{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:43:14Z","timestamp":1783024994419,"version":"3.54.6"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.hrthm.2025.12.027","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:11:39Z","timestamp":1766189499000},"page":"e755-e762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A new left atrial appendage isolation strategy for persistent atrial fibrillation requiring repeat ablation"],"prefix":"10.1016","volume":"23","author":[{"given":"Patricia","family":"Tung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"P\u00e9rez-Pinz\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Villarreal","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Locke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zimetbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory F.","family":"Michaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Waks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"d\u2019Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2025.12.027_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.109.928903","article-title":"Left atrial appendage: an underrecognized trigger site of atrial fibrillation","volume":"122","author":"Di Biase","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2025.12.027_bib2","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.jacc.2016.07.770","article-title":"Left atrial appendage isolation in patients with longstanding persistent AF undergoing catheter ablation: BELIEF trial","volume":"68","author":"Di Biase","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib3","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/europace\/euz232","article-title":"Long-term outcomes of cryoballoon-based left atrial appendage isolation in addition to pulmonary vein isolation in persistent atrial fibrillation","volume":"21","author":"Yorgun","year":"2019","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2025.12.027_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/europace\/euaa266","article-title":"Efficacy and safety of left atrial appendage electrical isolation during catheter ablation of atrial fibrillation: an updated meta-analysis","volume":"23","author":"Romero","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2025.12.027_bib5","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/europace\/eux372","article-title":"Benefit of left atrial appendage electrical isolation for persistent and long-standing persistent atrial fibrillation: a systematic review and meta-analysis","volume":"20","author":"Romero","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2025.12.027_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008390","article-title":"Long-term outcomes of left atrial appendage electrical isolation in patients with nonparoxysmal atrial fibrillation: a propensity score-matched analysis","volume":"13","author":"Romero","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib7","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCULATIONAHA.118.037451","article-title":"Left atrial appendage isolation in patients not responding to pulmonary vein isolation: benefit and risks","volume":"139","author":"Heeger","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2025.12.027_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.115.003461","article-title":"Unexpectedly high incidence of stroke and left atrial appendage thrombus formation after electrical isolation of the left atrial appendage for the treatment of atrial tachyarrhythmias","volume":"9","author":"Rillig","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib9","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/CIRCULATIONAHA.124.069993","article-title":"Ablation strategies for repeat procedures in atrial fibrillation recurrences despite durable pulmonary vein isolation: the prospective randomized ASTRO AF multicenter trial","volume":"150","author":"Schmidt","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2025.12.027_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.125.014026","article-title":"Feasibility and safety of pulsed field ablation for coronary sinus and left atrial appendage isolation and mitral isthmus ablation: acute and chronic findings","volume":"18","author":"La Fazia","year":"2025","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib11","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.hroo.2024.08.008","article-title":"Predictors of first-pass isolation in patients with recurrent atrial fibrillation: a retrospective cohort study","volume":"5","author":"P\u00e9rez-Pinz\u00f3n","year":"2024","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.hrthm.2025.12.027_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10840-019-00657-1","article-title":"Exclusion of electrical and mechanical function of the left atrial appendage in patients with persistent atrial fibrillation: differences in efficacy and safety between endocardial ablation vs epicardial LARIAT ligation (the EXCLUDE LAA study)","volume":"57","author":"Parikh","year":"2020","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.hrthm.2016.11.009","article-title":"Durability of wide-area left atrial appendage isolation: results from extensive catheter ablation for treatment of persistent atrial fibrillation","volume":"14","author":"Reissmann","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2025.12.027_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.hroo.2024.11.018","article-title":"Electrical isolation of the left atrial appendage in East Asian patients with atrial fibrillation","volume":"6","author":"Park","year":"2025","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.hrthm.2025.12.027_bib15","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1056\/NEJMoa1408288","article-title":"Approaches to catheter ablation for persistent atrial fibrillation","volume":"372","author":"Verma","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2025.12.027_bib16","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1001\/jama.2020.16195","article-title":"Effect of catheter ablation with vein of Marshall ethanol infusion vs catheter ablation alone on persistent atrial fibrillation: the VENUS randomized clinical trial","volume":"324","author":"Valderr\u00e1bano","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2025.12.027_bib17","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1540-8167.2005.50192.x","article-title":"Left mitral isthmus ablation associated with PV Isolation: long-term results of a prospective randomized study","volume":"16","author":"Fassini","year":"2005","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib18","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.3390\/jcm12216916","article-title":"Clinical medicine impact of vein of Marshall ethanol infusion combined with anatomical ablation for the treatment of persistent atrial fibrillation: a long-term follow-up based on implantable loop recorders","volume":"12","author":"Nesti","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.hrthm.2025.12.027_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10840-024-01877-w","article-title":"Vein of Marshall ethanol infusion for recurrent atrial fibrillation in patients with durably isolated pulmonary veins","volume":"68","author":"Cunn","year":"2025","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2025.12.027_bib20","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1111\/jce.70114","article-title":"Vein of Marshall ethanol ablation as a strategy for recurrent persistent atrial fibrillation","volume":"36","author":"Hsia","year":"2025","journal-title":"J Cardiovasc Electrophysiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527125031650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527125031650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:01:29Z","timestamp":1779912089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527125031650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1547527125031650"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2025.12.027","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new left atrial appendage isolation strategy for persistent atrial fibrillation requiring repeat ablation","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2025.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}