{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:24:07Z","timestamp":1787736247273,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.hrthm.2026.03.001","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:53:14Z","timestamp":1772700794000},"page":"e2162-e2166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk stratification in short QT syndrome: Findings from a pooled analysis"],"prefix":"10.1016","volume":"23","author":[{"given":"Moshe","family":"Giladi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Viskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"van der Werf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soesja","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.","family":"Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Elbassel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Martijn","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Viskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-1162","authenticated-orcid":false,"given":"Ehud","family":"Chorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2026.03.001_bib1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jacc.2013.09.078","article-title":"Novel insight into the natural history of short QT syndrome","volume":"63","author":"Mazzanti","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jacc.2011.03.038","article-title":"Long-term follow-up of patients with short QT syndrome","volume":"58","author":"Giustetto","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib3","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.CIR.0000085071.28695.C4","article-title":"Short QT Syndrome: a familial cause of sudden death","volume":"108","author":"Gaita","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.001_bib4","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/01.CIR.84.3.1136","article-title":"The long QT syndrome. Prospective longitudinal study of 328 families","volume":"84","author":"Moss","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.001_bib5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMoa022147","article-title":"Risk stratification in the long-QT syndrome","volume":"348","author":"Priori","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2026.03.001_bib6","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jacc.2010.09.048","article-title":"The short QT syndrome: proposed diagnostic criteria","volume":"57","author":"Gollob","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib7","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.jacep.2025.03.027","article-title":"A gain-of -function SLC4A3 mutation causes short-QT syndrome: from molecular analysis to novel diagnostic testing","volume":"11","author":"Giladi","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib8","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1161\/01.CIR.0000130409.72142.FE","article-title":"Mutation in the KCNQ1 gene leading to the short QT-interval syndrome","volume":"109","author":"Bellocq","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.001_bib9","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.hrthm.2026.03.001_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000047299","article-title":"Idiopathic short QT interval: a new clinical syndrome?","volume":"94","author":"Gussak","year":"2000","journal-title":"Cardiology"},{"key":"10.1016\/j.hrthm.2026.03.001_bib11","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2026.03.001_bib12","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1080\/08035250600763042","article-title":"Familial idiopathic atrial fibrillation with fetal bradyarrhythmia","volume":"95","author":"Aburawi","year":"2006","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.hrthm.2026.03.001_bib13","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1093\/hmg\/ddu201","article-title":"Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype","volume":"23","author":"Ambrosini","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.hrthm.2026.03.001_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/CIRCULATIONAHA.106.668392","article-title":"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death","volume":"115","author":"Antzelevitch","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.001_bib15","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1111\/jce.70126","article-title":"A novel variant in SLC4A3 gene mutation associated with familial short QT syndrome and sudden death","volume":"36","author":"Crea","year":"2025","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib16","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/CIRCEP.115.003256","article-title":"Short QT interval prevalence and clinical outcomes in a pediatric population","volume":"8","author":"Guerrier","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib17","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/pace.70018","article-title":"Cardioneuroablation for the treatment of vagal mediated ventricular fibrillation in short QT syndrome, case report","volume":"48","author":"Hamayel","year":"2025","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijcard.2015.04.090","article-title":"Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome","volume":"190","author":"Harrell","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cardiores.2005.06.023","article-title":"De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero","volume":"68","author":"Hong","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2026.03.001_bib20","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1253\/circj.CJ-24-0927","article-title":"Congenital short QT syndrome - review focused on KCNQ1 p.Val141Met variant","volume":"90","author":"Horie","year":"2026","journal-title":"Circ J"},{"key":"10.1016\/j.hrthm.2026.03.001_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0167-5273(91)90014-G","article-title":"Lone atrial fibrillation with complete heart block in a child","volume":"30","author":"Kumar","year":"1991","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijcard.2013.11.078","article-title":"Type 2 short QT syndrome and vestibular dysfunction: mirror of the Jervell and Lange-Nielsen syndrome?","volume":"171","author":"Maltret","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib23","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/europace\/euab097","article-title":"Novel electrocardiographic criteria for short QT syndrome in children and adolescents","volume":"23","author":"Suzuki","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.03.001_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000360758","article-title":"Short QT syndrome manifesting with neonatal atrial fibrillation and bradycardia","volume":"128","author":"Villafane","year":"2014","journal-title":"Cardiology"},{"key":"10.1016\/j.hrthm.2026.03.001_bib25","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41467-017-01630-0","article-title":"Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome","volume":"8","author":"Thorsen","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.hrthm.2026.03.001_bib26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.hrcr.2025.10.006","article-title":"When targeted gene testing falls short: case report of a novel SLC4A3 F347S genetic variant associated with short QT syndrome","volume":"12","author":"Boyd","year":"2025","journal-title":"HeartRhythm Case Rep"},{"key":"10.1016\/j.hrthm.2026.03.001_bib27","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/eurheartj\/ehab687","article-title":"Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death","volume":"43","author":"Walsh","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2026.03.001_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1540-8167.2001.00411.x","article-title":"Problems of heart rate correction in assessment of drug-induced QT interval prolongation","volume":"12","author":"Malik","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.001_bib29","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/CIRCULATIONAHA.118.033943","article-title":"Determination and interpretation of the QT interval","volume":"138","author":"Vink","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.001_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.hrthm.2016.09.013","article-title":"Female gender as independent risk factor of torsades de pointes during acquired atrioventricular block","volume":"14","author":"Chorin","year":"2017","journal-title":"Heart Rhythm"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527126002146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527126002146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:05:50Z","timestamp":1787735150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527126002146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1547527126002146"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.03.001","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk stratification in short QT syndrome: Findings from a pooled analysis","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}