{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:55:17Z","timestamp":1793300117842,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100019817","name":"Peter French Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007227"],"award-info":[{"award-number":["T32HL007227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30HL165535"],"award-info":[{"award-number":["L30HL165535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.hrthm.2024.12.035","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T02:44:06Z","timestamp":1735526646000},"page":"2924-2931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endurance exercise promotes episodes of myocardial injury in individuals with a pathogenic desmoplakin (DSP) variant"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-8333","authenticated-orcid":false,"given":"Alan P.","family":"Jacobsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Chiampas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Yanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Carrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Tichnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittney","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili A.","family":"Barouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2024.12.035_bib1","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1161\/CIRCULATIONAHA.119.044934","article-title":"Desmoplakin cardiomyopathy, a fibrotic and inflammatory form of cardiomyopathy distinct from typical dilated or arrhythmogenic right ventricular cardiomyopathy","volume":"141","author":"Smith","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.12.035_bib2","author":"Gasperetti"},{"key":"10.1016\/j.hrthm.2024.12.035_bib3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.amjcard.2020.12.090","article-title":"Arrhythmogenic right ventricular cardiomyopathy presenting as clinical myocarditis in women","volume":"145","author":"Scheel","year":"2021","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/europace\/euab183","article-title":"Clinical characteristics and risk stratification of desmoplakin cardiomyopathy","volume":"24","author":"Wang","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2024.12.035_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.100832","article-title":"Long-term arrhythmic follow-up and risk stratification of patients with desmoplakin-associated arrhythmogenic right ventricular cardiomyopathy","volume":"3","author":"Gasperetti","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.hrthm.2024.12.035_bib6","first-page":"2968","article-title":"A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers","volume":"45","author":"Carrick","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.12.035_bib7","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/ehf2.12658","article-title":"Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant","volume":"7","author":"Kissopoulou","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.hrthm.2024.12.035_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jchf.2022.06.013","article-title":"Acute myocarditis associated with desmosomal gene variants","volume":"10","author":"Ammirati","year":"2022","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.hrthm.2024.12.035_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015289","article-title":"Familial recurrent myocarditis triggered by exercise in patients with a truncating variant of the desmoplakin gene","volume":"9","author":"Poller","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2024.12.035_bib10","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jacc.2013.06.033","article-title":"Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers","volume":"62","author":"James","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.121.010221","article-title":"Integrating exercise into personalized ventricular arrhythmia risk prediction in arrhythmogenic right ventricular cardiomyopathy","volume":"15","author":"Bosman","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jacep.2018.01.010","article-title":"Harmful effects of exercise intensity and exercise duration in patients with arrhythmogenic cardiomyopathy","volume":"4","author":"Lie","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib13","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/eurheartj\/ehv110","article-title":"Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy","volume":"36","author":"Ruwald","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.12.035_bib14","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/ejhf.181","article-title":"Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members","volume":"16","author":"Saberniak","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.hrthm.2024.12.035_bib15","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.hrthm.2020.02.028","article-title":"Exercise and arrhythmic risk in TMEM43 p.S358L arrhythmogenic right ventricular cardiomyopathy","volume":"17","author":"Paulin","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.12.035_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012937","article-title":"Exercise is associated with impaired left ventricular systolic function in patients with lamin A\/C genotype","volume":"9","author":"Skj\u00f8lsvik","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2024.12.035_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12471-023-01800-4","article-title":"Exercise does not influence development of phenotype in PLN p.(Arg14del) cardiomyopathy","volume":"31","author":"van Lint","year":"2023","journal-title":"Neth Heart J"},{"key":"10.1016\/j.hrthm.2024.12.035_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.hrthm.2024.12.035_bib19","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/eurheartj\/ehac180","article-title":"A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy","volume":"43","author":"Cadrin-Tourigny","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.12.035_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jacc.2023.05.005","article-title":"Individualized family screening for arrhythmogenic right ventricular cardiomyopathy","volume":"82","author":"Muller","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib21","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.12.035_bib22","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1249\/MSS.0b013e31821ece12","article-title":"2011 Compendium of Physical Activities: a second update of codes and MET values","volume":"43","author":"Ainsworth","year":"2011","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.hrthm.2024.12.035_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/eurheartj\/ehaa605","article-title":"2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease","volume":"42","author":"Pelliccia","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2024.12.035_bib24","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","article-title":"2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy","volume":"16","author":"Towbin","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.12.035_bib25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.amjcard.2018.11.001","article-title":"Defining athletes and exercisers","volume":"123","author":"McKinney","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008509","article-title":"Sudden cardiac death prediction in arrhythmogenic right ventricular cardiomyopathy: a multinational collaboration","volume":"14","author":"Cadrin-Tourigny","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib27","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The physical activity guidelines for Americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2024.12.035_bib28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/CIRCULATIONAHA.121.058457","article-title":"Genetic architecture of acute myocarditis and the overlap with inherited cardiomyopathy","volume":"146","author":"Lota","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2024.12.035_bib29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jshs.2018.09.009","article-title":"The compelling link between physical activity and the body's defense system","volume":"8","author":"Nieman","year":"2019","journal-title":"J Sport Health Sci"},{"key":"10.1016\/j.hrthm.2024.12.035_bib30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.7326\/0003-4819-141-11-200412070-00005","article-title":"Sudden death in young adults: a 25-year review of autopsies in military recruits","volume":"141","author":"Eckart","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hrthm.2024.12.035_bib31","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/0002-9149(91)90251-F","article-title":"Sudden unexpected death in persons less than 40 years of age","volume":"68","author":"Drory","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib32","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jacc.2015.09.035","volume":"66","author":"Maron","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2024.12.035_bib33","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001471","article-title":"Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia\/cardiomyopathy in patients without desmosomal mutations","volume":"3","author":"Sawant","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2024.12.035_bib34","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1016\/j.hrthm.2024.05.018","article-title":"2024 HRS expert consensus statement on arrhythmias in the athlete: evaluation, treatment, and return to play","volume":"21","author":"Lampert","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2024.12.035_bib35","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.123.004133","article-title":"Characterizing decision-making surrounding exercise in ARVC: analysis of decisional conflict, decisional regret, and shared decision-making","volume":"16","author":"Sweeney","year":"2023","journal-title":"Circ Genom Precis Med"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124037081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527124037081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:03:49Z","timestamp":1778868229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527124037081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1547527124037081"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.12.035","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endurance exercise promotes episodes of myocardial injury in individuals with a pathogenic desmoplakin (DSP) variant","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2024.12.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Heart Rhythm Society.","name":"copyright","label":"Copyright"}]}}