{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:05:47Z","timestamp":1791255947314,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.hrthm.2025.10.028","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:18:59Z","timestamp":1760804339000},"page":"2083-2092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety and performance of a novel defibrillation lead for left bundle branch area placement: Primary results of the LEADR LBBAP clinical trial"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-100X","authenticated-orcid":false,"given":"Pugazhendhi","family":"Vijayaraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Denman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Schloss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary I.","family":"Whinnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana","family":"Kron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Jastrz\u0119bski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Zakaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter P.","family":"Abhayaratna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Philippon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad R.","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parash","family":"Pokharel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Burrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Geelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Platner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiah","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela K.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George H.","family":"Crossley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2025.10.028_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.hroo.2022.08.004","article-title":"Left bundle branch pacing\u2013optimized implantable cardioverter-defibrillator (LOT-ICD) for cardiac resynchronization therapy: a pilot study","volume":"3","author":"Ponnusamy","year":"2022","journal-title":"Hear Rhythm O2"},{"key":"10.1016\/j.hrthm.2025.10.028_bib2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s10840-022-01342-6","article-title":"Dual-chamber ICD for left bundle branch area pacing: the cardiac resynchronization and arrhythmia sensing via the left bundle (cross-left) pilot study","volume":"66","author":"Clementy","year":"2023","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jacep.2023.01.006","article-title":"Left bundle branch area defibrillator (LBBAD) A first-in-human feasibility study","volume":"9","author":"Huybrechts","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.hrthm.2023.12.009","article-title":"Left bundle branch pacing lead for sensing ventricular arrhythmias in implantable cardioverter-defibrillator: A pilot study (LBBP-ICD study)","volume":"21","author":"Ponnusamy","year":"2024","journal-title":"Hear Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib5","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacep.2024.07.011","article-title":"Standard defibrillator leads for left bundle branch area pacing first-in-man experience and short-term follow-up","volume":"10","author":"Imnadze","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib6","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1016\/j.hrthm.2024.07.020","article-title":"Feasibility, safety, and short-term follow-up of defibrillator lead at left bundle branch area pacing location: a pilot study","volume":"21","author":"Ponnusamy","year":"2024","journal-title":"Hear Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib7","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib8","article-title":"Clinical Outcomes in Patients with Left Bundle Branch Area Pacing vs. Right ventricular Pacing for atrioventricular Block","volume":"8","author":"Li","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.hrthm.2025.10.028_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.hrthm.2021.08.033","article-title":"Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing: results from the Geisinger-Rush Conduction System Pacing Registry","volume":"19","author":"Sharma","year":"2022","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jacep.2020.08.015","article-title":"Left bundle branch area pacing for cardiac resynchronization therapy: results from the international LBBAP collaborative study group","volume":"7","author":"Vijayaraman","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jacc.2023.05.006","article-title":"Comparison of Left Bundle Branch Area Pacing and Biventricular Pacing in Candidates for Resynchronization Therapy","volume":"82","author":"Vijayaraman","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib12","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1111\/jce.15976","article-title":"Clinical outcomes of conduction system pacing versus biventricular pacing for cardiac resynchronization therapy: a systematic review and meta-analysis","volume":"34","author":"Kim","year":"2023","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hrthm.2021.07.057","article-title":"Left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT): results from an international LBBAP collaborative study group","volume":"19","author":"Jastrzebski","year":"2022","journal-title":"Hear Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.124.013059","article-title":"Multicenter hemodynamic assessment of the LOT-CRT strategy: when does combining left bundle branch pacing and coronary venous pacing enhance resynchronization?: primary results of the CSPOT study","volume":"17","author":"Jastrzebski","year":"2024","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib15","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/j.hrthm.2025.04.026","article-title":"Echocardiographic response from Left Bundle Branch Area Pacing Optimized Cardiac Resynchronization Therapy (LOT-CRT) versus traditional CRT","volume":"22","author":"Upadhyay","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib16","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jacep.2021.04.005","article-title":"Left bundle branch pacing optimized cardiac resynchronization therapy A novel approach","volume":"7","author":"Vijayaraman","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131230","article-title":"Safety and efficacy of left bundle branch area pacing compared with right ventricular pacing in patients with bradyarrhythmia and conduction system disorders: systematic review and meta-analysis","volume":"390","author":"Leventopoulos","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib18","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.hrthm.2024.04.067","article-title":"Safety, efficacy, and reliability evaluation ofa novel small-diameter defibrillation lead: global LEADR pivotal trial results","volume":"21","author":"Crossley","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib19","article-title":"Sensing and detection performance of the novel, small-diameter OmniaSecure defibrillation lead: in-depth analysis from the LEADR trial","volume":"27","author":"Sanders","year":"2025","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2025.10.028_bib20","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jacc.2017.06.040","article-title":"Implant and midterm outcomes of the subcutaneous implantable cardioverter-defibrillator registry","volume":"70","author":"Boersma","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib21","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCULATIONAHA.113.003042","article-title":"Safety and efficacy of a totally subcutaneous implantable-cardioverter defibrillator","volume":"128","author":"Weiss","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2025.10.028_bib24","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.hrthm.2020.05.018","article-title":"A novel 9-partition method using fluoroscopic images for guiding left bundle branch pacing","volume":"17","author":"Jiang","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.hrthm.2024.09.005","article-title":"High predicted durability for the novel small-diameter OmniaSecure defibrillation lead","volume":"22","author":"Crossley","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.122.011761","article-title":"Electrical resynchronization and clinical outcomes during long-term follow-up in intraventricular conduction delay patients applied left bundle branch pacing-optimized cardiac resynchronization therapy","volume":"16","author":"Chen","year":"2023","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib27","doi-asserted-by":"crossref","first-page":"e746","DOI":"10.1016\/j.hrthm.2024.12.039","article-title":"Intraprocedural Transthoracic EC hocardiography to Facilitate Left Bundle Branch Pacing: EC-LBBP","volume":"22","author":"Vijayaraman","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib28","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/CIRCEP.114.002344","article-title":"Troubleshooting implanted cardioverter defibrillator sensing problems I","volume":"7","author":"Swerdlow","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib29","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.hrthm.2024.05.007","article-title":"Left bundle branch area pacing using a stylet-driven, retractable-helix lead: short-term results from a prospective multicenter IDE trial (the BIO-CONDUCT study)","volume":"21","author":"Liu","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.10.028_bib30","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/jce.16274","article-title":"Result of the left bundle branch area pacing data collection registry, an international multicenter study of conduction system pacing with a Tendril STS 2088 stylet-driven lead","volume":"35","author":"Vijayaraman","year":"2024","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.10.028_bib31","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1093\/eurheartj\/ehac445","article-title":"Left bundle branch area pacing outcomes: the multicentre European MELOS study","volume":"43","author":"Jastrz\u0119bski","year":"2022","journal-title":"Eur Heart"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527125029819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527125029819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:41:45Z","timestamp":1790325705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527125029819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1547527125029819"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2025.10.028","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and performance of a novel defibrillation lead for left bundle branch area placement: Primary results of the LEADR LBBAP clinical trial","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2025.10.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Heart Rhythm Society.","name":"copyright","label":"Copyright"}]}}