{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:29:32Z","timestamp":1790116172813,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","heartrhythmjournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.hrthm.2024.10.061","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:54:31Z","timestamp":1731048871000},"page":"475-485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management strategies to prevent stroke in patients with atrial fibrillation and malignant left atrial appendage"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7622-8494","authenticated-orcid":false,"given":"Ryuki","family":"Chatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nishiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Mushiake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2024.10.061_bib1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0003-4975(95)00887-X","article-title":"Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation","volume":"61","author":"Blackshear","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.hrthm.2024.10.061_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.10.061_bib3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.10.061_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/europace\/euz258","article-title":"EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion\u2014an update","volume":"22","author":"Glikson","year":"2020","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.10.061_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1253\/circj.CJ-21-0162","article-title":"JCS\/JHRS 2021 guideline focused update on non-pharmacotherapy of cardiac arrhythmias","volume":"86","author":"Nogami","year":"2022","journal-title":"Circ J"},{"key":"10.1016\/j.hrthm.2024.10.061_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad204","article-title":"Diagnostic and therapeutic pathways for the malignant left atrial appendage: European Heart Rhythm Association physician survey","volume":"25","author":"Anic","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.10.061_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijcard.2022.02.030","article-title":"Residual stroke risk after left atrial appendage closure in patients with prior oral anticoagulation failure","volume":"354","author":"Praco\u0144","year":"2022","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2024.10.061_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/joa3.12838","article-title":"Left atrial appendage occlusion after thromboembolic events or left atrial appendage sludge during anticoagulation therapy: is two better than one? Real-world experience from a tertiary care hospital","volume":"39","author":"Margonato","year":"2023","journal-title":"J Arrhythm"},{"key":"10.1016\/j.hrthm.2024.10.061_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1055\/s-0040-1718729","article-title":"The East Asian paradox: an updated position statement on the challenges to the current antithrombotic strategy in patients with cardiovascular disease","volume":"121","author":"Kim","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.hrthm.2024.10.061_bib10","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.jcin.2023.05.045","article-title":"Impact of device implant depth after left atrial appendage occlusion","volume":"16","author":"Cepas-Guill\u00e9n","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hrthm.2024.10.061_bib11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/ehjci\/jeac222","article-title":"Cardiac computed tomography following Watchman FLX implantation: device-related thrombus or device healing?","volume":"24","author":"Kramer","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2024.10.061_bib12","first-page":"4","article-title":"Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies","volume":"19","author":"Tzikas","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.10.061_bib13","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1253\/circj.CJ-20-0196","article-title":"Efficacy and safety of left atrial appendage closure with WATCHMAN in Japanese nonvalvular atrial fibrillation patients\u2014final 2-year follow-up outcome data from the SALUTE trial","volume":"84","author":"Aonuma","year":"2020","journal-title":"Circ J"},{"key":"10.1016\/j.hrthm.2024.10.061_bib14","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.10.061_bib15","article-title":"Ischemic stroke severity and mortality in patients with and without atrial fibrillation","volume":"11","author":"Vinding","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2024.10.061_bib16","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/STROKEAHA.119.027275","article-title":"Atrial fibrillation-associated ischemic stroke patients with prior anticoagulation have higher risk for recurrent stroke","volume":"51","author":"Tanaka","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.hrthm.2024.10.061_bib17","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1056\/NEJMoa2101897","article-title":"Left atrial appendage occlusion during cardiac surgery to prevent stroke","volume":"384","author":"Whitlock","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2024.10.061_bib18","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.hrthm.2024.05.030","article-title":"Ischemic stroke severity and mortality after left atrial appendage closure vs nonwarfarin oral anticoagulants in patients with prior stroke","volume":"21","author":"Turagam","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.10.061_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jacep.2023.10.012","article-title":"Severity of ischemic stroke after left atrial appendage closure vs nonwarfarin oral anticoagulants","volume":"10","author":"Turagam","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.10.061_bib20","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.hrthm.2024.02.026","article-title":"Is left atrial appendage occlusion \"better\" than direct oral anticoagulants in very high risk patients with atrial fibrillation?","volume":"21","author":"Russo","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.10.061_bib21","first-page":"2914","article-title":"Left atrial appendage closure for stroke prevention in atrial fibrillation: current status and perspectives","volume":"45","author":"Landmesser","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.10.061_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.hrthm.2022.10.010","article-title":"Contemporary trends in utilization and outcomes of percutaneous left atrial appendage occlusion in the United States from 2016 to 2019","volume":"20","author":"Gupta","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.10.061_bib23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ccd.31111","article-title":"Transition from WATCHMAN generation-2.5 device to WATCHMAN FLX device for percutaneous left atrial appendage closure: incidence and predictors of device-related thrombosis and short- to mid-term outcomes","volume":"104","author":"Chatani","year":"2024","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.hrthm.2024.10.061_bib24","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.jcin.2021.07.031","article-title":"Half-dose direct oral anticoagulation versus standard antithrombotic therapy after left atrial appendage occlusion","volume":"14","author":"Della Rocca","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hrthm.2024.10.061_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2021.10.023","article-title":"4-Year outcomes after left atrial appendage closure versus nonwarfarin oral anticoagulation for atrial fibrillation","volume":"79","author":"Osmancik","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.10.061_bib26","first-page":"291","article-title":"Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis","volume":"13","author":"Najim","year":"2023","journal-title":"Am J Cardiovasc Dis"},{"key":"10.1016\/j.hrthm.2024.10.061_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jacc.2022.04.062","article-title":"Impact of peridevice leak on 5-year outcomes after left atrial appendage closure","volume":"80","author":"Dukkipati","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.10.061_bib28","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/CIRCULATIONAHA.121.057063","article-title":"Amplatzer Amulet Left Atrial Appendage Occluder versus Watchman Device for Stroke Prophylaxis (Amulet IDE): a randomized, controlled trial","volume":"144","author":"Lakkireddy","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.10.061_bib29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/eurheartj\/ehad828","article-title":"Residual leaks following percutaneous left atrial appendage occlusion and outcomes: a meta-analysis","volume":"45","author":"Samaras","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.10.061_bib30","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.jcin.2022.08.034","article-title":"Evaluation of multimodality LAA leak closure methods following incomplete occlusion: the LAA leak study","volume":"15","author":"Charate","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.hrthm.2024.10.061_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.hrthm.2024.01.046","article-title":"Minimally invasive epicardial surgical left atrial appendage exclusion for atrial fibrillation patients at high risk for stroke and for bleeding","volume":"21","author":"Rose","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.10.061_bib32","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.hrthm.2024.01.028","article-title":"Left atrial appendage closure in patients with left atrial appendage thrombus guided by intracardiac echocardiography","volume":"21","author":"Wang","year":"2024","journal-title":"Heart Rhythm"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124035264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124035264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T10:15:18Z","timestamp":1740305718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527124035264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1547527124035264"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.10.061","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management strategies to prevent stroke in patients with atrial fibrillation and malignant left atrial appendage","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.10.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}