{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:39:51Z","timestamp":1793176791931,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.hrthm.2026.05.021","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:28:40Z","timestamp":1778891320000},"page":"e2846-e2854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sudden cardiac death and major arrhythmic events in patients with Fabry disease: Risk stratification in the French Heart Fabry cohort multicenter study"],"prefix":"10.1016","volume":"23","author":[{"given":"Yassine","family":"Temmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Proukhnitzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lamblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"R\u00e9ant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Labombarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Cappel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Palmyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mansencal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wladimir","family":"Mauhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Pruny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hichem","family":"Sakhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Gandjbakhch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2026.05.021_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pcad.2025.08.003","article-title":"Fabry disease cardiomyopathy: a state-of-the-art review","volume":"92","author":"Pande","year":"2025","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.hrthm.2026.05.021_bib2","series-title":"Fabry Disease: Perspectives from 5 Years of FOS","article-title":"Biochemical and genetic diagnosis of Fabry disease","author":"Winchester","year":"2006"},{"key":"10.1016\/j.hrthm.2026.05.021_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/mgg3.389","article-title":"Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: a multicenter Fabry registry study","volume":"6","author":"Germain","year":"2018","journal-title":"Mol Genet Genom Med"},{"issue":"suppl 1","key":"10.1016\/j.hrthm.2026.05.021_bib4","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1590\/1806-9282.66.s1.10","article-title":"Fabry disease: genetics, pathology, and treatment","volume":"66","author":"Bernardes","year":"2020","journal-title":"Rev Assoc Med Bras"},{"key":"10.1016\/j.hrthm.2026.05.021_bib5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jacc.2010.11.018","article-title":"Cardiovascular events in patients with Fabry disease natural history data from the Fabry registry","volume":"57","author":"Patel","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.05.021_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1750-1172-5-30","article-title":"Fabry disease","volume":"5","author":"Germain","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.hrthm.2026.05.021_bib7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/clc.22047","article-title":"Arrhythmias in Fabry cardiomyopathy","volume":"35","author":"Acharya","year":"2012","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.hrthm.2026.05.021_bib8","doi-asserted-by":"crossref","first-page":"f153","DOI":"10.1093\/europace\/eux261","article-title":"Ventricular arrhythmia and sudden cardiac death in Fabry disease: a systematic review of risk factors in clinical practice","volume":"20","author":"Baig","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.05.021_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.acvd.2019.01.002","article-title":"Fabry disease in cardiology practice: literature review and expert point of view","volume":"112","author":"Hag\u00e8ge","year":"2019","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.hrthm.2026.05.021_bib10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ymgme.2018.02.014","article-title":"Fabry disease revisited: management and treatment recommendations for adult patients","volume":"123","author":"Ortiz","year":"2018","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.hrthm.2026.05.021_bib11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/diagnostics15020139","article-title":"Anderson-Fabry disease: an overview of current diagnosis, arrhythmic risk stratification, and therapeutic strategies","volume":"15","author":"Tognola","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.hrthm.2026.05.021_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.hrthm.2026.05.021_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1540-8159.2005.00241.x","article-title":"Ventricular tachycardias and dilated cardiomyopathy caused by Fabry disease","volume":"28","author":"Igawa","year":"2005","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.05.021_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1148\/radiol.2019191385","article-title":"Left ventricular hypertrophy and late gadolinium enhancement at cardiac MRI are associated with adverse cardiac events in Fabry disease","volume":"294","author":"Hanneman","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.hrthm.2026.05.021_bib15","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jacc.2022.06.022","article-title":"Validated model for prediction of adverse cardiac outcome in patients with Fabry disease","volume":"80","author":"Orsborne","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrthm.2026.05.021_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/08035320600618809","article-title":"Disease manifestations and X inactivation in heterozygous females with Fabry disease","volume":"95","author":"Maier","year":"2006","journal-title":"Acta Paediatr Suppl"},{"key":"10.1016\/j.hrthm.2026.05.021_bib17","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1136\/heartjnl-2020-317922","article-title":"Influence of sex and phenotype on cardiac outcomes in patients with Fabry disease","volume":"107","author":"El Sayed","year":"2021","journal-title":"Heart"},{"key":"10.1016\/j.hrthm.2026.05.021_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM200107053450102","article-title":"Safety and efficacy of recombinant human alpha-galactosidase A replacement therapy in Fabry\u2019s disease","volume":"345","author":"Eng","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2026.05.021_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1148\/radiol.2019192141","article-title":"Grading cardiac risk in Fabry disease: is MRI the answer?","volume":"294","author":"Zimmerman","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.hrthm.2026.05.021_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2025.134078","article-title":"Multimodality imaging assessment of cardiac involvement in classic and late-onset Anderson-Fabry disease","volume":"446","author":"Fan","year":"2026","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrthm.2026.05.021_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijcard.2023.04.016","article-title":"Clinical and CMR characteristics associated with cardiac events in patients with Fabry disease","volume":"382","author":"Hiestand","year":"2023","journal-title":"Int J Cardiol"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752712602388X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154752712602388X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:28:06Z","timestamp":1793176086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154752712602388X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S154752712602388X"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.05.021","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sudden cardiac death and major arrhythmic events in patients with Fabry disease: Risk stratification in the French Heart Fabry cohort multicenter study","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}