{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:39:10Z","timestamp":1792539550840,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017667","name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CLRPG3N0011"],"award-info":[{"award-number":["CLRPG3N0011"]}],"id":[{"id":"10.13039\/100017667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital Linkou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.hrthm.2023.10.027","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:02:34Z","timestamp":1705276954000},"page":"321-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Incidences, risk factors, and clinical correlates of severe QT prolongation after the use of quetiapine or haloperidol"],"prefix":"10.1016","volume":"21","author":[{"given":"Chun-Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Chien-Chia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-2344","authenticated-orcid":false,"given":"Shang-Hung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2023.10.027_bib1","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1161\/CIR.0000000000000905","article-title":"Drug-induced arrhythmias: a scientific statement from the American Heart Association","volume":"142","author":"Tisdale","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2023.10.027_bib2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/postgradmedj-2020-138661","article-title":"Managing drug-induced QT prolongation in clinical practice","volume":"97","author":"Khatib","year":"2021","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.hrthm.2023.10.027_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199028","article-title":"QTc interval prolongation in critically ill patients: prevalence, risk factors and associated medications","volume":"13","author":"Fernandes","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2023.10.027_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/2045125313510194","article-title":"Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports","volume":"4","author":"Hasnain","year":"2014","journal-title":"Ther Adv Psychopharmacol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib5","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jacc.2010.01.001","article-title":"Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation","volume":"55","author":"Drew","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/1715163516641136","article-title":"Drug-induced QT interval prolongation and torsades de pointes: role of the pharmacist in risk assessment, prevention and management","volume":"149","author":"Tisdale","year":"2016","journal-title":"Can Pharm J (Ott)"},{"key":"10.1016\/j.hrthm.2023.10.027_bib7","first-page":"473","article-title":"Drug-induced QT prolongation and torsades de pointes","volume":"42","author":"Li","year":"2017","journal-title":"P T"},{"key":"10.1016\/j.hrthm.2023.10.027_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0014-2999(02)02074-5","article-title":"A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs","volume":"450","author":"Kongsamut","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib9","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1176\/appi.ajp.158.11.1774","article-title":"Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death","volume":"158","author":"Glassman","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.hrthm.2023.10.027_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1001\/archpsyc.1997.01830180067009","article-title":"Quetiapine in patients with schizophrenia: a high- and low-dose double-blind comparison with placebo","volume":"54","author":"Small","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.hrthm.2023.10.027_bib11","first-page":"401","article-title":"Low dose oral haloperidol does not prolong QTc interval in older acutely hospitalised adults: a subanalysis of a randomised double-blind placebo-controlled study","volume":"15","author":"Schrijver","year":"2018","journal-title":"J Geriatr Cardiol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0006-3223(97)00190-X","article-title":"The Seroquel Trial 13 Study Group. Multiple fixed doses of \u201cSeroquel\u201d (quetiapine) in patients with acute exacerbation of schizophrenia: a comparison with haloperidol and placebo","volume":"42","author":"Arvanitis","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.hrthm.2023.10.027_bib13","first-page":"278","article-title":"QTc prolongation and the use of antipsychotics: a case discussion","volume":"5","author":"Huffman","year":"2003","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"10.1016\/j.hrthm.2023.10.027_bib14","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1080\/15563650.2020.1746330","article-title":"Drug-specific risk of severe QT prolongation following acute drug overdose","volume":"58","author":"Campleman","year":"2020","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.hrthm.2023.10.027_bib15","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1345\/aph.19017","article-title":"Haloperidol-induced torsade de pointes","volume":"33","author":"O\u2019Brien","year":"1999","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.hrthm.2023.10.027_bib16","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1001\/archinte.1997.00440380123013","article-title":"Torsade de pointes and low-dose oral haloperidol","volume":"157","author":"Jackson","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.hrthm.2023.10.027_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12804","article-title":"QT correction using Bazett\u2019s formula remains preferable in long QT syndrome type 1 and 2","volume":"26","author":"Dahlberg","year":"2021","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib18","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1001\/jamacardio.2020.1834","article-title":"Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)","volume":"5","author":"Mercuro","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1034\/j.1600-0447.2003.02078.x","article-title":"Antipsychotics and QT prolongation","volume":"107","author":"Taylor","year":"2003","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.hrthm.2023.10.027_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/01.jcp.0000104913.75206.62","article-title":"A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition","volume":"24","author":"Harrigan","year":"2004","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.hrthm.2023.10.027_bib21","first-page":"205","article-title":"New generation antipsychotic drugs and QTc interval prolongation","volume":"5","author":"Vieweg","year":"2003","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"10.1016\/j.hrthm.2023.10.027_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.21037\/atm.2018.03.17","article-title":"Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders","volume":"6","author":"Aronow","year":"2018","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.hrthm.2023.10.027_bib23","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1176\/appi.ajp.2013.12060860","article-title":"Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study","volume":"170","author":"Girardin","year":"2013","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.hrthm.2023.10.027_bib24","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s11096-015-0242-9","article-title":"Risk management of QTc-prolongation in patients receiving haloperidol: an epidemiological study in a university hospital in Belgium","volume":"38","author":"Vandael","year":"2016","journal-title":"Int J Clin Pharm"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752712302893X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752712302893X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:00:29Z","timestamp":1761548429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154752712302893X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S154752712302893X"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2023.10.027","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidences, risk factors, and clinical correlates of severe QT prolongation after the use of quetiapine or haloperidol","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2023.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}