{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:29:33Z","timestamp":1793917773718,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.hrthm.2023.06.007","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T18:59:06Z","timestamp":1686855546000},"page":"1279-1286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Clinical impact of aging on outcomes of cardioneuroablation for reflex syncope or functional bradycardia: Results from the cardionEuroabLation: patiEnt selection, imaGe integrAtioN and outComEs\u2014The ELEGANCE multicenter study"],"prefix":"10.1016","volume":"20","author":[{"given":"Pietro","family":"Francia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Viveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Falasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Penela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Soto-Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Mart\u00ed-Almor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Alderete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Saglietto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Francisco","family":"Bellido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Franco-Oca\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Zaraket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Matiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fern\u00e1ndez-Armenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"San Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-383X","authenticated-orcid":false,"given":"Antonio","family":"Berruezo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2023.06.007_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/europace\/eur163","article-title":"Catheter ablation of severe neurally meditated reflex (neurocardiogenic or vasovagal) syncope: cardioneuroablation long-term results","volume":"13","author":"Pachon","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2023.06.007_bib2","doi-asserted-by":"crossref","unstructured":"Vandenberk B, Lei LY, Ballantyne B, et\u00a0al. Cardioneuroablation for vasovagal syncope: a systematic review and meta-analysis. Heart Rhythm Jun 16 2022. https:\/\/doi.org\/10.1016\/j.hrthm.2022.06.017.","DOI":"10.1016\/j.hrthm.2022.06.017"},{"key":"10.1016\/j.hrthm.2023.06.007_bib3","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.hrthm.2019.08.008","article-title":"Cardioneuroablation for neurocardiogenic syncope","volume":"16","author":"Pachon","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2023.06.007_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jacep.2022.08.011","article-title":"Cardioneuroablation for reflex syncope: efficacy and effects on autonomic cardiac regulation\u2014a prospective randomized trial","volume":"9","author":"Piotrowski","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib5","doi-asserted-by":"crossref","unstructured":"Francia P, Viveros D, Falasconi G, et\u00a0al. Cardioneuroablation for carotid sinus syndrome: a case series. Heart Rhythm Jan 09 2023. https:\/\/doi.org\/10.1016\/j.hrthm.2023.01.003.","DOI":"10.1016\/j.hrthm.2023.01.003"},{"key":"10.1016\/j.hrthm.2023.06.007_bib6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jacep.2017.01.022","article-title":"Atrial Ganglionated plexus modification: a novel approach to treat symptomatic sinus bradycardia","volume":"3","author":"Qin","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.121.010018","article-title":"Cardioneuroablation for treatment of atrioventricular block","volume":"14","author":"Aksu","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib8","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/jce.15480","article-title":"Cardioneuroablation for vasovagal syncope and atrioventricular block: a step-by-step guide","volume":"33","author":"Aksu","year":"2022","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10840-015-9981-8","article-title":"Atrial autonomic denervation for the treatment of long-standing symptomatic sinus bradycardia in non-elderly patients","volume":"43","author":"Zhao","year":"2015","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/oxfordjournals.eurheartj.a062120","article-title":"Variations of normal sinus node function in relation to age: role of autonomic influence","volume":"7","author":"De Marneffe","year":"1986","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2023.06.007_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fphys.2015.00037","article-title":"Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction","volume":"6","author":"Csepe","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1088881","article-title":"Selection of patients with symptomatic vagal-induced sinus node dysfunction: who will be the best candidate for cardioneuroablation?","volume":"14","author":"Cai","year":"2023","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib13","article-title":"Pacing or ablation for vasovagal syncope: one size does not fit all","volume":"11","author":"Aksu","year":"2023","journal-title":"Eur Heart J Apr"},{"key":"10.1016\/j.hrthm.2023.06.007_bib14","doi-asserted-by":"crossref","unstructured":"Brignole M, Aksu T, Cal\u00f2 L, et\u00a0al. Clinical controversy: methodology and indications of cardioneuroablation for reflex syncope. Europace Apr 06 2023. https:\/\/doi.org\/10.1093\/europace\/euad033.","DOI":"10.1093\/europace\/euad033"},{"key":"10.1016\/j.hrthm.2023.06.007_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/eupc.1999.0064","article-title":"New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study","volume":"2","author":"Brignole","year":"2000","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2023.06.007_bib16","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1111\/jce.15038","article-title":"The anatomical basis behind the neuromodulation effects associated with pulmonary vein isolation","volume":"32","author":"Aksu","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib17","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/europace\/euab024","article-title":"Age-related tilt test responses in patients with suspected reflex syncope","volume":"23","author":"Rivasi","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2023.06.007_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10286-015-0310-1","article-title":"Sex and age effects on cardiovascular autonomic function in healthy adults","volume":"25","author":"Ndayisaba","year":"2015","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.hrthm.2023.06.007_bib19","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/hc4501.099308","article-title":"Altered autonomic support of arterial blood pressure with age in healthy men","volume":"104","author":"Jones","year":"2001","journal-title":"Circulation"},{"issue":"4 Pt 2","key":"10.1016\/j.hrthm.2023.06.007_bib20","first-page":"H1441","article-title":"Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans","volume":"268","author":"Craft","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.autneu.2008.01.007","article-title":"Effects of fitness and age on the response to vagotonic atropine","volume":"139","author":"Lee","year":"2008","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.hrthm.2023.06.007_bib22","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.hrthm.2019.07.018","article-title":"Right anterior ganglionated plexus: the primary target of cardioneuroablation?","volume":"16","author":"Hu","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2023.06.007_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.009747","article-title":"Durable physiological changes and decreased syncope burden 12 months after unifocal right-sided ablation under computed tomographic guidance in patients with neurally mediated syncope or functional sinus node dysfunction","volume":"14","author":"Debruyne","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2021.102838","article-title":"Cardioneuroablation changes the type of vasovagal response in patients with asystolic reflex syncope","volume":"235","author":"Piotrowski","year":"2021","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.hrthm.2023.06.007_bib25","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/europace\/euaa230","article-title":"Usefulness of post-procedural heart rate response to predict syncope recurrence or positive head up tilt table testing after cardioneuroablation","volume":"22","author":"Aksu","year":"2020","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2023.06.007_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/pace.12756","article-title":"Simplified cardioneuroablation in the treatment of reflex syncope, functional AV block, and sinus node dysfunction","volume":"39","author":"Aksu","year":"2016","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2023.06.007_bib27","doi-asserted-by":"crossref","unstructured":"Gopinathannair R, Olshansky B, Turagam MK, et\u00a0al. Permanent pacing versus cardioneuroablation for cardioinhibitory vasovagal syncope. J Interv Card Electrophysiol Dec 23 2022. https:\/\/doi.org\/10.1007\/s10840-022-01456-x","DOI":"10.1007\/s10840-022-01456-x"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527123023494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527123023494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:01:22Z","timestamp":1761548482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527123023494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1547527123023494"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2023.06.007","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical impact of aging on outcomes of cardioneuroablation for reflex syncope or functional bradycardia: Results from the cardionEuroabLation: patiEnt selection, imaGe integrAtioN and outComEs\u2014The ELEGANCE multicenter study","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2023.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}