{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:03:40Z","timestamp":1788455020187,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2022-I2M-C"],"award-info":[{"award-number":["2022-I2M-C"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["T-B-049"],"award-info":[{"award-number":["T-B-049"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.hrthm.2024.09.047","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T11:53:22Z","timestamp":1726919602000},"page":"1810-1817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of serotonin and serotonergic-related metabolites in the pathogenesis of vasovagal syncope"],"prefix":"10.1016","volume":"22","author":[{"given":"Sijin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-179X","authenticated-orcid":false,"given":"Keping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2024.09.047_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-023-06680-7","article-title":"Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope","volume":"623","author":"Lovelace","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.hrthm.2024.09.047_bib2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejim.2023.03.025","article-title":"Vasovagal syncope: an overview of pathophysiological mechanisms","volume":"112","author":"Longo","year":"2023","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.hrthm.2024.09.047_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012559","article-title":"Impact of cardiovascular neurohormones on onset of vasovagal syncope induced by head-up tilt","volume":"8","author":"Torabi","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2024.09.047_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005585","article-title":"Low adrenomedullin and endothelin-1 predict cardioinhibitory response during vasovagal reflex in adults over 40 years of age","volume":"10","author":"Hamrefors","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.09.047_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejim.2022.08.037","article-title":"The role of adenosine and its degradation enzymes\u2014adenosinedeaminase and adenosinekinase in pathogenesis of vasovagal syncope","volume":"105","author":"Lazurova","year":"2022","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.hrthm.2024.09.047_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0021-5198(19)35755-5","article-title":"Serotonin (5-HT)3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives against 5-HT-induced bradycardia in anesthetized rats","volume":"65","author":"Yamano","year":"1994","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.hrthm.2024.09.047_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0735-1097(00)00719-1","article-title":"Provocation of neurocardiogenic syncope by clomipramine administration during the head-up tilt test in vasovagal syndrome","volume":"36","author":"Theodorakis","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.09.047_bib8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/eupc.1999.0088","article-title":"Role of the serotonergic system in the genesis of vasovagal syncope","volume":"2","author":"Alboni","year":"2000","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.09.047_bib9","first-page":"248","article-title":"Role of the peripheral serotoninergic system in the pathogenesis of vasovagal syncope","volume":"107","author":"Mitro","year":"2006","journal-title":"Bratisl Lek Listy"},{"key":"10.1016\/j.hrthm.2024.09.047_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/toxics4030019","article-title":"Zebrafish get connected: investigating neurotransmission targets and alterations in chemical toxicity","volume":"4","author":"Horzmann","year":"2016","journal-title":"Toxics"},{"key":"10.1016\/j.hrthm.2024.09.047_bib11","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"2018 ESC Guidelines for the diagnosis and management of syncope","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.09.047_bib12","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1161\/01.CIR.98.24.2724","article-title":"Central serotonergic responsiveness in neurocardiogenic syncope: a clomipramine test challenge","volume":"98","author":"Theodorakis","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.09.047_bib13","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0195-668X(02)00821-7","article-title":"Head-up tilt test with clomipramine challenge in vasovagal syndrome\u2014a new tilt testing protocol","volume":"24","author":"Theodorakis","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.09.047_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.118.006884","article-title":"Genetic association study in multigenerational kindreds with vasovagal syncope: evidence for involvement of sex-specific serotonin signaling","volume":"12","author":"Sheldon","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.09.047_bib15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0735-1097(98)00694-9","article-title":"Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study","volume":"33","author":"Di Girolamo","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.09.047_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/europace\/euj041","article-title":"Fluoxetine vs. propranolol in the treatment of vasovagal syncope: a prospective, randomized, placebo-controlled study","volume":"8","author":"Theodorakis","year":"2006","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.09.047_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/europace\/euw153","article-title":"Fluoxetine vs. placebo for the treatment of recurrent vasovagal syncope with anxiety sensitivity","volume":"19","author":"Flevari","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.09.047_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s10286-023-01000-5","article-title":"Serotonin reuptake inhibition for the prevention of vasovagal syncope: a systematic review and meta-analysis","volume":"33","author":"Raj","year":"2023","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.hrthm.2024.09.047_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jelechem.2009.12.020","article-title":"A disposable amperometric sensor for rapid detection of serotonin in the blood and brain of the depressed mice based on Nafion membrane-coated colloidal gold screen-printed electrode","volume":"640","author":"Liu","year":"2010","journal-title":"J Electroanal Chem"},{"key":"10.1016\/j.hrthm.2024.09.047_bib20","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.bbagen.2012.05.012","article-title":"Correlation of serotonin levels in CSF, platelets, plasma, and urine","volume":"1820","author":"Audhya","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.hrthm.2024.09.047_bib21","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1471-4159.1990.tb02319.x","article-title":"Relationship between serotoninergic measures in blood and cerebrospinal fluid simultaneously obtained in humans","volume":"54","author":"Sarrias","year":"1990","journal-title":"J Neurochem"},{"key":"10.1016\/j.hrthm.2024.09.047_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jce.13792","article-title":"Greater early epinephrine rise with head-up posture: a marker of increased syncope susceptibility in vasovagal fainters","volume":"30","author":"Kohno","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.09.047_bib23","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.hrthm.2016.03.018","article-title":"Spontaneous vs nitroglycerin-induced vasovagal reflex on head-up tilt: are there neuroendocrine differences?","volume":"13","author":"Nilsson","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.09.047_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.hrthm.2024.09.047_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10286-024-01052-1","article-title":"Serotonin and vasovagal syncope","volume":"34","author":"Alsaleh","year":"2024","journal-title":"Clin Auton Res"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124033757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124033757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:23:43Z","timestamp":1774254223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527124033757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1547527124033757"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.09.047","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of serotonin and serotonergic-related metabolites in the pathogenesis of vasovagal syncope","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}