{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:21:25Z","timestamp":1791883285068,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL131754"],"award-info":[{"award-number":["1R01HL131754"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","heartrhythmjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.hrthm.2024.01.058","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:33:39Z","timestamp":1707870819000},"page":"845-854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Relationship between sex, body size, and cardiac resynchronization therapy benefit: A patient-level meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-1954","authenticated-orcid":false,"given":"Daniel J.","family":"Friedman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Olivas-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Dalgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Ali-Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lurdes Y.T.","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian D.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana M.","family":"Al-Khatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2024.01.058_bib1","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1016\/j.cjco.2021.09.005","article-title":"Sex, race, and age differences of cardiovascular outcomes in cardiac resynchronization therapy RCTs: a systematic review and meta-analysis","volume":"3","author":"McKay","year":"2021","journal-title":"CJC Open"},{"key":"10.1016\/j.hrthm.2024.01.058_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cjco.2021.09.003","article-title":"Sex differences in implantation and outcomes of cardiac resynchronization therapy in real-world settings: a systematic review of cohort studies","volume":"4","author":"Dewidar","year":"2022","journal-title":"CJC Open"},{"key":"10.1016\/j.hrthm.2024.01.058_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12265-015-9663-z","article-title":"Toward sex-specific guidelines for cardiac resynchronization therapy?","volume":"9","author":"Zusterzeel","year":"2016","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.hrthm.2024.01.058_bib4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacep.2017.02.021","article-title":"Sex-specific response to cardiac resynchronization therapy: effect of left ventricular size and QRS duration in left bundle branch block","volume":"3","author":"Varma","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.118.006767","article-title":"Size matters: normalization of QRS duration to left ventricular dimension improves prediction of long-term cardiac resynchronization therapy outcome","volume":"11","author":"Zweerink","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ejhf.1133","article-title":"The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual-patient data meta-analysis","volume":"20","author":"Linde","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.hrthm.2024.01.058_bib7","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/ejhf.2524","article-title":"The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta-analysis of COMPANION and CARE-HF","volume":"24","author":"Cleland","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.hrthm.2024.01.058_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ahj.2020.02.011","article-title":"Future research prioritization in cardiac resynchronization therapy","volume":"223","author":"Fudim","year":"2020","journal-title":"Am Heart J"},{"key":"10.1016\/j.hrthm.2024.01.058_bib9","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.01.058_bib10","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1001\/jama.289.20.2685","article-title":"Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE ICD) Trial Investigators. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD trial","volume":"289","author":"Young","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2024.01.058_bib11","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1161\/01.CIR.0000146336.92331.D1","volume":"110","author":"Abraham","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.01.058_bib12","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","volume":"52","author":"Linde","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib13","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators. Cardiac-resynchronization therapy for mild-to-moderate heart failure","volume":"363","author":"Tang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.01.058_bib14","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.01.058_bib15","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.01.058_bib16","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.01.058_bib17","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.1161\/CIR.0b013e318276ce9b","volume":"127","author":"Epstein","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.01.058_bib18","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.01.058_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/europace\/euab232","article-title":"2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"24","author":"Glikson","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.01.058_bib20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.hrthm.2014.04.001","article-title":"Probability and magnitude of response to cardiac resynchronization therapy according to QRS duration and gender in nonischemic cardiomyopathy and LBBB","volume":"11","author":"Varma","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.01.058_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.121.010217","article-title":"Relationship between electrical and mechanical dyssynchrony and outcomes among patients undergoing cardiac resynchronization therapy","volume":"14","author":"Friedman","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.hroo.2020.07.004","article-title":"Sex differences in left ventricular electrical dyssynchrony and outcomes with cardiac resynchronization therapy","volume":"1","author":"Friedman","year":"2020","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.hrthm.2024.01.058_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008452","article-title":"Heart size corrected electrical dyssynchrony and its impact on sex-specific response to cardiac resynchronization therapy","volume":"14","author":"Salden","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib24","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","article-title":"Defining left bundle branch block in the era of cardiac resynchronization therapy","volume":"107","author":"Strauss","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jacc.2015.06.020","article-title":"Identification of typical left bundle branch block contraction by strain echocardiography is additive to electrocardiography in prediction of long-term outcome after cardiac resynchronization therapy","volume":"66","author":"Risum","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.01.058_bib26","first-page":"1842","article-title":"Sex and race differences in QRS duration","volume":"18","author":"Hnatkova","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.01.058_bib27","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1306687","article-title":"Cardiac-resynchronization therapy in heart failure with a narrow QRS complex","volume":"369","author":"Ruschitzka","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.01.058_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.amjcard.2022.04.027","article-title":"Comparison of frequency of ventricular tachyarrhythmia in men-versus-women in patients with implantable cardioverter-defibrillator for primary prevention","volume":"176","author":"Ojo","year":"2022","journal-title":"Am J Cardiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124001280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124001280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T18:58:32Z","timestamp":1716922712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527124001280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1547527124001280"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.01.058","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between sex, body size, and cardiac resynchronization therapy benefit: A patient-level meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.01.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of Heart Rhythm Society.","name":"copyright","label":"Copyright"}]}}