-page":"1850","article-title":"The value of the 12-lead electrocardiogram in localizing the scar in non-ischaemic cardiomyopathy","volume":"18","author":"Oloriz","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2021.09.028_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCEP.110.959957","article-title":"Endocardial unipolar voltage mapping to detect epicardial ventricular tachycardia substrate in patients with non-ischemic left ventricular cardiomyopathy","volume":"4","author":"Hutchinson","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.hrthm.2009.09.065","article-title":"Fragmented QRS on twelve-lead electrocardiogram predicts arrhythmic events in patients with ischemic and non-ischemic cardiomyopathy","volume":"7","author":"Das","year":"2010","journal-title":"Heart Rhythm"},{"issue":"3 Suppl","key":"10.1016\/j.hrthm.2021.09.028_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.hrthm.2008.10.019","article-title":"Fragmented QRS: a predictor of mortality and sudden cardiac death","volume":"6","author":"Das","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2021.09.028_bib13","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/CIRCEP.113.000682","article-title":"Characterization of trans-septal activation during septal pacing: criteria for identification of intramural ventricular tachycardia substrate in nonischemic cardiomyopathy","volume":"6","author":"Betensky","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib14","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.hrthm.2007.07.004","article-title":"Site-specific twelve-lead ECG features to identify an epicardial origin for left ventricular tachycardia in the absence of myocardial infarction","volume":"4","author":"Bazan","year":"2007","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2021.09.028_bib15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jacc.2009.05.032","article-title":"Electroanatomic substrate and ablation outcome for suspected epicardial ventricular tachycardia in left ventricular non-ischemic cardiomyopathy","volume":"54","author":"Cano","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jacep.2017.01.009","article-title":"12-Lead electrocardiogram to localize region of abnormal electroanatomic substrate in arrhythmogenicrightventricular cardiomyopathy","volume":"3","author":"Tschabrunn","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.hlc.2018.10.007","article-title":"Catheter ablation of VT in Non-ischaemic cardiomyopathies: endocardial, epicardial and intramural approaches","volume":"28","author":"Bhaskaran","year":"2019","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.hrthm.2021.09.028_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jelectrocard.2007.12.001","article-title":"Electrocardiogram voltage discordance: interpretation of low QRS voltage only in the limb leads","volume":"4","author":"Chinitz","year":"2008","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.hrthm.2021.09.028_bib19","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1161\/CIRCULATIONAHA.105.595892","article-title":"Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease","volume":"113","author":"Das","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2021.09.028_bib20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1136\/heartjnl-2019-316105","article-title":"Electrocardiographic associations with myocardial fibrosis among sudden cardiac death victims","volume":"106","author":"Holmstr\u00f6m","year":"2020","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2021.09.028_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.amjcard.2014.03.066","article-title":"Prevalence and prognostic significance of fragmented QRS complex in middle-aged subjects with and without clinical or electrocardiographic evidence of cardiac disease","volume":"114","author":"Terho","year":"2014","journal-title":"Am J Cardiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527121022049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527121022049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:55:19Z","timestamp":1761548119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527121022049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S1547527121022049"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2021.09.028","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sinus rhythm QRS amplitude and fractionation in patients with nonischemic cardiomyopathy to identify ventricular tachycardia substrate and location","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2021.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}