{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:25:35Z","timestamp":1785860735609,"version":"3.56.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.hrthm.2021.09.032","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T03:45:36Z","timestamp":1633059936000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["High-density epicardial mapping in Brugada syndrome: Depolarization and repolarization abnormalities"],"prefix":"10.1016","volume":"19","author":[{"given":"Luigi","family":"Pannone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sorgente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Adrian","family":"Calburean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Gauthey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bisignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Kazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antanas","family":"Strazdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerelle","family":"Mojica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Lipartiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysam","family":"Al Housari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Miraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Sofianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Cecchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Guimar\u00e3es","family":"Os\u00f3rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Paparella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert","family":"Ramak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Overeinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gezim","family":"Bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Almorad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Str\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Pappaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"La Meir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Battista","family":"Chierchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2021.09.032_bib1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib2","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.jacc.2018.09.037","article-title":"Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada syndrome","volume":"72","author":"Pieroni","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib3","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.jacc.2015.08.862","article-title":"Fibrosis, connexin-43, and conduction abnormalities in the Brugada syndrome","volume":"66","author":"Nademanee","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib4","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/CIRCULATIONAHA.110.972612","article-title":"Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium","volume":"123","author":"Nademanee","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2021.09.032_bib5","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.jacc.2014.01.067","article-title":"Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome","volume":"63","author":"Sz\u00e9l","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.yjmcc.2010.07.012","article-title":"The pathophysiological mechanism underlying Brugada syndrome. Depolarization versus repolarization","volume":"49","author":"Wilde","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib7","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1161\/CIRCULATIONAHA.114.013698","article-title":"Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients","volume":"131","author":"Zhang","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2021.09.032_bib8","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2021.09.032_bib9","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1093\/eurheartj\/ehx119","article-title":"A score model to predict risk of events in patients with Brugada syndrome","volume":"38","author":"Sieira","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2021.09.032_bib10","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.hrthm.2018.12.026","article-title":"Hybrid thoracoscopic epicardial ablation of right ventricular outflow tract in patients with Brugada syndrome","volume":"16","author":"Salghetti","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2021.09.032_bib11","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1161\/CIRCULATIONAHA.111.043216","article-title":"Elimination of local abnormal ventricular activities: a new end point for substrate modification in patients with scar-related ventricular tachycardia","volume":"125","author":"Ja\u00efs","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2021.09.032_bib12","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jacc.2018.06.037","article-title":"Present status of Brugada syndrome: JACC state-of-the-art review","volume":"72","author":"Brugada","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib13","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1161\/CIRCULATIONAHA.105.520999","article-title":"Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome","volume":"112","author":"Frustaci","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2021.09.032_bib14","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/S0735-1097(02)01888-0","article-title":"Epicardial electrogram of the right ventricular outflow tract in patients with the Brugada syndrome: using the epicardial lead","volume":"39","author":"Nagase","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jacep.2018.08.022","article-title":"Detailed analysis of the relation between bipolar electrode spacing and far- and near-field electrograms","volume":"5","author":"Takigawa","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jacep.2016.10.011","article-title":"Mechanisms underlying epicardial radiofrequency ablation to suppress arrhythmogenesis in experimental models of Brugada syndrome","volume":"3","author":"Patocskai","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0735-1097(02)01964-2","article-title":"The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome","volume":"40","author":"Kurita","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005775","article-title":"Ajmaline-induced slowing of conduction in the right ventricular outflow tract cannot account for ST elevation in patients with Type I Brugada ECG","volume":"10","author":"Antzelevitch","year":"2017","journal-title":"Circ Arrhythmia Electrophysiol"},{"key":"10.1016\/j.hrthm.2021.09.032_bib19","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1016\/j.jacc.2005.12.064","article-title":"Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model. High-resolution optical mapping study","volume":"47","author":"Aiba","year":"2006","journal-title":"J Am Coll Cardiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527121022086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527121022086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:56:29Z","timestamp":1761548189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527121022086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1547527121022086"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2021.09.032","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-density epicardial mapping in Brugada syndrome: Depolarization and repolarization abnormalities","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2021.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}