{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:11:53Z","timestamp":1786990313956,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.hrthm.2023.01.021","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T11:24:56Z","timestamp":1674300296000},"page":"730-736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure"],"prefix":"10.1016","volume":"20","author":[{"given":"Gyeoung-Jin","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Samuel C.","family":"Dudley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2023.01.021_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bmb\/59.1.193","article-title":"Ischaemic heart disease presenting as arrhythmias","volume":"59","author":"Ghuran","year":"2001","journal-title":"Br Med Bull"},{"key":"10.1016\/j.hrthm.2023.01.021_bib2","first-page":"192","article-title":"Cardiac arrhythmias during myocardial infarction","volume":"28","author":"Glancy","year":"2015","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"10.1016\/j.hrthm.2023.01.021_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140759","article-title":"MIR448 antagomir reduces arrhythmic risk after myocardial infarction by upregulating the cardiac sodium channel","volume":"5","author":"Kang","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.hrthm.2023.01.021_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007802","article-title":"RNA binding protein, HuR, regulates SCN5A expression through stabilizing MEF2C transcription factor mRNA","volume":"7","author":"Zhou","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2023.01.021_bib5","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.hrthm.2018.02.018","article-title":"HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure","volume":"15","author":"Zhou","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2023.01.021_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tcm.2012.08.003","article-title":"RBM25\/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure","volume":"23","author":"Gao","year":"2013","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.hrthm.2023.01.021_bib7","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1161\/CIRCRESAHA.107.152918","article-title":"Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel","volume":"101","author":"Shang","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2023.01.021_bib8","doi-asserted-by":"crossref","first-page":"15629","DOI":"10.1074\/jbc.271.26.15629","article-title":"Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene","volume":"271","author":"Wymore","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.hrthm.2023.01.021_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/geno.1994.1153","article-title":"Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4\/Kv1.4 to mouse chromosome 2\/human 11p14 and mapping of KCNC1\/Kv3.1 to mouse 7\/human 11p14.3-p15.2 and KCNA1\/Kv1.1 to human 12p13","volume":"20","author":"Wymore","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.hrthm.2023.01.021_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.672360","article-title":"Three-week-old rabbit ventricular cardiomyocytes as a novel system to study cardiac excitation and EC coupling","volume":"12","author":"Kabakov","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib11","doi-asserted-by":"crossref","first-page":"H461","DOI":"10.1152\/ajpheart.00256.2021","article-title":"Voltage-gated potassium channel dysfunction in dorsal root ganglia contributes to the exaggerated exercise pressor reflex in rats with chronic heart failure","volume":"321","author":"Hong","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yjmcc.2019.09.013","article-title":"Metabolic regulation of Kv channels and cardiac repolarization by Kv\u03b22 subunits","volume":"137","author":"Kilfoil","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib13","first-page":"H1599","article-title":"Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle","volume":"276","author":"Wickenden","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1469-7793.1998.171bo.x","article-title":"The transient outward current in mice lacking the potassium channel gene Kv1.4","volume":"509","author":"London","year":"1998","journal-title":"J Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/01.RES.79.4.659","article-title":"Role of the Kv4.3 K+ channel in ventricular muscle: a molecular correlate for the transient outward current","volume":"79","author":"Dixon","year":"1996","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2023.01.021_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1096\/fasebj.5.3.2001794","article-title":"Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle","volume":"5","author":"Tamkun","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.hrthm.2023.01.021_bib17","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/cdd.2017.51","article-title":"Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties","volume":"24","author":"Mahrouf-Yorgov","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.hrthm.2023.01.021_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229158","article-title":"Development of endomyocardial fibrosis model using a cell patterning technique: in\u00a0vitro interaction of cell coculture of 3T3 fibroblasts and RL-14 cardiomyocytes","volume":"15","author":"Orozco","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2023.01.021_bib19","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.xphs.2020.03.016","article-title":"Fluconazole represses cytochrome P450 1B1 and its associated arachidonic acid metabolites in the heart and protects against angiotensin II-induced cardiac hypertrophy","volume":"109","author":"Alammari","year":"2020","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.hrthm.2023.01.021_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200448","article-title":"Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes","volume":"13","author":"Xie","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2023.01.021_bib21","doi-asserted-by":"crossref","first-page":"H2006","DOI":"10.1152\/ajpheart.00694.2011","article-title":"High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents","volume":"301","author":"Ma","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1573403X12666160301120217","article-title":"Drug-induced inhibition and trafficking disruption of ion channels: pathogenesis of QT abnormalities and drug-induced fatal arrhythmias","volume":"12","author":"Cubeddu","year":"2016","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.hrthm.2023.01.021_bib23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/CIRCEP.113.000239","article-title":"Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome","volume":"6","author":"Veerman","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib24","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.jcmg.2019.10.021","article-title":"Sudden cardiac death in ischemic heart disease: from imaging arrhythmogenic substrate to guiding therapies","volume":"13","author":"Gr\u00e4ni","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2023.01.021_bib25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fphys.2013.00254","article-title":"Identifying potential functional impact of mutations and polymorphisms: linking heart failure, increased risk of arrhythmias and sudden cardiac death","volume":"4","author":"Jagu","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147836","article-title":"Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction","volume":"131","author":"Liu","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.hrthm.2023.01.021_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206239","article-title":"miRWalk: an online resource for prediction of microRNA binding sites","volume":"13","author":"Sticht","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2023.01.021_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jneuroim.2005.08.017","article-title":"Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis","volume":"170","author":"Suzuki","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib29","doi-asserted-by":"crossref","first-page":"jcs256818","DOI":"10.1242\/jcs.256818","article-title":"Nucleoporin 50 mediates KCNA4 transcription to regulate cardiac electrical activity","volume":"134","author":"Gao","year":"2021","journal-title":"J Cell Sci"},{"key":"10.1016\/j.hrthm.2023.01.021_bib30","doi-asserted-by":"crossref","first-page":"H1800","DOI":"10.1152\/ajpheart.2001.281.4.H1800","article-title":"Altered K+ channel gene expression in diabetic rat ventricle: isoform switching between Kv4.2 and Kv1.4","volume":"281","author":"Nishiyama","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrthm.2023.01.021_bib31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/01.RES.75.2.252","article-title":"Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats","volume":"75","author":"Dixon","year":"1994","journal-title":"Circ Res"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527123001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527123001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:58:09Z","timestamp":1761548289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527123001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1547527123001030"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2023.01.021","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2023.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}