{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:47:55Z","timestamp":1791841675660,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-EXES-0013"],"award-info":[{"award-number":["ANR-21-EXES-0013"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022108","name":"Universit\u00e9 de Poitiers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["FRM DPC20171138946"],"award-info":[{"award-number":["FRM DPC20171138946"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["FDT202106012947"],"award-info":[{"award-number":["FDT202106012947"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.hrthm.2025.04.007","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T03:06:05Z","timestamp":1744340765000},"page":"741-750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Excitability properties of cardiac calbindin neurons: Identifying a unique neuronal population"],"prefix":"10.1016","volume":"23","author":[{"given":"Gu\u00e9na\u00eblle","family":"Lizot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Bescond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"De Koninck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Chahine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Faivre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Chatelier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 1","key":"10.1016\/j.hrthm.2025.04.007_bib1","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.3949\/ccjm.74.Suppl_1.S48","article-title":"The little brain on the heart","volume":"74","author":"Armour","year":"2007","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.hrthm.2025.04.007_bib2","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1113\/JP286278","article-title":"Electrophysiology and 3D-imaging reveal properties of human intracardiac neurons and increased excitability with atrial fibrillation","volume":"603","author":"Ashton","year":"2025","journal-title":"J Physiol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib3","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1161\/CIRCULATIONAHA.109.919829","article-title":"Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs","volume":"121","author":"Choi","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2025.04.007_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14155","article-title":"Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias","volume":"8","author":"Jungen","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.hrthm.2025.04.007_bib5","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.hrthm.2022.04.012","article-title":"Molecular and functional characterization of the mouse intrinsic cardiac nervous system","volume":"19","author":"Lizot","year":"2022","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.04.007_bib6","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71720","article-title":"Juxtacellular opto-tagging of hippocampal CA1 neurons in freely moving mice","volume":"11","author":"Ding","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.hrthm.2025.04.007_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00318629","article-title":"Calbindin neurons of the guinea-pig small intestine: quantitative analysis of their numbers and projections","volume":"260","author":"Furness","year":"1990","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.hrthm.2025.04.007_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.neuroscience.2019.02.017","article-title":"Electrophysiological properties of rat subfornical organ neurons expressing calbindin D28K","volume":"404","author":"Huang","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.hrthm.2025.04.007_bib9","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/cne.24594","article-title":"Distribution, projections, and association with calbindin baskets of motor neurons, interneurons, and sensory neurons in guinea-pig distal colon","volume":"527","author":"Smolilo","year":"2019","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib10","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/s12276-021-00645-4","article-title":"Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation","volume":"53","author":"Kim","year":"2021","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.hrthm.2025.04.007_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ceca.2006.01.010","article-title":"Calbindin-D28k decreases L-type calcium channel activity and modulates intracellular calcium homeostasis in response to K+ depolarization in a rat beta cell line RINr1046-38","volume":"39","author":"Lee","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.hrthm.2025.04.007_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000210","article-title":"Hypertrophy of neurons within cardiac ganglia in human, canine, and rat heart failure: the potential role of nerve growth factor","volume":"2","author":"Singh","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2025.04.007_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnins.2017.00252","article-title":"Correlation of ventricular arrhythmogenesis with neuronal remodeling of cardiac postganglionic parasympathetic neurons in the late stage of heart failure after myocardial infarction","volume":"11","author":"Zhang","year":"2017","journal-title":"Front Neurosci"},{"key":"10.1016\/j.hrthm.2025.04.007_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2017.03.008","article-title":"Tridimensional visualization and analysis of early human development","volume":"169","author":"Belle","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.hrthm.2025.04.007_bib15","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.cell.2016.05.007","article-title":"Mapping of brain activity by automated volume analysis of immediate early genes","volume":"165","author":"Renier","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.hrthm.2025.04.007_bib16","doi-asserted-by":"crossref","first-page":"C1119","DOI":"10.1152\/ajpcell.00315.2011","article-title":"Alterations of calcium channels and cell excitability in intracardiac ganglion neurons from type 2 diabetic rats","volume":"302","author":"Liu","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib17","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007457","article-title":"Reduced N-type Ca2+ channels in atrioventricular ganglion neurons are involved in ventricular arrhythmogenesis","volume":"7","author":"Zhang","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2025.04.007_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111043","article-title":"Vitamin D, calbindin, and calcium signaling: unraveling the Alzheimer\u2019s connection","volume":"116","author":"Acharya","year":"2024","journal-title":"Cell Signal"},{"key":"10.1016\/j.hrthm.2025.04.007_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-4547(19980101)51:1<58::AID-JNR6>3.0.CO;2-K","article-title":"1\u03b1, 25 dihydroxyvitamin D3\u2013dependent up-regulation of calcium-binding proteins in motoneuron cells","volume":"51","author":"Alexianu","year":"1998","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.hrthm.2025.04.007_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00441-003-0805-2","article-title":"Immunohistochemical analysis of intracardiac ganglia of the rat heart","volume":"314","author":"Richardson","year":"2003","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.hrthm.2025.04.007_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00441-005-0105-0","article-title":"Separate neurochemical classes of sympathetic postganglionic neurons project to the left ventricle of the rat heart","volume":"324","author":"Richardson","year":"2006","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.hrthm.2025.04.007_bib22","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10571-016-0457-x","article-title":"Development of calbindin- and calretinin-immunopositive neurons in the enteric ganglia of rats","volume":"37","author":"Masliukov","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1523\/JNEUROSCI.23-03-00927.2003","article-title":"Spontaneous calcium transients in developing cortical neurons regulate axon outgrowth","volume":"23","author":"Tang","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.hrthm.2025.04.007_bib24","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s42003-022-03438-1","article-title":"Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity\u2013neuritogenesis coupling","volume":"5","author":"Yang","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib25","article-title":"Hydrogen peroxide scavenging restores N-type calcium channels in cardiac vagal postganglionic neurons and mitigates myocardial infarction-evoked ventricular arrhythmias in type 2 diabetes mellitus","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.hrthm.2025.04.007_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0169-328X(97)00305-7","article-title":"Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells","volume":"54","author":"McMahon","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.hrthm.2025.04.007_bib27","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1016\/S0006-3495(00)76537-4","article-title":"Binding kinetics of calbindin-D28k determined by flash photolysis of caged Ca2+","volume":"79","author":"N\u00e4gerl","year":"2000","journal-title":"Biophys J"},{"key":"10.1016\/j.hrthm.2025.04.007_bib28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s004240000471","article-title":"Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons","volume":"441","author":"Franciolini","year":"2001","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.hrthm.2025.04.007_bib29","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1152\/jn.01220.2005","article-title":"Developmental changes in electrophysiological properties and synaptic transmission in rat intracardiac ganglion neurons","volume":"95","author":"Rimmer","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib30","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1046\/j.1460-9568.1998.00194.x","article-title":"Calcium influx through N- and P\/Q-type channels activate apamin-sensitive calcium-dependent potassium channels generating the late afterhyperpolarization in lamprey spinal neurons","volume":"10","author":"Wikstr\u00f6m","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.hrthm.2025.04.007_bib31","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0401-21.2021","article-title":"Afterhyperpolarization promotes the firing of mitral cells through a voltage-dependent modification of action potential threshold","volume":"9","author":"Fourcaud-Trocm\u00e9","year":"2022","journal-title":"eNeuro"},{"key":"10.1016\/j.hrthm.2025.04.007_bib32","doi-asserted-by":"crossref","first-page":"C132","DOI":"10.1152\/ajpcell.00223.2013","article-title":"Heart failure\u2013induced changes of voltage-gated Ca2+ channels and cell excitability in rat cardiac postganglionic neurons","volume":"306","author":"Tu","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.hrthm.2025.04.007_bib33","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.3390\/nu13103603","article-title":"Vitamin D and cardiovascular disease: current evidence and future perspectives","volume":"13","author":"Cosentino","year":"2021","journal-title":"Nutrients"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527125023148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527125023148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:37:44Z","timestamp":1780126664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527125023148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1547527125023148"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2025.04.007","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.31.596786","asserted-by":"object"}]},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excitability properties of cardiac calbindin neurons: Identifying a unique neuronal population","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2025.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}