{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:10:45Z","timestamp":1778775045572,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0066480"],"award-info":[{"award-number":["NNF21OC0066480"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["102900011B"],"award-info":[{"award-number":["102900011B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["NNF18OC0031634"],"award-info":[{"award-number":["NNF18OC0031634"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","heartrhythmjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.hrthm.2024.01.033","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T12:02:59Z","timestamp":1706270579000},"page":"622-629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of the acetylcholine-regulated potassium current prevents transient apnea-related atrial arrhythmogenic changes in a porcine model"],"prefix":"10.1016","volume":"21","author":[{"given":"Julie","family":"Norup Hertel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Linz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Isaksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kezia","family":"Jerltorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Leonhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnela","family":"Saljic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-0824","authenticated-orcid":false,"given":"Dominik","family":"Linz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2024.01.033_bib1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cjca.2019.07.627","article-title":"Self-reported daytime sleepiness and sleep-disordered breathing in patients with atrial fibrillation: SNOozE-AF","volume":"35","author":"Kadhim","year":"2019","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/europace\/euab229","article-title":"A VIRTUAL Sleep Apnoea management pathway For the work-up of Atrial fibrillation patients in a digital Remote Infrastructure: VIRTUAL-SAFARI","volume":"24","author":"Verhaert","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.01.033_bib3","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.cjca.2021.09.026","article-title":"Prevalence and assessment of sleep-disordered breathing in patients with atrial fibrillation: a systematic review and meta-analysis","volume":"37","author":"Kadhim","year":"2021","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib4","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.hrthm.2023.04.022","article-title":"Breathless nights and heart flutters: understanding the relationship between obstructive sleep apnea and atrial fibrillation","volume":"20","author":"Mills","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.01.033_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.amjcard.2012.03.037","article-title":"Relation of the severity of obstructive sleep apnea in response to anti-arrhythmic drugs in patients with atrial fibrillation or atrial flutter","volume":"110","author":"Monahan","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/europace\/euu066","article-title":"Efficacy of catheter ablation of atrial fibrillation in patients with obstructive sleep apnoea with and without continuous positive airway pressure treatment: a meta-analysis of observational studies","volume":"16","author":"Li","year":"2014","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.01.033_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/jamacardio.2018.0095","article-title":"Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: a review","volume":"3","author":"Linz","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib8","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.hrthm.2011.03.053","article-title":"Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation","volume":"8","author":"Linz","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.01.033_bib9","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.hrthm.2021.03.017","article-title":"Arrhythmogenic mechanisms of acute obstructive respiratory events in a porcine model of drug-induced long QT","volume":"18","author":"Linz","year":"2021","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.01.033_bib10","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jacep.2019.03.005","article-title":"Variability of Sleep Apnea Severity and Risk of Atrial Fibrillation: the VARIOSA-AF Study","volume":"5","author":"Linz","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cardiores.2007.02.009","article-title":"Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation","volume":"74","author":"Voigt","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2024.01.033_bib12","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCRESAHA.111.253120","article-title":"Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling","volume":"109","author":"Makary","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.hrthm.2024.01.033_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.hroo.2021.11.013","article-title":"Pharmacological inhibition of acetylcholine-regulated potassium current (I K,ACh) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events","volume":"3","author":"Linz","year":"2022","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.hrthm.2024.01.033_bib14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00210-017-1341-z","article-title":"Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine","volume":"390","author":"B\u00e9barov\u00e1","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib15","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.jacc.2014.06.1201","article-title":"Adverse effects of cigarette and noncigarette smoke exposure on the autonomic nervous system: mechanisms and implications for cardiovascular risk","volume":"64","author":"Middlekauff","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1161\/HYPERTENSIONAHA.113.01728","article-title":"Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea","volume":"62","author":"Linz","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.hrthm.2024.01.033_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/HYPERTENSIONAHA.112.191965","article-title":"Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea","volume":"60","author":"Linz","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.hrthm.2024.01.033_bib18","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jacc.2009.09.014","article-title":"The role of ganglionated plexi in apnea-related atrial fibrillation","volume":"54","author":"Ghias","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib19","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/jce.13020","article-title":"Low-level but not high-level baroreceptor stimulation inhibits atrial fibrillation in a pig model of sleep apnea","volume":"27","author":"Linz","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib20","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1111\/bph.15100","article-title":"Effect of selective IK,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation","volume":"177","author":"Fenner","year":"2020","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.608410","article-title":"The acetylcholine-activated potassium current inhibitor XAF-1407 terminates persistent atrial fibrillation in goats","volume":"11","author":"Sobota","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jce.15769","article-title":"Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events","volume":"34","author":"Linz","year":"2023","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/107424849700200407","article-title":"Cardiac arrhythmias following intravenous nicotine: experimental study in dogs","volume":"2","author":"Mehta","year":"1997","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.hrthm.2024.01.033_bib24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/FJC.0000000000001237","article-title":"Muscarinic receptor activation reduces force and arrhythmias in human atria independent of IK,ACh","volume":"79","author":"Petersen","year":"2022","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib25","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00395-014-0427-8","article-title":"Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications","volume":"109","author":"Zhao","year":"2014","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib26","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1161\/CIR.0000000000001082","article-title":"Sleep-disordered breathing and cardiac arrhythmias in adults: mechanistic insights and clinical implications: a scientific statement from the American Heart Association","volume":"146","author":"Mehra","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.01.033_bib27","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.hrthm.2011.07.018","article-title":"Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea","volume":"8","author":"Linz","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.01.033_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/cvr\/cvm051","article-title":"Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes","volume":"77","author":"Voigt","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2024.01.033_bib29","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1161\/CIRCULATIONAHA.105.575332","article-title":"The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation","volume":"112","author":"Dobrev","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.01.033_bib30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/B978-0-12-381298-8.00032-0","article-title":"Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart","volume":"484","author":"Voigt","year":"2010","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.hrthm.2024.01.033_bib31","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.3390\/cells11162576","article-title":"Harmful impact of tobacco smoking and alcohol consumption on the atrial myocardium","volume":"11","author":"Ohlrogge","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.hrthm.2024.01.033_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223448","article-title":"The intriguing effect of ethanol and nicotine on acetylcholine-sensitive potassium current IKACh: insight from a quantitative model","volume":"14","author":"\u0160imurda","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.hrthm.2024.01.033_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110475","article-title":"The Arf6\/PIP5K pathway activates IKACh in cigarette smoke mediated atrial fibrillation","volume":"100","author":"Chidipi","year":"2022","journal-title":"Cell Signal"},{"key":"10.1016\/j.hrthm.2024.01.033_bib34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/europace\/euab109","article-title":"Obstructive sleep apnoea testing and management in atrial fibrillation patients: a joint survey by the European Heart Rhythm Association (EHRA) and the Association of Cardiovascular Nurses and Allied Professions (ACNAP)","volume":"23","author":"Desteghe","year":"2021","journal-title":"Europace"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:35:07Z","timestamp":1729139707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527124000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1547527124000870"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.01.033","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of the acetylcholine-regulated potassium current prevents transient apnea-related atrial arrhythmogenic changes in a porcine model","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.01.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Heart Rhythm Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}