{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:26:19Z","timestamp":1793942779699,"version":"4.8.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.hrthm.2026.03.1961","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:42:36Z","timestamp":1775634156000},"page":"e1672-e1682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Atrial fibrillation in hypertrophic cardiomyopathy: A unique clinical entity requiring dedicated study"],"prefix":"10.1016","volume":"23","author":[{"given":"Ethan J.","family":"Rowin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos C.","family":"Siontis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Moussavi-Harami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve R.","family":"Ommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Nazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.A. Mark","family":"Estes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Massera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Ahamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2026.03.1961_bib1","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1161\/CIRCULATIONAHA.117.029267","article-title":"Clinical profile and consequences of atrial fibrillation in hypertrophic cardiomyopathy","volume":"136","author":"Rowin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib2","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1161\/CIRCULATIONAHA.123.065037","article-title":"Evolving contemporary management of atrial fibrillation in hypertrophic cardiomyopathy","volume":"148","author":"Rowin","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib3","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.jacc.2020.08.045","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"76","author":"Ommen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib4","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.038755","article-title":"Health care resource use and economic burden in patients with symptomatic obstructive hypertrophic cardiomyopathy and atrial fibrillation","volume":"14","author":"Stendahl","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib7","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/hc4601.097997","article-title":"Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy","volume":"104","author":"Olivotto","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib8","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jacep.2021.04.004","article-title":"Predictors of major atrial fibrillation endpoints in the National Heart, Lung, and Blood Institute HCMR","volume":"7","author":"Kramer","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/heartjnl-2016-309672","article-title":"Predictors of atrial fibrillation in hypertrophic cardiomyopathy","volume":"103","author":"Guttmann","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/jce.12982","article-title":"High incidence of de novo and subclinical atrial fibrillation in patients with hypertrophic cardiomyopathy and cardiac rhythm management device","volume":"27","author":"Wilke","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/jce.14792","article-title":"EvaLuation Using Cardiac Insertable Devices and TelephonE in hypertrophic cardiomyopathy (ELUCIDATE HCM): a prospective observational study on incidence of arrhythmias","volume":"32","author":"Magnusson","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib12","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.amjcard.2017.02.040","article-title":"Occurrence and natural history of clinically silent episodes of atrial fibrillation in hypertrophic cardiomyopathy","volume":"119","author":"Rowin","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijcard.2023.04.005","article-title":"How common is hypertrophic cardiomyopathy\u2026 really?: disease prevalence revisited 27 years after CARDIA","volume":"382","author":"Massera","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib14","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1002\/ehf2.12854","article-title":"Atrial fibrillation, anticoagulation management and risk of stroke in the cardiomyopathy\/myocarditis registry of the EURObservational Research Programme of the European Society of Cardiology","volume":"7","author":"Mizia-Stec","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib15","article-title":"Atrial fibrillation recurrence and outcomes in patients with hypertrophic cardiomyopathy: Insights from a nationwide real-world cohort","author":"Aglan","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib16","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/CIRCEP.113.000339","article-title":"Catheter ablation of atrial fibrillation in hypertrophic cardiomyopathy long-term outcomes and mechanisms of arrhythmia recurrence","volume":"6","author":"Santangeli","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.amjcard.2020.09.006","article-title":"Predictors and mechanisms of atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"136","author":"Raphael","year":"2020","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib18","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/cvr\/cvaa124","article-title":"Abnormalities in sodium current and calcium homoeostasis as drivers of arrhythmogenesis in hypertrophic cardiomyopathy","volume":"116","author":"Coppini","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/japplphysiol.00339.2025","article-title":"Heterozygous MYH7 R403Q mutation impairs left atrial mitochondrial function in a Yucatan mini-pig model of genetic nonobstructive hypertrophic cardiomyopathy","volume":"139","author":"Krause","year":"2025","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib20","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.3390\/ijms22136941","article-title":"Electrophysiological and structural remodeling of the atria in a mouse model of troponin-I mutation linked hypertrophic cardiomyopathy: implications for atrial fibrillation","volume":"22","author":"Lim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.864547","article-title":"Genotype-driven pathogenesis of atrial fibrillation in hypertrophic cardiomyopathy: the case of different TNNT2 mutations","volume":"13","author":"Pioner","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib22","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.3390\/cells10102789","article-title":"Ion channel impairment and myofilament Ca2+ sensitization: two parallel mechanisms underlying arrhythmogenesis in hypertrophic cardiomyopathy","volume":"10","author":"Santini","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib23","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/echo.15434","article-title":"Prognostic significance of left atrial strain in sarcomere gene variant carriers without hypertrophic cardiomyopathy","volume":"39","author":"Huurman","year":"2022","journal-title":"Echocardiography"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1532-429X-12-13","article-title":"How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance","volume":"12","author":"Germans","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12968-017-0420-0","article-title":"Left Atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy","volume":"19","author":"Farhad","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib26","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1001\/jamacardio.2021.3370","article-title":"Early-onset atrial fibrillation and the prevalence of rare variants in cardiomyopathy and arrhythmia genes","volume":"6","author":"Yoneda","year":"2021","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005191","article-title":"Incident atrial fibrillation is associated with MYH7 sarcomeric gene variation in hypertrophic cardiomyopathy","volume":"11","author":"Lee","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.009796","article-title":"Development and validation of a clinical predictive model for identifying hypertrophic cardiomyopathy patients at risk for atrial fibrillation: the HCM-AF score","volume":"14","author":"Carrick","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pcad.2025.07.004","article-title":"Left atrial size trajectories and outcome over a 35-year follow-up in patients with hypertrophic cardiomyopathy","volume":"92","author":"Di Napoli","year":"2025","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101210","article-title":"Atrial fibrillation in hypertrophic cardiomyopathy","volume":"3","author":"Weissler-Snir","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10840-023-01533-9","article-title":"Conduction velocity is reduced in the posterior wall of hypertrophic cardiomyopathy patients with normal bipolar voltage undergoing ablation for paroxysmal atrial fibrillation","volume":"67","author":"Zahid","year":"2024","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jelectrocard.2021.06.001","article-title":"Atrial substrate characterization in patients with atrial fibrillation and hypertrophic cardiomyopathy: evidence for an extensive fibrotic disease","volume":"69","author":"Efremidis","year":"2021","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib33","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.jacep.2024.03.026","article-title":"Atrial fibrillation substrate and catheter ablation outcomes in MYBPC3- and MYH7-mediated hypertrophic cardiomyopathy","volume":"10","author":"Haq","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib34","doi-asserted-by":"crossref","first-page":"e1241","DOI":"10.1016\/j.hrthm.2025.08.008","article-title":"Left atrial late gadolinium enhancement and atrial fibrillation in hypertrophic cardiomyopathy","volume":"22","author":"Garbin","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib35","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jacep.2018.10.016","article-title":"Hypertrophic cardiomyopathy patients with paroxysmal atrial fibrillation have a high burden of left atrial fibrosis by cardiac magnetic resonance imaging","volume":"5","author":"Sivalokanathan","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib36","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s10840-025-02027-6","article-title":"Impact of catheter ablation on atrial fibrillation outcomes in various cardiomyopathies: findings from LGE-MRI quantified atrial fibrosis analysis","volume":"68","author":"Kassar","year":"2025","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib37","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.hrthm.2024.01.022","article-title":"Biatrial arrhythmogenic substrate in patients with hypertrophic obstructive cardiomyopathy","volume":"21","author":"Ramdat Misier","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.hrcr.2021.03.017","article-title":"Characterization of atrial histology in a patient with hypertrophic cardiomyopathy: possible evidence of a primary atrial myopathy","volume":"7","author":"Keane","year":"2021","journal-title":"HeartRhythm Case Rep"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004052","article-title":"Left atrial size and function in hypertrophic cardiomyopathy patients and risk of new-onset atrial fibrillation","volume":"10","author":"Debonnaire","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmg.2025.07.008","article-title":"Left atrial reservoir strain predicts atrial fibrillation in hypertrophic cardiomyopathy: insights from the NHLBI HCM registry","volume":"19","author":"Beyhoff","year":"2026","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/jama.2024.22451","article-title":"Atrial fibrillation: a review","volume":"333","author":"Ko","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJMcp2023658","article-title":"Atrial fibrillation","volume":"384","author":"Michaud","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/jce.15304","article-title":"Impact of comorbidities on atrial fibrillation and sudden cardiac death in hypertrophic cardiomyopathy","volume":"33","author":"Sridharan","year":"2022","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jamacardio.2019.4268","article-title":"Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy","volume":"5","author":"Fumagalli","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib45","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015013","article-title":"Implication of apnea-hypopnea index, a measure of obstructive sleep apnea severity, for atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"9","author":"Xu","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib46","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/jamacardio.2025.2877","article-title":"Prevalence and clinical implications of sleep apnea in hypertrophic cardiomyopathy","volume":"10","author":"Karim","year":"2025","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib47","doi-asserted-by":"crossref","first-page":"e841","DOI":"10.1016\/j.hrthm.2025.05.046","article-title":"External validation of atrial fibrillation risk prediction tools in a racially diverse cohort of patients with hypertrophic cardiomyopathy","volume":"22","author":"Pronovost","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib48","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/heartjnl-2013-304276","article-title":"Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review","volume":"100","author":"Guttmann","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.hrthm.2020.09.018","article-title":"Anticoagulation for stroke prevention in patients with hypertrophic cardiomyopathy and atrial fibrillation: a review","volume":"18","author":"Nasser","year":"2021","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib50","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.hrthm.2018.11.029","article-title":"Effect of hypertrophic cardiomyopathy on the prediction of thromboembolism in patients with nonvalvular atrial fibrillation","volume":"16","author":"Tsuda","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib51","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2023.05.021","article-title":"Risk of left atrial thrombus in patients with hypertrophic cardiomyopathy and atrial fibrillation","volume":"82","author":"Burczak","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib52","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.hrthm.2025.07.010","article-title":"Utility of transesophageal echocardiography prior to cardioversion in patients with atrial fibrillation and hypertrophic cardiomyopathy","volume":"23","author":"Ibrahim","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib53","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.042010","article-title":"Left atrial appendage thrombus in patients with hypertrophic cardiomyopathy and atrial fibrillation: prevalence and risk factors","volume":"15","author":"Dinshaw","year":"2026","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib54","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.hrthm.2024.05.038","article-title":"Percutaneous left atrial appendage closure for stroke prevention in hypertrophic cardiomyopathy patients with atrial fibrillation","volume":"21","author":"Aglan","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib55","article-title":"Prevalence, risk factors, and outcomes of QT prolongation in primary and RASopathy-associated hypertrophic cardiomyopathy","author":"\u00d6sterberg","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib56","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/pace.13310","article-title":"Dofetilide for suppression of atrial fibrillation in hypertrophic cardiomyopathy: a case series and literature review","volume":"41","author":"Moore","year":"2018","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib57","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.amjcard.2019.02.051","article-title":"Safety, side effects and relative efficacy of medications for rhythm control of atrial fibrillation in hypertrophic cardiomyopathy","volume":"123","author":"Miller","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib58","first-page":"335","article-title":"Effect of sotalol on arrhythmias and exercise tolerance in patients with hypertrophic cardiomyopathy","volume":"82","author":"Tendera","year":"1993","journal-title":"Cardiology"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib59","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jacc.2005.01.012","article-title":"Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy","volume":"45","author":"Sherrid","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s43856-023-00315-8","article-title":"Efficacy and safety of dofetilide and sotalol in patients with hypertrophic cardiomyopathy","volume":"3","author":"Chen","year":"2023","journal-title":"Commun Med (Lond)"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib61","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037639","article-title":"Disopyramide revisited for treatment of symptomatic obstructive hypertrophic cardiomyopathy: efficacy and safety in patients treated for at least 5 years","volume":"14","author":"Massera","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib62","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/europace\/euab022","article-title":"Catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a European observational multicentre study","volume":"23","author":"Creta","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib63","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.hrthm.2005.11.013","article-title":"Efficacy of catheter ablation of atrial fibrillation in patients with hypertrophic obstructive cardiomyopathy","volume":"3","author":"Kilicaslan","year":"2006","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib64","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1136\/heartjnl-2016-309406","article-title":"Catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: a systematic review and meta-analysis","volume":"102","author":"Providencia","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib65","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/jce.14880","article-title":"Transcatheter ablation for atrial fibrillation in patients with hypertrophic cardiomyopathy: long-term results and clinical outcomes","volume":"32","author":"Castagno","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib66","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1540-8167.2008.01192.x","article-title":"Substrate and procedural predictors of outcomes after catheter ablation for atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"19","author":"Bunch","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib67","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017451","article-title":"Ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: treatment strategy, characteristics of consecutive atrial tachycardia and long-term outcome","volume":"10","author":"Dinshaw","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad256","article-title":"Catheter ablation of atrial fibrillation in patients with and without hypertrophic cardiomyopathy: systematic review and meta-analysis","volume":"25","author":"Ezzeddine","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib69","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.hroo.2023.01.002","article-title":"Catheter ablation of atrial fibrillation in hypertrophic cardiomyopathy: a proportional meta-analysis and systematic review of single-arm studies","volume":"4","author":"Latif","year":"2023","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib70","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.hrthm.2015.03.042","article-title":"Outcomes of nonpharmacologic treatment of atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"12","author":"Bassiouny","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1056\/NEJMoa2212540","article-title":"Progression of atrial fibrillation after cryoablation or drug therapy","volume":"388","author":"Andrade","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib72","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1016\/j.hrthm.2017.05.012","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"14","author":"Calkins","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib73","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jacep.2025.01.009","article-title":"Pulsed-field vs thermal catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"11","author":"Gribissa","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib74","first-page":"2690","article-title":"Impact of catheter ablation on atrial fibrillation burden and symptoms in patients with hypertrophic cardiomyopathy","volume":"10","author":"Ahluwalia","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib75","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/jce.16192","article-title":"Assessing the impact of atrial fibrillation on symptoms and quality of life in hypertrophic cardiomyopathy","volume":"35","author":"Rowin","year":"2024","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib76","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1056\/NEJMoa2504654","article-title":"Aficamten or metoprolol monotherapy for obstructive hypertrophic cardiomyopathy","volume":"393","author":"Garcia-Pavia","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib77","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jacc.2025.11.028","article-title":"Beta-blocker (bisoprolol) vs calcium-channel blocker (verapamil) in nonobstructive hypertrophic cardiomyopathy: a randomized triple-crossover physiologic trial","volume":"87","author":"Bjerregaard","year":"2026","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib78","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.hrthm.2023.08.028","article-title":"Atrioventricular nodal ablation is an effective management strategy for atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"20","author":"Butcher","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euaf208","article-title":"Atrioventricular node ablation for refractory atrial fibrillation in patients with hypertrophic cardiomyopathy: a case-control study","volume":"27","author":"Debertin","year":"2025","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib80","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2019.05.053","article-title":"Conduction abnormalities and long-term mortality following septal myectomy in patients with obstructive hypertrophic cardiomyopathy","volume":"74","author":"Cui","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib81","article-title":"QRS duration, left bundle branch block morphology, and outcomes among patients undergoing septal myectomy","author":"Song","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib82","doi-asserted-by":"crossref","first-page":"36","DOI":"10.21037\/cdt.2016.11.23","article-title":"Outcomes in hypertrophic cardiomyopathy patients with and without atrial fibrillation: a survival meta-analysis","volume":"7","author":"Masri","year":"2017","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib83","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021970","article-title":"Atrial fibrillation in patients with cardiomyopathy: prevalence and clinical outcomes from real-world data","volume":"10","author":"Buckley","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib84","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000354953","article-title":"Clinical profile and prognostic significance of atrial fibrillation in hypertrophic cardiomyopathy","volume":"126","author":"Tian","year":"2013","journal-title":"Cardiology"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib85","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijcard.2020.07.036","article-title":"Prevalence, causes and predictors of cardiovascular hospitalization in patients with hypertrophic cardiomyopathy","volume":"318","author":"Ciabatti","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib86","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.amjcard.2022.05.032","article-title":"Ventricular septal myectomy decreases long-term risk for atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"179","author":"Rowin","year":"2022","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib87","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1111\/jocs.14946","article-title":"Surgical ablation of atrial fibrillation in hypertrophic obstructive cardiomyopathy: outcomes of a tailored surgical approach","volume":"35","author":"Hodges","year":"2020","journal-title":"J Card Surg"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib88","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jtcvs.2020.08.066","article-title":"Does ablation of atrial fibrillation at the time of septal myectomy improve survival of patients with obstructive hypertrophic cardiomyopathy?","volume":"161","author":"Cui","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib89","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib90","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/CIRCULATIONAHA.122.062534","article-title":"Dose-blinded myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy: outcomes through 32-weeks","volume":"147","author":"Desai","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib91","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.hrthm.2024.04.055","article-title":"Incidence of newly recognized atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy treated with Mavacamten","volume":"21","author":"Castrichini","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardfail.2026.02.035","article-title":"Incidence and outcomes of atrial fibrillation and systolic dysfunction in patients receiving mavacamten for obstructive hypertrophic cardiomyopathy: a multicenter study","author":"Nguyen","year":"2026","journal-title":"J Card Fail"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib93","article-title":"Safety and efficacy of mavacamten and aficamten in patients with hypertrophic cardiomyopathy","volume":"14","author":"Davis","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib94","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jacep.2024.10.014","article-title":"Atrial fibrillation in patients receiving mavacamten for obstructive hypertrophic cardiomyopathy: real-world incidence, management, and outcomes","volume":"11","author":"Boyle","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib95","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1161\/CIRCULATIONAHA.124.072445","article-title":"Mavacamten in patients with hypertrophic cardiomyopathy referred for septal reduction: week 128 results from VALOR-HCM","volume":"151","author":"Desai","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib96","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1093\/eurheartj\/ehae579","article-title":"Long-term effect of mavacamten in obstructive hypertrophic cardiomyopathy","volume":"45","author":"Garcia-Pavia","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib97","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.hrthm.2025.08.031","article-title":"Low incidence of atrial fibrillation in patients with obstructive hypertrophic cardiomyopathy treated with aficamten: an analysis from the REDWOOD-HCM, SEQUOIA-HCM, and FOREST-HCM trials","volume":"23","author":"Rowin","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.03.1961_bib98","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.hrthm.2024.11.041","article-title":"Managing drug\u2013drug interactions with mavacamten: a focus on combined use of antiarrhythmic drugs and anticoagulants","volume":"22","author":"Ricci","year":"2025","journal-title":"Heart Rhythm"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527126022459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527126022459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:41:44Z","timestamp":1793940104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527126022459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":98,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1547527126022459"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.03.1961","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atrial fibrillation in hypertrophic cardiomyopathy: A unique clinical entity requiring dedicated study","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.03.1961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Heart Rhythm Society.","name":"copyright","label":"Copyright"}]}}